Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Erwin A. van Vliet"'
Autor:
Hester Meeusen, Alessia Romagnolo, Sophie A. C. Holsink, Thijs J. M. van den Broek, Ardy van Helvoort, Jan A. Gorter, Erwin A. van Vliet, J. Martin Verkuyl, Jose P. Silva, Eleonora Aronica
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The classic ketogenic diet is an effective treatment option for drug-resistant epilepsy, but its high fat content challenges patient compliance. Optimizing liver ketone production guided by a method comparing substrates for their ketogenic p
Externí odkaz:
https://doaj.org/article/5a05fe64eed541d3b82a80b52fd6db2e
Autor:
Anatoly Korotkov, Mark J. Luinenburg, Alessia Romagnolo, Till S. Zimmer, Jackelien van Scheppingen, Anika Bongaarts, Diede W. M. Broekaart, Jasper J. Anink, Caroline Mijnsbergen, Floor E. Jansen, Wim van Hecke, Wim G. Spliet, Peter C. van Rijen, Martha Feucht, Johannes A. Hainfellner, Pavel Krsek, Josef Zamecnik, Peter B. Crino, Katarzyna Kotulska, Lieven Lagae, Anna C. Jansen, David J. Kwiatkowski, Sergiusz Jozwiak, Paolo Curatolo, Angelika Mühlebner, Erwin A. van Vliet, James D. Mills, Eleonora Aronica
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 14, Iss 1, Pp 1-16 (2022)
Abstract Background The genetic disorder tuberous sclerosis complex (TSC) is frequently accompanied by the development of neuropsychiatric disorders, including autism spectrum disorder and intellectual disability, with varying degrees of impairment.
Externí odkaz:
https://doaj.org/article/9e33560efb00425a8bb93db1a513ea16
Autor:
Mette Heiskanen, Shalini Das Gupta, James D. Mills, Erwin A. van Vliet, Eppu Manninen, Robert Ciszek, Pedro Andrade, Noora Puhakka, Eleonora Aronica, Asla Pitkänen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2823 (2023)
Traumatic brain injury (TBI) causes 10–20% of structural epilepsies and 5% of all epilepsies. The lack of prognostic biomarkers for post-traumatic epilepsy (PTE) is a major obstacle to the development of anti-epileptogenic treatments. Previous stud
Externí odkaz:
https://doaj.org/article/7cb1f8cc01744e48a0dd32c913752564
Autor:
Jody M. de Jong, Diede W. M. Broekaart, Anika Bongaarts, Angelika Mühlebner, James D. Mills, Erwin A. van Vliet, Eleonora Aronica
Publikováno v:
Biomedicines, Vol 10, Iss 10, p 2475 (2022)
Seizures are one of the most common symptoms of brain tumors. The incidence of seizures differs among brain tumor type, grade, location and size, but paediatric-type diffuse low-grade gliomas/glioneuronal tumors are often highly epileptogenic. The ex
Externí odkaz:
https://doaj.org/article/ddad7a10d64a47d39ac11d970612b7b0
Autor:
Diede W. M. Broekaart, Till S. Zimmer, Sophie T. Cohen, Rianne Tessers, Jasper J. Anink, Helga E. de Vries, Jan A. Gorter, Roger Prades, Eleonora Aronica, Erwin A. van Vliet
Publikováno v:
Biomedicines, Vol 10, Iss 9, p 2117 (2022)
Matrix metalloproteinases (MMPs) are endopeptidases responsible for the cleavage of intra- and extracellular proteins. Several brain MMPs have been implicated in neurological disorders including epilepsy. We recently showed that the novel gelatinase
Externí odkaz:
https://doaj.org/article/0c92e7febbb8401787e3fbba96330229
Autor:
Malgorzata Urbanska, Paulina Kazmierska-Grebowska, Tomasz Kowalczyk, Bartosz Caban, Karolina Nader, Barbara Pijet, Katarzyna Kalita, Agata Gozdz, Herman Devijver, Benoit Lechat, Tomasz Jaworski, Wieslawa Grajkowska, Krzysztof Sadowski, Sergiusz Jozwiak, Katarzyna Kotulska, Jan Konopacki, Fred Van Leuven, Erwin A. van Vliet, Eleonora Aronica, Jacek Jaworski
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 377-387 (2019)
Background: Glycogen synthase kinase-3β (GSK3β) is a key regulator of cellular homeostasis. In neurons, GSK3β contributes to the control of neuronal transmission and plasticity, but its role in epilepsy remains to be defined. Methods: Biochemical
Externí odkaz:
https://doaj.org/article/ccb24ce7f72a4cd2a2d94b67aaf14db7
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Astrocytes are key homeostatic regulators in the central nervous system and play important roles in physiology. After brain damage caused by e.g., status epilepticus, traumatic brain injury, or stroke, astrocytes may adopt a reactive phenotype. This
Externí odkaz:
https://doaj.org/article/cd283a63ea364688977af06e5bdc1431
Autor:
Erwin A. van Vliet, Xavier Ekolle Ndode-Ekane, Lauri J. Lehto, Jan A. Gorter, Pedro Andrade, Eleonora Aronica, Olli Gröhn, Asla Pitkänen
Publikováno v:
Neurobiology of Disease, Vol 145, Iss , Pp 105080- (2020)
Background: Traumatic brain injury (TBI) causes 10–20% of acquired epilepsy, which typically develops within 2 years post-injury with poorly understood mechanisms. We investigated the location, severity, evolution and persistence of blood-brain bar
Externí odkaz:
https://doaj.org/article/6f3e4d520b1e414d9098b12b34618fa2
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
Externí odkaz:
https://doaj.org/article/dcc70ccfcbf848bf9599e169a6ee8fd0
Autor:
Till S. Zimmer, Diede W. M. Broekaart, Victoria-Elisabeth Gruber, Erwin A. van Vliet, Angelika Mühlebner, Eleonora Aronica
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Tuberous sclerosis complex (TSC) represents the prototypic monogenic disorder of the mammalian target of rapamycin (mTOR) pathway dysregulation. It provides the rational mechanistic basis of a direct link between gene mutation and brain pathology (st
Externí odkaz:
https://doaj.org/article/b71256dd378144d6b85023ebc27dd627