Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Errol L G, Samuel"'
Publikováno v:
Journal of Cheminformatics, Vol 13, Iss 1, Pp 1-11 (2021)
Abstract The thermal shift assay (TSA)—also known as differential scanning fluorimetry (DSF), thermofluor, and Tm shift—is one of the most popular biophysical screening techniques used in fragment-based ligand discovery (FBLD) to detect protein
Externí odkaz:
https://doaj.org/article/716f45629e2b4f94b161dcee7038bf05
Autor:
Lyra Chang, James Campbell, Idris O. Raji, Shiva K. R. Guduru, Prasanna Kandel, Michelle Nguyen, Steven Liu, Kevin Tran, Navneet K. Venugopal, Bethany C. Taylor, Matthew V. Holt, Nicolas L. Young, Errol L. G. Samuel, Prashi Jain, Conrad Santini, Banumathi Sankaran, Kevin R. MacKenzie, Damian W. Young
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract Despite the established roles of the epigenetic factor UHRF1 in oncogenesis, no UHRF1-targeting therapeutics have been reported to date. In this study, we use fragment-based ligand discovery to identify novel scaffolds for targeting the isol
Externí odkaz:
https://doaj.org/article/5972f93c7d5b4a20bcf0f3bca4897227
Autor:
Carolina J. Garcia Garcia, James M. Tour, Wai Kin Chan, Aaron J. Grossberg, Tara N. Fujimoto, Philip L. Lorenzi, Robert Dantzer, Daniel Lin, Thomas D. Horvath, Jessica M. Molkentine, Cullen M. Taniguchi, Kathy A. Mason, Marimar de la Cruz Bonilla, Errol L. G. Samuel, Helen Piwnica-Worms, Amit Deorukhkar
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Unresectable pancreatic cancer is almost universally lethal because chemotherapy and radiation cannot completely stop the growth of the cancer. The major problem with using radiation to approximate surgery in unresectable disease is that the radiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7932d6aed0e868ea3187442632119aaf
https://doi.org/10.1038/s41598-018-37147-9
https://doi.org/10.1038/s41598-018-37147-9
Autor:
Taeko Inoue, Simone Hernandez Ruano, Gary R. Stinnett, Christine Beeton, Robia G. Pautler, Redwan Huq, Errol L. G. Samuel, Tabassum Majid, James M. Tour, Deric M. Griffin
Publikováno v:
NMR in Biomedicine. 29:1436-1444
In many human diseases, the presence of inflammation is associated with an increase in the level of reactive oxygen species (ROS). The resulting state of oxidative stress is highly detrimental and can initiate a cascade of events that ultimately lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0782af4055b1ffacac7da08efb35bf19
https://doi.org/10.1002/nbm.3565
https://doi.org/10.1002/nbm.3565
Autor:
Wai Kin Chan, Aaron J. Grossberg, Errol L. G. Samuel, Philip L. Lorenzi, Amit Deorukhkar, Kathy A. Mason, Jessica M. Molkentine, Robert Dantzer, Thomas D. Horvath, James M. Tour, Tara N. Fujimoto, Cullen M. Taniguchi
Unresectable pancreatic cancer is almost universally lethal because chemotherapy and radiation cannot completely stop the growth of the cancer. The major problem with using radiation to approximate surgery in unresectable disease is that the radiatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39350a7e6468e3ff273f5799953101e5
https://doi.org/10.1101/289074
https://doi.org/10.1101/289074
Autor:
Daniela C. Marcano, James M. Tour, Tianshu Yang, David B. Corry, Xiaoyi Yuan, Errol L. G. Samuel, Farrah Kheradmand, William K.A. Sikkema, Antony Rodriguez, Ran You, Wen Lu
Publikováno v:
Nature immunology
Smoking-related emphysema is a chronic inflammatory disease driven by the T(H)17 subset of helper T cells through molecular mechanisms that remain obscure. Here we explored the role of the microRNA miR-22 in emphysema. We found that miR-22 was upregu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89777660b016e7a5aaebac0796d5f672
http://europepmc.org/articles/PMC4597310
http://europepmc.org/articles/PMC4597310
Autor:
James M. Tour, Xiujun Fan, Yongji Gong, Errol L. G. Samuel, Ruquan Ye, Gonglan Ye, Huilong Fei, Zhiwei Peng, Pulickel M. Ajayan
Publikováno v:
ACS Nano. 8:10837-10843
The scarcity and high cost of platinum-based electrocatalysts for the oxygen reduction reaction (ORR) has limited the commercial and scalable use of fuel cells. Heteroatom-doped nanocarbon materials have been demonstrated to be efficient alternative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd646a2c71ce9c41d72ea5edbe485c5b
https://doi.org/10.1021/nn504637y
https://doi.org/10.1021/nn504637y
Autor:
Brittany R. Bitner, Thomas A. Kent, James M. Tour, Errol L. G. Samuel, My Linh T. Duong, Daniela C. Marcano
Publikováno v:
Trends in Biotechnology. 32:501-505
Oxidative stress reflects an excessive accumulation of reactive oxygen species (ROS) and is a hallmark of several acute and chronic human pathologies. Although many antioxidants have been investigated, most have demonstrated poor efficacy in clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39f60d3330c14070c495f59ae831118
https://doi.org/10.1016/j.tibtech.2014.08.005
https://doi.org/10.1016/j.tibtech.2014.08.005
Autor:
Abdul-Rahman O. Raji, Errol L. G. Samuel, James M. Tour, Vladimir Volman, Sydney Salters, Yu Zhu
Publikováno v:
ACS Applied Materials & Interfaces. 6:16661-16668
We report that conductive films made from hexadecylated graphene nanoribbons (HD-GNRs) can have high transparency to radiofrequency (RF) waves even at very high incident power density. Nanoscale-thick HD-GNR films with an area of several square centi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d166684f21b6dde22f267eb8c89d204e
https://doi.org/10.1021/am503478w
https://doi.org/10.1021/am503478w
Autor:
Zheng Yan, Zhiwei Peng, Gilberto Casillas, Jian Lin, Changsheng Xiang, Haiqing Zhou, Yang Yang, Gedeng Ruan, Abdul-Rahman O. Raji, Errol L. G. Samuel, Robert H. Hauge, Miguel Jose Yacaman, James M. Tour
Publikováno v:
ACS Nano
ACS nano, vol 8, iss 5
ACS nano, vol 8, iss 5
As the cylindrical sp(2)-bonded carbon allotrope, carbon nanotubes (CNTs) have been widely used to reinforce bulk materials such as polymers, ceramics, and metals. However, both the concept demonstration and the fundamental understanding on how 1D CN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdef0bc47e839cd172a58e962227e05
https://doi.org/10.1021/nn501132n
https://doi.org/10.1021/nn501132n