Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Eryn L. Werry"'
Autor:
Michael A. Sullivan, Samuel D. Lane, André D. J. McKenzie, Sarah R. Ball, Margaret Sunde, G. Gregory Neely, Cesar L. Moreno, Alexandra Maximova, Eryn L. Werry, Michael Kassiou
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-23 (2024)
Abstract Background Widescale evidence points to the involvement of glia and immune pathways in the progression of Alzheimer’s disease (AD). AD-associated iPSC-derived glial cells show a diverse range of AD-related phenotypic states encompassing cy
Externí odkaz:
https://doaj.org/article/ef7a844245764d02918279afb7d9cfa9
Autor:
Hei W. A. Cheng, Timothy B. Callis, Andrew P. Montgomery, Jonathan J. Danon, William T. Jorgensen, Yazi D. Ke, Lars M. Ittner, Eryn L. Werry, Michael Kassiou
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14769 (2022)
The use of cellular models is a common means to investigate the potency of therapeutics in pre-clinical drug discovery. However, there is currently no consensus on which model most accurately replicates key aspects of amyotrophic lateral sclerosis (A
Externí odkaz:
https://doaj.org/article/0cd45e13fb134f9ea0fc69ac7f8afbe1
Autor:
Sarah R. Ball, Julius S. P. Adamson, Michael A. Sullivan, Manuela R. Zimmermann, Victor Lo, Maximo Sanz-Hernandez, Xiaofan Jiang, Ann H. Kwan, André D. J. McKenzie, Eryn L. Werry, Tuomas P. J. Knowles, Michael Kassiou, Georg Meisl, Matthew H. Todd, Peter J. Rutledge, Margaret Sunde
Publikováno v:
ACS Chemical Neuroscience. 14:87-98
Alzheimer's disease is imposing a growing social and economic burden worldwide, and effective therapies are urgently required. One possible approach to modulation of the disease outcome is to use small molecules to limit the conversion of monomeric a
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 12078 (2021)
Amyotrophic lateral sclerosis (ALS) is a progressive motor neurodegenerative disease that currently has no cure and has few effective treatments. On a cellular level, ALS manifests through significant changes in the proper function of astrocytes, mic
Externí odkaz:
https://doaj.org/article/337823380b344cbeb83fcaaed13ab187
Publikováno v:
ACS Chemical Neuroscience. 13:1479-1490
Autor:
Michael A. Sullivan, Samuel D. Lane, Sarah R. Ball, Margaret Sunde, G. Gregory. Neely, Cesar Moreno, Eryn L. Werry, Michael Kassiou
BackgroundWidescale evidence points to the involvement of glia and immune pathways in the progression of Alzheimer’s disease (AD). AD-associated iPSC-derived glial cells show a diverse range of AD-related phenotypic states encompassing cytokine/che
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cac8d346a05ce552b0377634d4a30b0f
https://doi.org/10.1101/2022.12.05.518134
https://doi.org/10.1101/2022.12.05.518134
Autor:
Michael A. Sullivan, Samuel D. Lane, Alexander Volkerling, Martin Engel, Eryn L. Werry, Michael Kassiou
Current research tools for pre-clinical drug development such as rodent models and 2D immortalised monocultures have failed to serve as effective translational models for human CNS disorders. Recent advancements in the development of iPSCs and 3D cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c557ec5f4c2cc5f06820aa2a81bc4385
https://doi.org/10.22541/au.166852614.45511209/v1
https://doi.org/10.22541/au.166852614.45511209/v1
Publikováno v:
ACS chemical neuroscience. 13(10)
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by upper and lower motor neuron loss. The pathomechanisms of ALS are still poorly understood with current hypotheses involving genetic mutations, excitotoxic
Autor:
Eryn L. Werry, Fiona M. Bright, Olivier Piguet, Lars M. Ittner, Glenda M. Halliday, John R. Hodges, Matthew C. Kiernan, Clement T. Loy, Jillian J. Kril, Michael Kassiou
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3161 (2019)
Neuroinflammation is an inflammatory response in the brain and spinal cord, which can involve the activation of microglia and astrocytes. It is a common feature of many central nervous system disorders, including a range of neurodegenerative disorder
Externí odkaz:
https://doaj.org/article/e6925446d00444c6bd1ab3681a0404bf
Publikováno v:
Neurodegenerative Diseases Biomarkers ISBN: 9781071617113
Neurodegenerative Diseases Biomarkers
Neurodegenerative Diseases Biomarkers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::005d1dd9172052924ce7ae8763df5e77
https://doi.org/10.1007/978-1-0716-1712-0_17
https://doi.org/10.1007/978-1-0716-1712-0_17