Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ertong Li"'
Autor:
Wenbin Liu, Ertong Li, Lingyan Liu, Fangyuan Tian, Xiongming Luo, Yanqu Cai, Jie Wang, Xiaobao Jin
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e17777- (2023)
Invasive fungal infections are on the rise, leading to a continuous demand for antifungal antibiotics. Rare actinomycetes have been shown to contain a variety of interesting compounds worth exploring. In this study, 15 strains of rare actinobacterium
Externí odkaz:
https://doaj.org/article/54794d95f81c4e60bd36222d42391e64
Autor:
Aolin Jia, Shijia Huang, Wen Song, Junli Wang, Yonggang Meng, Yue Sun, Lina Xu, Henriette Laessle, Jan Jirschitzka, Jiao Hou, Tiantian Zhang, Wenquan Yu, Giuliana Hessler, Ertong Li, Shoucai Ma, Dongli Yu, Jan Gebauer, Ulrich Baumann, Xiaohui Liu, Zhifu Han, Junbiao Chang, Jane E. Parker, Jijie Chai
Publikováno v:
Science (New York, N.Y.). 377(6605)
Plant pathogen-activated immune signaling by nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal Toll/Interleukin-1 receptor (TIR) domain converges on Enhanced Disease Susceptibility 1 (EDS1) and its direct partners Phytoalexin
Autor:
Du Jinfa, Youmei Peng, Yonggang Meng, Kaikai Zhu, Bin Yu, He Huang, Yongfang Yao, Junbiao Chang, Wenquan Yu, Ertong Li, Dongxu Yi, Kai Wang, Chuanjun Song
Publikováno v:
Journal of Medicinal Chemistry. 64:925-937
Osimertinib is a highly potent and selective third-generation epidermal growth factor receptor (EGFR) inhibitor, which provides excellent clinical benefits and is now a standard-of-care therapy for advanced EGFR mutation-positive non-small-cell lung
Autor:
Alexander Förderer, Ertong Li, Aaron Lawson, Ya-nan Deng, Yue Sun, Elke Logemann, Xiaoxiao Zhang, Jie Wen, Zhifu Han, Junbiao Chang, Yuhang Chen, Paul Schulze-Lefert, Jijie Chai
Publikováno v:
Nature
Plant intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) detect pathogen effectors to trigger immune responses1. Indirect recognition of a pathogen effector by the dicotyledonous Arabidopsis thaliana coiled-coil domain containing N
Publikováno v:
Current Opinion in Plant Biology. 67:102212
Nucleotide-binding and leucine-rich repeat (NLR) proteins are a large family of intracellular immune receptors that detect specific pathogen effector proteins secreted into plant cells. Upon direct or indirect recognition of effector proteins, NLRs f
Autor:
Dongli Yu, Wen Song, Eddie Yong Jun Tan, Li Liu, Yu Cao, Jan Jirschitzka, Ertong Li, Elke Logemann, Chenrui Xu, Shijia Huang, Aolin Jia, Xiaoyu Chang, Zhifu Han, Bin Wu, Paul Schulze-Lefert, Jijie Chai
Publikováno v:
Cell. 185:2370-2386.e18
2',3'-cAMP is a positional isomer of the well-established second messenger 3',5'-cAMP, but little is known about the biology of this noncanonical cyclic nucleotide monophosphate (cNMP). Toll/interleukin-1 receptor (TIR) domains of nucleotide-binding
Autor:
Junbiao Chang, Jian-Hua Wang, Qingduan Wang, Youmei Peng, Zhifu Han, Li Sun, Lan Liang, Meng-Li Wu, Bailing Zhang, Jiao Hou, Yan Qiao, Dongwei Zhang, Wenquan Yu, Jijie Chai, Xia Jin, Ertong Li, Jingyu Chen, Yan Zhang, Zhiwei Huang, Chuanjun Song, Qing-Xia Zhao
Publikováno v:
Journal of medicinal chemistry. 63(15)
In preclinical and phase I and II clinical studies, 2'-deoxy-2'-β-fluoro-4'-azidocytidine (FNC) displays a potent and long-lasting inhibition of HIV-1 infection. To investigate its mechanism of action, we compared it with the well-documented lamivud
Publikováno v:
Tetrahedron. 74:4613-4618
A reaction involving an efficient NBS-mediated oxidative N‒O bond formation has been established for the synthesis of 1,2,4-oxadiazoles from readily accessible N-acyl amidines. The features of this synthetic method include simplicity of operation,
Autor:
Youmei Peng, Junbiao Chang, Yafeng Wang, Qingduan Wang, Jinfeng Kang, Jinhua Jiang, Ertong Li, Bingjie Liu, Longyu Li, Wenquan Yu, Jie Wu, Qinghua Yang, Jingmin Zhang
Publikováno v:
Journal of Medicinal Chemistry. 59:3661-3670
We report a series of novel O-(substituted benzyl) phosphoramidate prodrugs of 5-fluoro-2'-deoxyuridine for the treatment of hepatocellular carcinoma. Through structure optimization, the o-methylbenzyl analog (1t) was identified as an orally bioavail
Autor:
Jie Wu, Ertong Li, Zhigang Lv, Wenquan Yu, Yangxue Liu, Lina Song, Xianhai Tian, Junbiao Chang
Publikováno v:
The Journal of Organic Chemistry. 80:7219-7225
An I2/KI-mediated oxidative N-N bond formation reaction is described. This new and environmentally benign approach allows for the convenient synthesis of a variety of 1,2,4-triazolo[1,5-a]pyridines and other 1,5-fused 1,2,4-triazoles from readily ava