Effect of Mercury on Membrane Proteins, Anionic Transport and Cell Morphology in Human Erythrocytes

Autor: Notariale, Rosaria, Längst, Emmanuel, Perrone, Pasquale, Crettaz, David, Prudent, Michel, Manna, Caterina

Publikováno v: Cellular physiology and biochemistry, vol. 56, no. 5, pp. 500-513

Mercury (Hg) is a heavy metal widespread in all environmental compartments as one of the most hazardous pollutants. Human exposure to this natural element is detrimental for several cellular types including erythrocytes (RBC) that accumulate Hg mainl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c800def978abb829333b24357425570f
https://doi.org/10.33594/000000572

Endothelial struts enable the generation of large lumenized blood vessels de novo

Autor: David Traver, Catherine Robin, Mark H. Ginsberg, David Kleinfeld, Iftach Shaked, Bart Weijts

Publikováno v: Nature cell biology, vol 23, iss 4
Nature cell biology
Nature Cell Biology, 23(4), 322-329. Nature Publishing Group

De novo blood vessel formation occurs through coalescence of endothelial cells (ECs) into a cord-like structure, followed by lumenization either through cell-1-3 or cord-hollowing4-7. Vessels generated in this manner are restricted in diameter to one

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dffc60bf24446e1510f77fc5aca67b13
https://escholarship.org/uc/item/49d9x5fj

Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates

Autor: Jiri Gut, Nuno Vale, Fátima Nogueira, Luísa Aguiar, Philip J. Rosenthal, Paula Gomes, Xavier Fernàndez-Busquets, David Andreu, Elena Lantero, Arnau Biosca

Publikováno v: Molecules
Volume 24
Issue 24
Recercat. Dipósit de la Recerca de Catalunya
instname

Recently, we disclosed primaquine cell penetrating peptide conjugates that were more potent than parent primaquine against liver stage Plasmodium parasites and non-toxic to hepatocytes. The same strategy was now applied to the blood-stage antimalaria

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae9e043ec8e6faa1d496331b652f11c
https://pubmed.ncbi.nlm.nih.gov/31842498

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium

Autor: Jerome I. Rotter, Abbas Dehghan, Gang Zheng, Willem H. Ouwehand, Caroline S. Fox, Jack M. Guralnik, Tamara B. Harris, Toshiko Tanaka, Andrew E. Jaffe, Albert Hofman, Andrew B. Singleton, Jing-Ping Lin, Joshua C. Bis, Santhi K. Ganesh, Christian Gieger, Christa Meisinger, Jaap Jan Zwaginga, Mary Cushman, Matthias Nauck, Aravinda Chakravarti, Gudny Eiriksdottir, Daniel Levy, Kenneth Rice, Swee Lay Thein, Augusto Rendon, Vilmundur Gudnason, Luigi Ferrucci, Frank J. A. van Rooij, Jennifer G. Sambrook, Andreas Greinacher, Dena G. Hernandez, Jacqueline C.M. Witteman, Lenore J. Launer, Qiong Yang, Thor Aspelund, Panos Deloukas, Eric Boerwinkle, Ben A. Oostra, Germaine C. Verwoert, Cornelia M. van Duijn, Albert V. Smith, Thomas Lumley, Anna Köttgen, Nicole L. Glazer, André G. Uitterlinden, Janine M. Vangils, Ming-Huei Chen, Georg Ehret, Janine F. Felix, Mike A. Nalls, Kushang V. Patel, Alexander Teumer, L. Adrienne Cupples, Susan L. Furth, Christopher J. O'Donnell, Josef Coresh, Tim D. Spector, Brigitte Kühnel, Stefania Bandinelli, Neil A. Zakai, Nicole Soranzo, Bruce M. Psaty

Publikováno v: Nature genetics
Nature Genetics, Vol. 41, No 11 (2009) pp. 1191-1198
Nature Genetics, 41(11), 1191-U48. Nature Publishing Group

Measurements of erythrocytes within the blood are important clinical traits and can indicate various hematological disorders. We report here genome-wide association studies (GWAS) for six erythrocyte traits, including hemoglobin concentration (Hb), h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c19e41e06d50b5bfeecad06fdaab1be
https://doi.org/10.1038/ng.466

The clinical significance of K-Cl cotransport activity in red cells of patients with HbSC disease

Autor: A Osei, Swee Lay Thein, Emma Drasar, Anke Hannemann, David C. Rees, John S. Gibson, Sanjay Tewari

Publikováno v: Rees, D C, Thein, S L, Osei, A, Drasar, E, Tewari, S, Hannemann, A & Gibson, J S 2015, ' The clinical significance of K-Cl cotransport activity in red cells of patients with HbSC disease ', Haematologica, vol. 100, no. 5, pp. 595-600 . https://doi.org/10.3324/haematol.2014.120402

HbSC disease is the second commonest form of sickle cell disease, with poorly understood pathophysiology and few treatments. We studied the role of K-Cl cotransport activity in determining clinical and laboratory features, and investigated its potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783794b60fd3243dd229ba22ebbb764e
https://www.repository.cam.ac.uk/handle/1810/254438