Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Erwin M. Lee"'
Autor:
Erwin M. Lee, Dean Yee, Samantha J. Busfield, Julie F. McManus, Nik Cummings, Gino Vairo, Andrew Wei, Hayley S. Ramshaw, Jason A. Powell, Angel F. Lopez, Ian D. Lewis, Martin N. McCall, Richard B. Lock
Publikováno v:
Haematologica, Vol 100, Iss 7 (2015)
The prognosis of older patients with acute myelogenous leukemia is generally poor. The interleukin-3 receptor α-chain (CD123) is highly expressed on the surface of acute leukemia cells compared with normal hematopoietic stem cells. CSL362 is a fully
Externí odkaz:
https://doaj.org/article/b1c2cef3feeb436fbaf6e7b1a691d005
Autor:
Ricky W. Johnstone, Jake Shortt, Johannes Zuber, Richard B. Lock, Erwin M. Lee, Eva Vidacs, Joshua J. Hilton, Lev Kats, Inge Verbrugge, Gareth P. Gregory, Adele Baker
Translocations of the mixed lineage leukemia (MLL) gene occur in 60% to 80% of all infant acute leukemias and are markers of poor prognosis. MLL-AF9 and other MLL fusion proteins aberrantly recruit epigenetic regulatory proteins, including histone de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dc85c5f4249b88c1f1e6c3a72fe8d6b
https://doi.org/10.1158/0008-5472.c.6507881.v1
https://doi.org/10.1158/0008-5472.c.6507881.v1
Autor:
Joshua J. Hilton, Erwin M. Lee, Ricky W. Johnstone, Adele Baker, Eva Vidacs, Lev Kats, Johannes Zuber, Gareth P. Gregory, Inge Verbrugge, Richard B. Lock, Jake Shortt
Publikováno v:
Cancer Research. 76:1158-1169
Translocations of the mixed lineage leukemia (MLL) gene occur in 60% to 80% of all infant acute leukemias and are markers of poor prognosis. MLL-AF9 and other MLL fusion proteins aberrantly recruit epigenetic regulatory proteins, including histone de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd91e6d520790e382155c2166641e06
https://doi.org/10.1158/0008-5472.can-15-1070
https://doi.org/10.1158/0008-5472.can-15-1070
Autor:
Geoffrey R. Hill, Steven W. Lane, Richard B. Lock, Catherine Paine Kuhn, David A. Williams, Therese Vu, Erwin M. Lee, Frederik Otzen Bagger, Andrew S. Moore, Lars Bullinger, Scott A. Armstrong, Florian H. Heidel, Solene Guignes, Axia Song, Sarbjit Riyat, Claudia Bruedigam, Rebecca Austin
Publikováno v:
Cell Stem Cell. 15(6):775-790
SummaryAcute myeloid leukemia (AML) is an aggressive and lethal blood cancer maintained by rare populations of leukemia stem cells (LSCs). Selective targeting of LSCs is a promising approach for treating AML and preventing relapse following chemother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3fcef1c6d9627a8ee6ab75656f95a60
Autor:
Erwin M. Lee, Samantha J. Busfield, Andrew D. Nash, Con Panousis, M Wong, Angel F. Lopez, Daniel Thomas, Andrew W. Roberts, S Z He, Mark Biondo, Louis Fabri, Souravi Ghosh, Gino Vairo, Hal Braley, Richard B. Lock, Hayley S. Ramshaw
Publikováno v:
Leukemia. 28:2213-2221
Acute myeloid leukemia (AML) is a biologically heterogeneous group of related diseases in urgent need of better therapeutic options. Despite this heterogeneity, overexpression of the interleukin (IL)-3 receptor α-chain (IL-3 Rα/CD123) on both the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbec0ffba957f145a522e390f386ff18
https://doi.org/10.1038/leu.2014.128
https://doi.org/10.1038/leu.2014.128
Autor:
Hayley Flanagan, Anthony S. Don, Nicole M. Verrills, Leonie K. Ashman, Celeste L. Harrison, Kathryn A. Skelding, Daniel Thomas, Andrew S. Moore, Jason A. Powell, Richard G. S. Kahl, Anoop K Enjeti, Erwin M. Lee, Jonathan C. Morris, Richard B. Lock, Nikita Panicker, Matthew D. Dun, Mark A. Guthridge, Hamish D. Toop, Amanda Smith, Baratali Mashkani
Publikováno v:
Oncotarget
Constitutive activation of the receptor tyrosine kinase Fms-like tyrosine kinase 3 (FLT3), via co-expression of its ligand or by genetic mutation, is common in acute myeloid leukemia (AML). In this study we show that FLT3 activation inhibits the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2bd3d79869c60a8923914f2a71ec98c
https://pubmed.ncbi.nlm.nih.gov/27329844
https://pubmed.ncbi.nlm.nih.gov/27329844
Autor:
Richard B. Lock, Erwin M. Lee
Publikováno v:
Future Oncology. 5:1327-1330
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa8def140f44c8d6a91994ae33c0738
https://doi.org/10.2217/fon.09.115
https://doi.org/10.2217/fon.09.115
Autor:
Dean Yee, Hayley S. Ramshaw, Erwin M. Lee, Richard B. Lock, Jason A. Powell, Andrew H. Wei, Nicholas James Cummings, Ian D. Lewis, Julie McManus, Martin N. McCall, Angel F. Lopez, Samantha J. Busfield, Gino Vairo
The prognosis of older patients with acute myelogenous leukemia is generally poor. The interleukin-3 receptor alpha-chain (CD123) is highly expressed on the surface of acute leukemia cells compared with normal hematopoietic stem cells. CSL362 is a fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56173a4e724bccf666f776b2e2fc1e9a
https://hdl.handle.net/11541.2/127184
https://hdl.handle.net/11541.2/127184
Autor:
Duncan H Blair, Max R. Bennett, Christopher Holding, P. Poronnik, Erwin M. Lee, Guo-Hua Li, Julian A. Barden, David I. Cook
Publikováno v:
Journal of Biological Chemistry. 275:29107-29112
The distribution of P2X receptors on neurons in rat superior cervical ganglia and lability of P2X receptors on exposure to agonists were determined. Antibody labeling of each P2X subtype P2X(1)-P2X(7) showed neurons isolated into culture possessed pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d5be543ac45be38118b2cc981bec6f
https://doi.org/10.1074/jbc.m910277199
https://doi.org/10.1074/jbc.m910277199
Autor:
Stefan P Glaser, Richard B. Lock, Emma F Barry, Stéphane Manenti, Andrew H. Wei, David C.S. Huang, Benjamin D Green, Mark A. Guthridge, François Vergez, Jean-Emmanuel Sarry, Angel F. Lopez, Tracy L. Nero, Erwin M. Lee, Giovanna Pomilio, Paul G Ekert, Nhu-Y N Nguyen, Adele Baker, Anissa Jabbour, Christian Recher, Tse-Chieh Teh, Michael W. Parker, Susan K. Nilsson, Daniel Thomas, Jason A. Powell, David J. Segal
Publikováno v:
Blood. 122(5)
Resistance to cell death is a hallmark of cancer and renders transformed cells resistant to multiple apoptotic triggers. The Bcl-2 family member, Mcl-1, is a key driver of cell survival in diverse cancers, including acute myeloid leukemia (AML). A sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e40e8b022949c5cd28c37f1f6059be5
https://pubmed.ncbi.nlm.nih.gov/23775716
https://pubmed.ncbi.nlm.nih.gov/23775716