Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19

Autor: Jan Heyckendorf, Elisa Rosati, Jens Stoye, Andreas Dräger, Alex K. Shalek, Daniela Bezdan, Norbert Frey, Ulisses Nunes da Rocha, Thomas Bahmer, Simon Imm, Antoine-Emmanuel Saliba, Markus Landthaler, Ezio Bonifacio, Maria Colme-Tatche, Annika Schaffarzyk, Alexander Sczyrba, Dora Bordoni, David Ellinghaus, Christoph Lange, Stefan Janssen, Nicholas E. Banovich, Laure-Emmanuelle Zaragosi, Markus M. Nöthen, Anette Friedrichs, Alexander M. Tsankov, Teide Boysen, Andreas Glück, Philipp H. Schiffer, Lena Best, Oliver Eickelberg, Silke Peter, Nathan Baran, Maarten van den Berge, Oliver Kohlbacher, Anna R. Poetsch, Michael Hummel, Ulf Geisen, Dagmar Wieczorek, Alexander T. Dilthey, Burkhard Brandt, Kerstin B. Meyer, Christian Mertes, Jonas Schulte-Schrepping, Florian Tran, Birgit Sawitzki, Hauke Busch, Christoph Klein, Christos Samakovlis, Niklaus Rajewsky, Joachim Schultze, Sören Franzenburg, Jörn Walter, Sina Kaiser, Jörg Vogel, Niklas Bruse, Marc P. Hoeppner, Muzlifa Haniffa, Alina Renz, Purushothama Rao Tata, Stephan Ripke, Ralf Junker, Michael von Papen, Jonathan A. Kropski, Max von Kleist, Oliver Stegle, Neha Mishra, Jörg Overmann, Johanna I. Blase, Nicole Fischer, Jeffrey A. Whitsett, Sarah A. Teichmann, Birte Kehr, Domagoj Schunk, Julia Fischer, Andreas Diefenbach, Joakim Lundeberg, Matthijs Kox, Klaus-Peter Wandinger, Michael Forster, Ingo Kurth, Johannes Zimmermann, Yang Li, René Kallies, Petra Bacher, Torsten Hain, Joachim L. Schultze, Clemens Lier, Klaus Pfeffer, Michael Wittig, Jacob Nattermann, Paul A. Reyfman, Peter Nürnberg, Alfred Pühler, Andre Franke, Markus Ralser, Peter Pickkers, Andreas Keller, Matthias Lindner, Philipp Köhler, Dana Pe'er, Gunnar Elke, Jan Rybniker, Jonathan Josephs-Spaulding, Alexander Goesmann, Anke Becker, Aviv Regev, Ying H. Kan, Alexander Bartholomäus, Rainer Noth, Jonathan Dörr, Julia-Stefanie Frick, Stephan Ossowski, Bimba F. Hoyer, Peter Horvath, Jose Ordovas Montanes, Dirk Skowasch, Philip Rosenstiel, Georg Laue, Oliwia Makarewicz, Stefan Schreiber, Alexander Scheffold, Christoph Röcken, Leif E. Sander, Manja Marz, Joana P. Bernardes, Jörn Kalinowski, Uwe Ohler, Robert Markewitz, Jason R. Spence, Robert Lafyatis, Thomas Ulas, Peer Bork, Tushar J. Desai, Janne Vehreschild, Janina Fuß, Olaf Rieß, Robert Bals, Klaus F. Rabe, Jacob Hamm, Martijn C. Nawijn, John Ziebuhr, Angel Angelov, Fabian J. Theis, Rainer Knoll, Jan O. Korbel, Thomas Clavel, Konrad U. Förstner, Jan Rupp, Sarah Kim-Hellmuth, Christoph Kaleta, Alice C. McHardy, Anna C. Aschenbrenner, Emma L. Rawlins, Douglas P. Shepherd, Julien Gagneur, Marko Nikolic, Georgios Marinos, Jeanette Franzenburg, Eva-Christina Schulte, Axel Künstner, Andreas Walker, Finn Hinrichsen, Kerstin U. Ludwig

Publikováno v: Immunity, 53, 1296-1314.e9
Immunity, 53(6), 1296-1314.e9. CELL PRESS
Immunity 53(6), 1296-1314.e9 (2020). doi:10.1016/j.immuni.2020.11.017
Immunity
Immunity, 53, 6, pp. 1296-1314.e9
1314.e9
United States

Temporal resolution of cellular features associated with a severe COVID-19 disease trajectory is required for understanding skewed immune responses and finding outcome predictors. Here, we performed a longitudinal multi-omics study using a two-centre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b9ae7fbbaa61a6ed5bec38333230f7e
https://doi.org/10.1016/j.immuni.2020.11.017