Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ertuǧrul M. Özbudak"'
Autor:
Asuman Koparir, Caroline Lekszas, Kemal Keseroglu, Thalia Rose, Lena Rappl, Aboulfazl Rad, Reza Maroofian, Nakul Narendran, Atefeh Hasanzadeh, Ehsan Ghayoor Karimiani, Felix Boschann, Uwe Kornak, Eva Klopocki, Ertuğrul M. Özbudak, Barbara Vona, Thomas Haaf, Daniel Liedtke
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-13 (2024)
Abstract Background/Objectives Rare genetic disorders causing specific congenital developmental abnormalities often manifest in single families. Investigation of disease-causing molecular features are most times lacking, although these investigations
Externí odkaz:
https://doaj.org/article/4ca8372a9ecd42798f65bafe5883ded4
Autor:
Kemal Keseroglu, Oriana Q. H. Zinani, Sevdenur Keskin, Hannah Seawall, Eslim E. Alpay, Ertuğrul M. Özbudak
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
Abstract Mutations of several genes cause incomplete penetrance and variable expressivity of phenotypes, which are usually attributed to modifier genes or gene-environment interactions. Here, we show stochastic gene expression underlies the variabili
Externí odkaz:
https://doaj.org/article/c65165bd15f749a28627def134f94a5b
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102020- (2023)
Summary: Taming gene expression variability is critical for robust pattern formation during embryonic development. Here, we describe an optimized protocol for single-molecule fluorescence in situ hybridization and immunohistochemistry in zebrafish em
Externí odkaz:
https://doaj.org/article/2064be50832646ce8060de62805b1e0e
Publikováno v:
Open Biology, Vol 12, Iss 10 (2022)
Metazoan embryos develop from a single cell into three-dimensional structured organisms while groups of genetically identical cells attain specialized identities. Cells of the developing embryo both create and accurately interpret morphogen gradients
Externí odkaz:
https://doaj.org/article/82baf4797f7448b7ab81862929e9374b
Autor:
Oriana Q.H. Zinani, Kemal Keseroğlu, Supravat Dey, Ahmet Ay, Abhyudai Singh, Ertuğrul M. Özbudak
Publikováno v:
iScience, Vol 25, Iss 7, Pp 104579- (2022)
Summary: Timely progression of a genetic program is critical for embryonic development. However, gene expression involves inevitable fluctuations in biochemical reactions leading to substantial cell-to-cell variability (gene expression noise). One of
Externí odkaz:
https://doaj.org/article/c52e2d2f6919491285970530d2d348c2
Publikováno v:
Biology Open, Vol 2, Iss 5, Pp 505-514 (2013)
Summary Vertebrate muscle development occurs through sequential differentiation of cells residing in somitic mesoderm – a process that is largely governed by transcriptional regulators. Our recent spatiotemporal microarray study in zebrafish has id
Externí odkaz:
https://doaj.org/article/f369b7e83d6545b5a0e95da604206569
Autor:
Julian Lewis, Ertuǧrul M. Özbudak
Publikováno v:
Developmental Dynamics. 236:1410-1415
The regular pattern of somite segmentation depends on a clock, the somite segmentation clock, in the form of a gene expression oscillator, operating in the presomitic mesoderm (the PSM) at the tail end of the vertebrate embryo. Genetic screens and ot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304e2384e27631a8569121e4e1237a0d
https://doi.org/10.1002/dvdy.21154
https://doi.org/10.1002/dvdy.21154
Autor:
Martin Gajewski, Ertuǧrul M. Özbudak, Julian Lewis, Suma Choorapoikayil, Anja Hanisch, Maxine V. Holder
Publikováno v:
Development (Cambridge, England). 140(2)
A gene expression oscillator called the segmentation clock controls somite segmentation in the vertebrate embryo. In zebrafish, the oscillatory transcriptional repressor genes her1 and her7 are crucial for genesis of the oscillations, which are thoug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4425af8744c470fa184a2381a0ce364f
https://pubmed.ncbi.nlm.nih.gov/23250218
https://pubmed.ncbi.nlm.nih.gov/23250218
Autor:
Sevdenur Keskin, M. Fethullah Simsek, Ha T. Vu, Carlton Yang, Stephen H. Devoto, Ahmet Ay, Ertuğrul M. Özbudak
Publikováno v:
iScience, Vol 12, Iss , Pp 247-259 (2019)
Summary: Gene regulatory networks govern pattern formation and differentiation during embryonic development. Segmentation of somites, precursors of the vertebral column among other tissues, is jointly controlled by temporal signals from the segmentat
Externí odkaz:
https://doaj.org/article/5c0e98c1f81740fab8ec45c0e02aa896
Publikováno v:
Cell Reports, Vol 24, Iss 1, Pp 66-78.e8 (2018)
Summary: Signal gradients encode instructive information for numerous decision-making processes during embryonic development. A striking example of precise, scalable tissue-level patterning is the segmentation of somites—the precursors of the verte
Externí odkaz:
https://doaj.org/article/1c85c0f8e77c4519aa6dfe545dd363ba