Výsledky vyhledávání - "Erwin Hans Duitman"

High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner

Autor: Christina Vock, Diego A. Goyeneche-Patino, Mylene Divivier, Julia K Polansky, Erwin Hans Duitman, Silvia Bulfone-Paus, Zane Orinska, Rajia Bahri

Publikováno v: Polansky, J K, Bahri, R, Divivier, M, Duitman, E H, Vock, C, Goyeneche-Patino, D A, Orinska, Z & Bulfone-Paus, S 2016, ' High dose CD11c-driven IL15 is sufficient to drive NK cell maturation and anti-tumor activity in a trans-presentation independent manner ', Scientific Reports, vol. 6, pp. 19699 . https://doi.org/10.1038/srep19699
Scientific Reports

The common gamma (γc)-chain cytokine interleukin 15 (IL15) is a multifunctional immune-modulator which impacts the generation, maturation and activity of many cell types of the innate, as well as the adaptive immune system, including natural killer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07f5f3a1b942961d7e21443e9eadf3e7

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Soluble Interleukin (IL)-15Rα Is Generated by Alternative Splicing or Proteolytic Cleavage and Forms Functional Complexes with IL-15

Autor: Erwin Hans Duitman, Silvia Bulfone-Paus, Vadim Budagian, Hans Krause, Norbert Reiling, René Rückert, Zane Orinska, Elena Bulanova

Publikováno v: Journal of Biological Chemistry. 282:13167-13179

Interleukin 15 (IL-15) is a pleiotropic cytokine that is hardly detectable in biological fluids. Here, we show that IL-15 forms functional heterocomplexes with soluble high affinity IL-15 receptor alpha (IL-15Ralpha) chain in mouse serum and cell-con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8202f4dc44e1490fccd82d1172d7c4a
https://doi.org/10.1074/jbc.m610036200

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Soluble Axl Is Generated by ADAM10-Dependent Cleavage and Associates with Gas6 in Mouse Serum

Autor: Erwin Hans Duitman, Paul Saftig, Zane Orinska, Greg Lemke, Katja Brandt, Vadim Budagian, Elena Bulanova, Silvia Bulfone-Paus, Andreas Ludwig, Dieter Hartmann

Axl receptor tyrosine kinase exists as a transmembrane protein and as a soluble molecule. We show that constitutive and phorbol 12-myristate 13-acetate-induced generation of soluble Axl (sAxl) involves the activity of disintegrin-like metalloproteina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be1798b76385ac301d56fec5c7562cd
https://europepmc.org/articles/PMC3067907/

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Mechanisms of cytokine secretion: a portfolio of distinct pathways allows flexibility in cytokine activity

Autor: Silvia Bulfone-Paus, Zane Orinska, Erwin Hans Duitman

Publikováno v: European journal of cell biology. 90(6-7)

Since cytokines are potent immunoregulators that can determine the fate of an immune response, their expression is tightly regulated at the transcriptional level. Recent research, however, has also revealed complex post-translational mechanisms throu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e5c9325f2945cab658756578658dbc
https://pubmed.ncbi.nlm.nih.gov/21439673

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How a Cytokine Is Chaperoned through the Secretory Pathway by Complexing with Its Own Receptor: Lessons from Interleukin-15 (IL-15)/IL-15 Receptor α

Autor: Zane Orinska, Ralf Paus, Erwin Hans Duitman, Elena Bulanova, Silvia Bulfone-Paus

While it is well appreciated that receptors for secreted cytokines transmit ligand-induced signals, little is known about additional roles for cytokine receptor components in the control of ligand transport and secretion. Here, we show that interleuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07eb5b0ba1b70ac6b7b3b5c80a1a94dc
https://europepmc.org/articles/PMC2863692/

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IL-15 protects intestinal epithelial cells

Autor: Ulrike Strauch, Silvia Kellermeier, Gerhard Rogler, Silvia Bulfone-Paus, J. Bock, Stefan Kiessling, Jürgen Schölmerich, Nadja Dunger, Werner Falk, Martin Hausmann, Erwin Hans Duitman, Hans H Herfarth, Florian Obermeier, Michael Stoeck

Publikováno v: European journal of immunology. 36(10)

IL-15, a T-cell growth factor, has been shown to be increased in inflammatory bowel disease (IBD). It has been suggested that neutralization of IL-15 could protect from T cell-dependent autoimmune inflammation. On the other hand, an anti-apoptotic ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a342a24c8c65e69777a69c2286810ef2
https://pubmed.ncbi.nlm.nih.gov/16981178

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Methods for the preparation of (lipo)peptide synthetases and (lipo)peptides produced therewith

Autor: Johannes Cornelis Leenhouts, Andries Michiel Noback, Lambertus Van Den Burg, Leendert Willem Hamoen, Erwin Hans Duitman, Oscar Kuipers

Publikováno v: University of Groningen

The present invention relates to methods for the preparation of novel lipopeptide synthetases, to the lipopeptide synthetases thus obtained and the lipopeptides that are produced by these synthetases. The method involves modifying at least the lipid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::444c3f7d0be880ad32b1f71e5f8752d3
https://research.rug.nl/en/publications/d0240af8-4a7e-4c9d-a15c-8fc734ec3c68

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