Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Erya Yu"'
Publikováno v:
Xenobiotica. 49:302-312
1. Aldehyde oxidase (AO enzymes)-mediated oxidation predominantly occurs at a carbon atom adjacent to the nitrogen on aromatic azaheterocycles. In the current report, we identified that AO enzymes oxidation took place at both the C-2 and C-4 position
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfee8a765c52e8b265fd5cdad40ae2d
https://doi.org/10.1080/00498254.2018.1444815
https://doi.org/10.1080/00498254.2018.1444815
Publikováno v:
Rapid Communications in Mass Spectrometry. 28:123-134
Rationale Recent publications have reported that imatinib forms cyanide and methoxylamine adducts in vitro but without detail structural identification. The current work reports the identification of seven cyanide adducts that elucidate the bioactiva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd88fb5662fc5ee1a4897d38a0807cb1
https://doi.org/10.1002/rcm.6758
https://doi.org/10.1002/rcm.6758
Publikováno v:
Chemical Research in Toxicology. 26:608-615
Medicinal chemists try to avoid certain organic functional groups, summarized in an ever-growing list, in order to avoid the potential bioactivation to reactive metabolites. To add to that alert list, we report herein that boronic acid-containing com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf2dbd55c242135d9eeb544334eb82f
https://doi.org/10.1021/tx400032n
https://doi.org/10.1021/tx400032n
Publikováno v:
Rapid Communications in Mass Spectrometry. 26:906-914
RATIONALE Drug metabolites that have imine or enamine partial structures cause extra mass-to-charge (m/z) increases in online hydrogen/deuterium exchange (HDX) in addition to hydroxyl or amine protons. Online HDX and exact mass measurement were used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af8152053188cfbc891a7ca6d49a77b3
https://doi.org/10.1002/rcm.6178
https://doi.org/10.1002/rcm.6178
Publikováno v:
Rapid communications in mass spectrometry : RCM. 28(1)
Recent publications have reported that imatinib forms cyanide and methoxylamine adducts in vitro but without detail structural identification. The current work reports the identification of seven cyanide adducts that elucidate the bioactivation pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e7849e0cad7122f56c0b8ebd7735c688
https://pubmed.ncbi.nlm.nih.gov/24285397
https://pubmed.ncbi.nlm.nih.gov/24285397
Autor:
Nicola Neff, Peter E. Grebow, Frank Baldino, Kathleen V. Callison, Jeffry L. Vaught, Michael E. Lewis, Patricia C. Contreras, Erya Yu
Publikováno v:
Annals of the New York Academy of Sciences. 692:201-208
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd274f688a5c960598b2c5982da2876a
https://doi.org/10.1111/j.1749-6632.1993.tb26218.x
https://doi.org/10.1111/j.1749-6632.1993.tb26218.x
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 35(10)
Bendamustine, a bifunctional alkylating agent, is currently in clinical trials for the treatment of hematological and other malignancies. Although it has been used in the former East Germany for more than 30 years, very limited information is availab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0718fc641d93d775d6f5d7bed89e8256
https://pubmed.ncbi.nlm.nih.gov/17600082
https://pubmed.ncbi.nlm.nih.gov/17600082
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 37(5)
The objective of the current study was to investigate the metabolism of cytochrome P450 (CYP) probe substrates in male Sprague Dawley rat liver microsomes and to determine their substrate specificities. Time and microsomal protein concentrations were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f56782b0ccced347200d5be77b7abb7
https://pubmed.ncbi.nlm.nih.gov/17523050
https://pubmed.ncbi.nlm.nih.gov/17523050
Publikováno v:
Chemical Research in Toxicology; Apr2013, Vol. 26 Issue 4, p608-615, 8p
Autor:
Li, Austin C.1 austin.li@tevapharm.com, Cui, Donghui1, Yu, Erya1, Dobson, Kyle1, Hellriegel, Edward T.1, Robertson Jr, Philmore1
Publikováno v:
Xenobiotica. Mar2019, Vol. 49 Issue 3, p302-312. 11p.