Zobrazeno 1 - 10
of 752
pro vyhledávání: '"Erwin W. Gelfand"'
Autor:
Geza Ambrus-Aikelin, Katsuyuki Takeda, Anthony Joetham, Milos Lazic, Davide Povero, Angelina M. Santini, Rama Pranadinata, Casey D. Johnson, Matthew D. McGeough, Federico C. Beasley, Ryan Stansfield, Christopher McBride, Lynnie Trzoss, Hal M. Hoffman, Ariel E. Feldstein, Jeffrey A. Stafford, James M. Veal, Gretchen Bain, Erwin W. Gelfand
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract The NLRP3 inflammasome is an intracellular, multiprotein complex that promotes the auto-catalytic activation of caspase-1 and the subsequent maturation and secretion of the pro-inflammatory cytokines, IL-1β and IL-18. Persistent activation
Externí odkaz:
https://doaj.org/article/a9366cea20b64379ae3b798f5d428a2d
Autor:
Geza Ambrus-Aikelin, Katsuyuki Takeda, Anthony Joetham, Milos Lazic, Davide Povero, Angelina M. Santini, Rama Pranadinata, Casey D. Johnson, Matthew D. McGeough, Federico C. Beasley, Ryan Stansfield, Christopher McBride, Lynnie Trzoss, Hal M. Hoffman, Ariel E. Feldstein, Jeffrey A. Stafford, James M. Veal, Gretchen Bain, Erwin W. Gelfand
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/71601d03ca0a42d8941718d51407d3e9
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-11 (2021)
Abstract Background Alpha-1 antitrypsin (AAT) is a major serine protease inhibitor. AAT deficiency (AATD) is a genetic disorder characterized by early-onset severe emphysema. In well-selected AATD patients, therapy with plasma-derived AAT (pAAT), “
Externí odkaz:
https://doaj.org/article/9ee8255ff0a541978be194128084f1c0
CFTR-mediated monocyte/macrophage dysfunction revealed by cystic fibrosis proband-parent comparisons
Autor:
Xi Zhang, Camille M. Moore, Laura D. Harmacek, Joanne Domenico, Vittobai Rashika Rangaraj, Justin E. Ideozu, Jennifer R. Knapp, Katherine J. Woods, Stephanie Jump, Shuang Jia, Jeremy W. Prokop, Russell Bowler, Martin J. Hessner, Erwin W. Gelfand, Hara Levy
Publikováno v:
JCI Insight, Vol 7, Iss 6 (2022)
Cystic fibrosis (CF) is an inherited disorder caused by biallelic mutations of the CF transmembrane conductance regulator (CFTR) gene. Converging evidence suggests that CF carriers with only 1 defective CFTR copy are at increased risk for CF-related
Externí odkaz:
https://doaj.org/article/a63d56dde4aa4e118ea14046497fc7b7
Autor:
Nathan Rabinovitch, Meaghan J. Jones, Nicole Gladish, Anna V. Faino, Matthew Strand, Alexander M. Morin, Julie MacIsaac, David T. S. Lin, Paul R. Reynolds, Amrit Singh, Erwin W. Gelfand, Michael S. Kobor, Christopher Carlsten
Publikováno v:
Epigenetics, Vol 16, Iss 2, Pp 177-185 (2021)
Air pollution is associated with early declines in lung function and increased levels of asthma-related cysteinyl leukotrienes (CysLT) but a biological pathway linking this rapid response has not been delineated. In this randomized controlled diesel
Externí odkaz:
https://doaj.org/article/de69246eb7144191a962e43961d0a1b0
Autor:
Jordan K. Abbott, Sanny K. Chan, Morgan MacBeth, James L. Crooks, Cathy Hancock, Vijaya Knight, Erwin W. Gelfand
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Despite adequate infection prophylaxis, variation in self-reported quality of life (QOL) throughout the intravenous immunoglobulin (IVIG) infusion cycle is a widely reported but infrequently studied phenomenon. To better understand this phenomenon, s
Externí odkaz:
https://doaj.org/article/53fb5284bc5e460eae3f8ac642019b0e
Publikováno v:
European Respiratory Review, Vol 28, Iss 154 (2019)
The complexity of asthma is underscored by the number of cell types and mediators implicated in the pathogenesis of this heterogeneous syndrome. Type 2 CD4+ T-cells (Th2) and more recently, type 2 innate lymphoid cells dominate current descriptions o
Externí odkaz:
https://doaj.org/article/2f0a377e9c96415c9778d3b54907d6ad
Autor:
Anna K. Meyer, Mindy Banks, Tibor Nadasdy, Jennifer J. Clark, Rui Zheng, Erwin W. Gelfand, Jordan K. Abbott
Publikováno v:
Frontiers in Pediatrics, Vol 7 (2019)
A subset of patients with Ataxia-Telangiectasia (A-T) have dramatically reduced levels of IgG, IgA, and IgE with retained or elevated IgM levels. Several reports suggest that these A-T patients with a “hyper-IgM phenotype” (HIgM) suffer more clin
Externí odkaz:
https://doaj.org/article/0c90d378b24c4ed6b75b7b79b325d3a3
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4582 (2021)
The impact of naturally occurring regulatory T cells (nTregs) on the suppression or induction of lung allergic responses in mice depends on the nuclear environment and the production of the pro-inflammatory cytokine interleukin 6 (IL-6). These activi
Externí odkaz:
https://doaj.org/article/4010725e41894eff8b92c3912d2fc1ec
Autor:
Michaela Schedel, Yi Jia, Sven Michel, Katsuyuki Takeda, Joanne Domenico, Anthony Joetham, Fangkun Ning, Matthew Strand, Junyan Han, Meiqin Wang, Joseph J. Lucas, Christian Vogelberg, Michael Kabesch, Brian P. O’Connor, Erwin W. Gelfand
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Type 2 CD8+ T cells (Tc2) play a role in the development of experimental asthma. Here the authors show that 1,25D3, the active form of vitamin D3, can prevent conversion of CD8+T cells to a Tc2 phenotype, reducing asthma susceptibility.
Externí odkaz:
https://doaj.org/article/4a78e690244b43d29f1c6343ad4eae22