Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Eryn E. Dixon"'
Autor:
Haojia Wu, Eryn E. Dixon, Qiao Xuanyuan, Juanru Guo, Yasuhiro Yoshimura, Chitnis Debashish, Anezka Niesnerova, Hao Xu, Morgane Rouault, Benjamin D. Humphreys
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Emerging spatially resolved transcriptomics technologies allow for the measurement of gene expression in situ at cellular resolution. We apply direct RNA hybridization-based in situ sequencing (dRNA HybISS, Cartana part of 10xGenomics) to co
Externí odkaz:
https://doaj.org/article/227cd3e034c34e63baed1ad49c0fbc42
Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease
Autor:
Parker C. Wilson, Amit Verma, Yasuhiro Yoshimura, Yoshiharu Muto, Haikuo Li, Nicole P. Malvin, Eryn E. Dixon, Benjamin D. Humphreys
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-27 (2024)
Abstract Background Mosaic loss of Y chromosome (LOY) is the most common chromosomal alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that LOY is present in the kidney and increases with age and chronic kidney disease
Externí odkaz:
https://doaj.org/article/551e6c9819dd473baf7dff771a4e8c17
Autor:
Yoshiharu Muto, Eryn E. Dixon, Yasuhiro Yoshimura, Haojia Wu, Kohei Omachi, Nicolas Ledru, Parker C. Wilson, Andrew J. King, N. Eric Olson, Marvin G. Gunawan, Jay J. Kuo, Jennifer H. Cox, Jeffrey H. Miner, Stephen L. Seliger, Owen M. Woodward, Paul A. Welling, Terry J. Watnick, Benjamin D. Humphreys
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Autosomal dominant polycystic kidney disease (ADPKD) is a complicated disease that involves numerous cell types. Here the authors used a multiomics approach consisting of single nucleus transcriptomes and epigenomes to redefine cell states in ADPKD a
Externí odkaz:
https://doaj.org/article/7703e88d9d3a4383b2b0dd9ea8ab76ec
Autor:
Mohammad Ikbal Choudhury, Yizeng Li, Panagiotis Mistriotis, Ana Carina N. Vasconcelos, Eryn E. Dixon, Jing Yang, Morgan Benson, Debonil Maity, Rebecca Walker, Leigha Martin, Fatima Koroma, Feng Qian, Konstantinos Konstantopoulos, Owen M. Woodward, Sean X. Sun
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
How mechanical forces drive fluid transport in the kidney remains unclear. Here, the authors use a microfluidic platform to show that kidney epithelial cells generate hydraulic pressure gradients across the epithelium, and that the fluid flux is from
Externí odkaz:
https://doaj.org/article/b58fd862a1154805bc1deba371303c2a
Autor:
Kazi Mirajul Hoque, Eryn E. Dixon, Raychel M. Lewis, Jordyn Allan, Gregory D. Gamble, Amanda J. Phipps-Green, Victoria L. Halperin Kuhns, Anne M. Horne, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth, Owen M. Woodward
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant r
Externí odkaz:
https://doaj.org/article/12c73f6333324432b9f2c84850631506
Publikováno v:
Kidney international. 102(3)
Defining changes in gene expression during health and disease is critical for the understanding of human physiology. In recent years, single-cell/nuclei RNA sequencing (sc/snRNAseq) has revolutionized the definition and discovery of cell types and st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8313f58221d4a4c1cfa9a5ab466a346c
https://pubmed.ncbi.nlm.nih.gov/35788360
https://pubmed.ncbi.nlm.nih.gov/35788360
Autor:
Tony R. Merriman, Raychel M. Lewis, Owen M. Woodward, Gregory D. Gamble, Anne Horne, Lisa K. Stamp, Eryn E. Dixon, Nicola Dalbeth, Amanda Phipps-Green, Kazi Mirajul Hoque, Jordyn Allan, Victoria L. Halperin Kuhns
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The pathophysiological nature of the common ABCG2 gout and hyperuricemia associated variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8319ecab2e474627adea2cb89008a685
https://doaj.org/article/12c73f6333324432b9f2c84850631506
https://doaj.org/article/12c73f6333324432b9f2c84850631506
Publikováno v:
J Am Soc Nephrol
Background Single cell sequencing technologies have advanced our understanding of kidney biology and disease but the loss of spatial information in these datasets hinders our interpretation of intercellular communication networks and regional gene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2e21933c2249f73a68738976d472a90
https://europepmc.org/articles/PMC8819997/
https://europepmc.org/articles/PMC8819997/
Publikováno v:
Cell Metabolism. 34:1977-1998.e9
The underlying cellular events driving kidney fibrogenesis and metabolic dysfunction are incompletely understood. Here, we employed single-cell combinatorial indexing RNA sequencing to analyze 24 mouse kidneys from two fibrosis models. We profiled 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b5bcdc1e3e6815453f70f4cc2c78bb
https://doi.org/10.1016/j.cmet.2022.09.026
https://doi.org/10.1016/j.cmet.2022.09.026
Publikováno v:
Cell Stem Cell. 29:1011-1012
In this issue of Cell Stem Cell, Tran and colleagues develop a platform for differentiating thousands of miniature kidney organoids consisting of one or two nephron-like structures each. They use this platform to identify a potent new inhibitor of cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f72c7f7d41d246b3b590c646850a2606
https://doi.org/10.1016/j.stem.2022.06.009
https://doi.org/10.1016/j.stem.2022.06.009