Výsledky vyhledávání - "Erzsébet Ravasz, Regan"

Akademický článek

Unlocking mitochondrial dysfunction-associated senescence (MiDAS) with NAD+ – A Boolean model of mitochondrial dynamics and cell cycle control

Autor: Herbert Sizek, Dávid Deritei, Katherine Fleig, Marlayna Harris, Peter L. Regan, Kimberly Glass, Erzsébet Ravasz Regan

Publikováno v: Translational Oncology, Vol 49, Iss , Pp 102084- (2024)

The steady accumulation of senescent cells with aging creates tissue environments that aid cancer evolution. Aging cell states are highly heterogeneous. 'Deep senescent' cells rely on healthy mitochondria to fuel a strong proinflammatory secretome, i

Externí odkaz: https://doaj.org/article/d3964a122568414884e9a7d26148d4d4

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Akademický článek

Boolean modeling of mechanosensitive epithelial to mesenchymal transition and its reversal

Autor: Emmalee Sullivan, Marlayna Harris, Arnav Bhatnagar, Eric Guberman, Ian Zonfa, Erzsébet Ravasz Regan

Publikováno v: iScience, Vol 26, Iss 4, Pp 106321- (2023)

Summary: The significance of biophysical modulators of the epithelial to mesenchymal transition (EMT) is demonstrated by experiments that document full EMT on stiff, nano-patterned substrates in the absence of biochemical induction. Yet, current mode

Externí odkaz: https://doaj.org/article/63cc82f46e0a47b089b76ea53f08e933

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Akademický článek

Boolean model of anchorage dependence and contact inhibition points to coordinated inhibition but semi-independent induction of proliferation and migration

Autor: Eric Guberman, Hikmet Sherief, Erzsébet Ravasz Regan

Publikováno v: Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2145-2165 (2020)

Epithelial cells respond to their physical neighborhood with mechano-sensitive behaviors required for development and tissue maintenance. These include anchorage dependence, matrix stiffness-dependent proliferation, contact inhibition of proliferatio

Externí odkaz: https://doaj.org/article/271adacf119e4803a1e8b7459774607e

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Akademický článek

Boolean model of growth signaling, cell cycle and apoptosis predicts the molecular mechanism of aberrant cell cycle progression driven by hyperactive PI3K.

Autor: Herbert Sizek, Andrew Hamel, Dávid Deritei, Sarah Campbell, Erzsébet Ravasz Regan

Publikováno v: PLoS Computational Biology, Vol 15, Iss 3, p e1006402 (2019)

The PI3K/AKT signaling pathway plays a role in most cellular functions linked to cancer progression, including cell growth, proliferation, cell survival, tissue invasion and angiogenesis. It is generally recognized that hyperactive PI3K/AKT1 are onco

Externí odkaz: https://doaj.org/article/0b3c5cbd0b444a19ad21cf698eef109d

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Akademický článek

A role of stochastic phenotype switching in generating mosaic endothelial cell heterogeneity

Autor: Lei Yuan, Gary C. Chan, David Beeler, Lauren Janes, Katherine C. Spokes, Harita Dharaneeswaran, Anahita Mojiri, William J. Adams, Tracey Sciuto, Guillermo Garcia-Cardeña, Grietje Molema, Peter M. Kang, Nadia Jahroudi, Philip A. Marsden, Ann Dvorak, Erzsébet Ravasz Regan, William C. Aird

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)

Spontaneous phenotypic heterogeneity confers a population-level advantage to cells that are exposed to fluctuating environments. Here the authors show that the endothelium of some organs displays a dynamic mosaicism in expression of Von Willebrand fa

Externí odkaz: https://doaj.org/article/6ed9333a2a8b469cb9f3182d7d55819d

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