Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Erwin, Sigel"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Potassium channels from prokaryotes and eukaryotes are usually recognized by a typical amino acid sequence TXTGY(F)G representing the ionic selectivity filter. Using a screening approach with ion channel family profiles but without the above
Externí odkaz:
https://doaj.org/article/1b1429f81af046fc82b5172f1e3cea90
Autor:
Mauro Serricchio, Adrien W. Schmid, Michael E. Steinmann, Erwin Sigel, Monika Rauch, Daria Julkowska, Serge Bonnefoy, Cécile Fort, Philippe Bastin, Peter Bütikofer
Publikováno v:
Biology Open, Vol 4, Iss 9, Pp 1143-1153 (2015)
The observation that the membranes of flagella are enriched in sterols and sphingolipids has led to the hypothesis that flagella might be enriched in raft-forming lipids. However, a detailed lipidomic analysis of flagellar membranes is not available.
Externí odkaz:
https://doaj.org/article/8651a15f0e1f4f86b81330f48138eeb4
Autor:
Michael E Steinmann, Remo S Schmidt, Juan P Macêdo, Christina Kunz Renggli, Peter Bütikofer, Doris Rentsch, Pascal Mäser, Erwin Sigel
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0188219 (2017)
CLC type anion transport proteins are homo-dimeric or hetero-dimeric with an integrated transport function in each subunit. We have identified and partially characterized three members of this family named TbVCL1, TbVCL2 and TbVCL3 in Trypanosoma bru
Externí odkaz:
https://doaj.org/article/b8f5b4dc76f142b9a17ac11ee4155bf2
Autor:
Roland Baur, Erwin Sigel
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170572 (2017)
The major subunit isoform of GABAA receptors is α1β2γ2. The subunits are thought to surround an ion pore with the counterclockwise arrangement α1γ2β2α1β2 as seen from the outside of the neuron. These receptors have two agonist sites and one h
Externí odkaz:
https://doaj.org/article/c4c9295b78b446799a80fc95a4f15a75
Autor:
Milan Fedurco, Jana Gregorová, Kristýna Šebrlová, Jana Kantorová, Ondřej Peš, Roland Baur, Erwin Sigel, Eva Táborská
Publikováno v:
Biochemistry Research International, Vol 2015 (2015)
The California poppy (Eschscholzia californica Cham.) contains a variety of natural compounds including several alkaloids found exclusively in this plant. Because of the sedative, anxiolytic, and analgesic effects, this herb is currently sold in phar
Externí odkaz:
https://doaj.org/article/09a9f2869ffa48d4a377d39f5d28495f
Autor:
Valentina Carta, Michael Pangerl, Roland Baur, Roshan Puthenkalam, Margot Ernst, Dirk Trauner, Erwin Sigel
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106688 (2014)
γ-Aminobutyric acid type A receptors (GABAA receptors) are chloride ion channels composed of five subunits, mediating fast synaptic and tonic inhibition in the mammalian brain. These receptors show near five-fold symmetry that is most pronounced in
Externí odkaz:
https://doaj.org/article/fc65c12178354a5a966ed4e708d70769
Publikováno v:
PeerJ, Vol 1, p e149 (2013)
NA-glycine is an endogenous lipid molecule with analgesic properties, which is structurally similar to the endocannabinoids 2-AG and anandamide but does not interact with cannabinoid receptors. NA-glycine has been suggested to act at the G-protein co
Externí odkaz:
https://doaj.org/article/2f5bf80dedd94b20a93a8b51593a4ddf
Autor:
Lucien Rufener, Nicola Bedoni, Roland Baur, Samantha Rey, Dominique A Glauser, Jacques Bouvier, Robin Beech, Erwin Sigel, Alessandro Puoti
Publikováno v:
PLoS Pathogens, Vol 9, Iss 8, p e1003524 (2013)
Monepantel is a member of the recently identified class of anthelmintics known as the amino-acetonitrile derivatives (AADs). Monepantel controls all major gastro-intestinal nematodes in sheep including those that are resistant to the classical anthel
Externí odkaz:
https://doaj.org/article/7666d14c819444b495de9c1727116a05
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e42101 (2012)
Classical benzodiazepines, such as diazepam, interact with α(x)β(2)γ(2) GABA(A) receptors, x = 1, 2, 3, 5 and modulate their function. Modulation of different receptor isoforms probably results in selective behavioural effects as sedation and anxi
Externí odkaz:
https://doaj.org/article/b827e7fc0bfa4590b5ab484170e87469
Autor:
Margot Ernst, Erwin Sigel
Publikováno v:
Trends in Pharmacological Sciences. 39:659-671
Everyday activity is based on a subtle equilibrium of excitatory and inhibitory neuronal systems. The most prominent players in neuronal inhibition are synaptic and extrasynaptic GABAA receptors. Benzodiazepines are popular drugs that act as positive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b02084781543777a8d5c473c62f7535
https://doi.org/10.1016/j.tips.2018.03.006
https://doi.org/10.1016/j.tips.2018.03.006