α-Synuclein Lowers p53-dependent Apoptotic Response of Neuronal Cells

Autor: Erwan Paitel, Frédéric Checler, Cristine Alves da Costa, Bruno Vincent

Publikováno v: Journal of Biological Chemistry. 277:50980-50984

We have examined the influence of α-synuclein on the responsiveness of TSM1 neuronal cells to apoptotic stimulus. We show that α-synuclein drastically lowers basal and staurosporine-stimulated caspase 3 immunoreactivity and activity. This is accomp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ab24e7cd4ca0cf6c25a80acbc2cd6bd
https://doi.org/10.1074/jbc.m207825200

Métabolisme du précurseur du peptide amyloïde et présénilines

Autor: Bruno Vincent, Frédéric Checler, Cécile Dumanchin-Njock, Elvira Lopez-Perez, Erwan Paitel, Cristine Alves da Costa, Philippe Marambaud, Agnès Petit

Publikováno v: médecine/sciences. 18:717-724

La production exacerbee de peptide amyloide contribue vraisemblablement a l’etiologie de la maladie d’Alzheimer. En effet, ce peptide s’accumule, s’agrege et conduit aux depots proteiques -les plaques seniles - qui envahissent le cortex des p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23f2e909d376c378186aad99043fec72
https://doi.org/10.1051/medsci/20021867717

Cortical neuronal and glial pathology in TgTauP301L transgenic mice: neuronal degeneration, memory disturbance, and phenotypic variation

Autor: Tetsuro, Murakami, Erwan, Paitel, Takeshi, Kawarabayashi, Masaki, Ikeda, M Azhar, Chishti, Christopher, Janus, Etsuro, Matsubara, Atsushi, Sasaki, Toshitaka, Kawarai, Amie L, Phinney, Yasuo, Harigaya, Patrick, Horne, Nobuaki, Egashira, Kenichi, Mishima, Amanda, Hanna, Jing, Yang, Katsunori, Iwasaki, Mitsuo, Takahashi, Michihiro, Fujiwara, Koichi, Ishiguro, Catherine, Bergeron, George A, Carlson, Koji, Abe, David, Westaway, Peter, St George-Hyslop, Mikio, Shoji

Publikováno v: The American journal of pathology. 169(4)

Recapitulation of tau pathologies in an animal model has been a long-standing goal in neurodegenerative disease research. We generated transgenic (TgTauP301L) mice expressing a frontotemporal dementia with parkinsonism linked to chromosome 17 (FTPD-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2788174e40e84ea8a1219611f8cb0c47
https://pubmed.ncbi.nlm.nih.gov/17003492

Primary cultured neurons devoid of cellular prion display lower responsiveness to staurosporine through the control of p53 at both transcriptional and post-transcriptional levels

Autor: Erwan Paitel, Frédéric Checler, Cristine Alves da Costa, Bruno Vincent, Jean-Christophe Bourdon, Claire Sunyach

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279, pp.612-618

We assessed the contribution of the cellular prion protein (PrPc) in the control of neuronal apoptosis by examining cell death in both human cells and murine primary cultured neurons. We first confirmed our previous finding that staurosporine-induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c0382eeb72bcf662b23b2e28b70e53
https://pubmed.ncbi.nlm.nih.gov/14570892

Alpha-synuclein lowers p53-dependent apoptotic response of neuronal cells. Abolishment by 6-hydroxydopamine and implication for Parkinson's disease

Autor: Cristine, Alves Da Costa, Erwan, Paitel, Bruno, Vincent, Frédéric, Checler

Publikováno v: The Journal of biological chemistry. 277(52)

We have examined the influence of alpha-synuclein on the responsiveness of TSM1 neuronal cells to apoptotic stimulus. We show that alpha-synuclein drastically lowers basal and staurosporine-stimulated caspase 3 immunoreactivity and activity. This is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::435f9ebc12f9286b15bb3fc08c78c4ad
https://pubmed.ncbi.nlm.nih.gov/12397073