Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Erzhen Zhen"'
Autor:
Erik Schaefer, Shih Khoo, Sarah Witt, Vuong Do, Alphonsus Dang, Melanie H. Cobb, Erzhen Zhen, Shuichan Xu
Publikováno v:
Molecular Endocrinology. 11:1618-1625
Mitogen-activated protein (MAP)/ERK kinase (MEK)1 and MEK2 are the upstream activators of the MAP kinases, ERK1 and ERK2. MEK1 and MEK2 are approximately 85% identical in sequence but have unique inserts in their C-terminal domains. MEK isoform-speci
Autor:
Douglas Ebert, Mangeng Cheng, Alphonsus Dang, Clark Garcia, David J. Robbins, Erzhen Zhen, Shuichan Xu, Colleen A. Vanderbilt, Melanie H. Cobb
Publikováno v:
Journal of the American Society of Nephrology. 4:1104-1110
The extracellular signal-regulated kinases ERK1 and ERK2 are 43- and 41-kd enzymes activated by many extracellular cues. They lie within a protein kinase cascade that is used to achieve many cellular responses. In addition to the wide variety of regu
Autor:
Hajime Owaki, Melanie H. Cobb, Douglas Ebert, Erzhen Zhen, Thomas D. Geppert, Colleen A. Vanderbilt, David J. Robbins
Publikováno v:
Journal of Biological Chemistry. 268:5097-5106
Extracellular signal-regulated protein kinases (ERK) 1 and 2 and mutants of each were expressed in bacteria with a hexahistidine tag and purified using nickel-chelate chromatography. Basal activity of wild type ERK2 was approximately 2 nmol/min/mg. S
Autor:
Colleen A. Vanderbilt, Erzhen Zhen, Mangeng Cheng, Melanie H. Cobb, David J. Robbins, Larry A. Feig
Publikováno v:
Proceedings of the National Academy of Sciences. 89:6924-6928
The small GTP-binding protein Ras appears to be required for transformation and differentiation induced by tyrosine kinases. The Ras requirement may be limited to a few tyrosine kinase-regulated signaling pathways or may be universal for all tyrosine
Autor:
George E. Kopchok, David Rosenbaum, Miguel Fragoso, York N. Hsiang, Carol Guthrie, Rodney A. White, Shi-Kaung Peng, John Kao, Erzhen Zhen
Publikováno v:
Journal of Surgical Research. 50:252-258
Long-term patency of vascular angioplasties is limited by stenosis from neointimal hyperplasia or progressive arteriosclerosis. This study evaluated the hypothesis that ASA (an antiprostaglandin) or Probucol (an antioxidant) may be useful in preventi
Autor:
Erzhen Zhen, Melanie H. Cobb, Doug Ebert, Megan Robinson, Mangeng Cheng, Elizabeth J. Goldsmith
Publikováno v:
The Journal of biological chemistry. 271(20)
A novel protein kinase activity present in nuclear and cytosolic extracts has been identified and partially purified as a consequence of its tight binding to and phosphorylation of the extracellular signal-regulated protein kinase (ERK) 3. This novel
Publikováno v:
Advances in Cancer Research ISBN: 9780120066636
Publisher Summary MAP kinase is used to refer to at least two distinct proteins, known as the extracellular signal-regulated protein kinases ERK 1 and ERK2. The discussion of proteins that are regulated by ERKs points to the pleiotropic nature of sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf2832a804d1ceaa1c36cba182df4537
https://doi.org/10.1016/s0065-230x(08)60399-1
https://doi.org/10.1016/s0065-230x(08)60399-1
Autor:
Clark Garcia, Douglas Ebert, Alphonsus Dang, Erzhen Zhen, David J. Robbins, Melanie H. Cobb, Colleen A. Vanderbilt, Mangeng Cheng
Publikováno v:
The Cell Cycle ISBN: 9781461360278
Extracellular signal-regulated kinases (ERKs)1–4 are protein kinases participating in numerous signal transduction pathways. The two best studied of these, ERK1 and ERK2, are known as MAP kinases and were first identified as 43 and 41 kDa, hormonal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d4bdf320e8aeeb00ccc0a15b48895a8
https://doi.org/10.1007/978-1-4615-2421-2_7
https://doi.org/10.1007/978-1-4615-2421-2_7
Publikováno v:
Free Radical Biology and Medicine. 7:243-249
An increased lipid peroxides and a decreased production of prostacyclin have been shown in advanced atherosclerotic lesions and plasma. Our purpose was to determine whether the similar findings could be observed in cultured endothelial cells, and whe
Publikováno v:
Experimental and Molecular Pathology. 48:153-160
Rabbits fed an atherogenic diet for 60 days resulted in high levels of plasma lipid peroxides as well as extreme hypercholesterolemia. Both levels stayed high until 35 days after the atherogenic diet stopped. At the same time, plasma PGI2 level was r