Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Erqian Na"'
Autor:
Esther Latres, Jason Mastaitis, Wen Fury, Lawrence Miloscio, Jesus Trejos, Jeffrey Pangilinan, Haruka Okamoto, Katie Cavino, Erqian Na, Angelos Papatheodorou, Tobias Willer, Yu Bai, Jee Hae Kim, Ashique Rafique, Stephen Jaspers, Trevor Stitt, Andrew J. Murphy, George D. Yancopoulos, Jesper Gromada
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Inhibition of GDF8 increases muscle mass in mice, but is less effective in monkeys and humans. Here the authors show that activin A also inhibits muscle hypertrophy and that concomitant inhibition of activin A and GDF8 synergistically increases muscl
Externí odkaz:
https://doaj.org/article/27340da65b5f447ab24e6f3d810b70d9
Autor:
Katie Cavino, Jesper Gromada, Qi Su, Haruka Okamoto, Jinrang Kim, Erqian Na, Biin Sung, Xiping Cheng
Publikováno v:
Endocrinology. 162(1)
The liver plays a critical role in maintaining ammonia homeostasis. Urea cycle defects, liver injury, or failure and glutamine synthetase (GS) deficiency result in hyperammonemia, serious clinical conditions, and lethality. In this study we used a mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd714c4b23bf3009b89b0ac524a2209
https://pubmed.ncbi.nlm.nih.gov/33206168
https://pubmed.ncbi.nlm.nih.gov/33206168
Autor:
Sun Y. Kim, Elizabeth A. Krumm, Andrew J. Murphy, Katie Cavino, Haruka Okamoto, Erqian Na, Jesper Gromada, Xiping Cheng, George D. Yancopoulos
Publikováno v:
Proceedings of the National Academy of Sciences. 114:2753-2758
Inactivating mutations in the insulin receptor results in extreme insulin resistance. The resulting hyperglycemia is very difficult to treat, and patients are at risk for early morbidity and mortality from complications of diabetes. We used the insul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1352c1f456a4b2beb6553d5b32c6ff33
https://doi.org/10.1073/pnas.1621069114
https://doi.org/10.1073/pnas.1621069114
Autor:
Ramandeep Bhavsar, Jesper Gromada, Katie Cavino, Erqian Na, Giselle Dominguez-Gutierrez, George D. Yancopoulos, Ming Hu, Bezawit Megra, Yurong Xin, Brian Zambrowicz, Pauline Chabosseau, Rojas Jose F, Sandra Kleiner, Guy A. Rutter, Andrew J. Murphy, Gaelle Carrat, Daniel Gomez
Publikováno v:
E7649
E7642
Proceedings of the National Academy of Sciences of the United States of America
E7642
Proceedings of the National Academy of Sciences of the United States of America
Significance The zinc transporter SLC30A8 is primarily expressed in islets of the endocrine pancreas. Human SLC30A8 loss-of-function mutations protect against type 2 diabetes. However, Slc30a8 knockout mice do not show this protection. We have genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e83aa4736f9d02bd5c7d98cddb66a9
http://hdl.handle.net/10044/1/62724
http://hdl.handle.net/10044/1/62724
Autor:
Guillermo Anguiano, Brian Zambrowicz, Haruka Okamoto, Wen Hong Li, Jesper Gromada, Jinrang Kim, Shiuhwei Chen, Erqian Na, Qing Liu, George D. Yancopoulos, Joseph Lee, Yurong Xin, Zhi Jiang Huang, Roger H Unger, Katie Cavino, Yan Xu, Rachid Hamid, Andrew J. Murphy
Publikováno v:
Cell Metab
Glucagon supports glucose homeostasis by stimulating hepatic gluconeogenesis, in part by promoting the uptake and conversion of amino acids into gluconeogenic precursors. Genetic disruption or pharmacologic inhibition of glucagon signaling results in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356579be3eed17f64bc54e8fc18a0a87
https://europepmc.org/articles/PMC8206958/
https://europepmc.org/articles/PMC8206958/
Autor:
Jason Mastaitis, Andrew J. Murphy, Jesus A. Trejos, Stephen Jaspers, Jeffrey Pangilinan, Trevor Stitt, Erqian Na, Esther Latres, Yu Bai, George D. Yancopoulos, Lawrence Miloscio, Jesper Gromada, Ashique Rafique, Wen Fury, Jee Hae Kim, Tobias Willer, Katie Cavino, Haruka Okamoto, Angelos Papatheodorou
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Growth and differentiation factor 8 (GDF8) is a TGF-β superfamily member, and negative regulator of skeletal muscle mass. GDF8 inhibition results in prominent muscle growth in mice, but less impressive hypertrophy in primates, including man. Broad T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87739244226941d93603a7a609426820
https://doi.org/10.1038/ncomms15153
https://doi.org/10.1038/ncomms15153
Autor:
Jesper Gromada, Haruka Okamoto, Panayiotis Stevis, Katie Cavino, George D. Yancopoulos, Elizabeth A. Krumm, Erqian Na, Joyce Harp, Andrew J. Murphy, Steven Kim
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(10)
Genetic disruption or pharmacologic inhibition of glucagon signaling effectively lowers blood glucose but results in compensatory glucagon hypersecretion involving expansion of pancreatic α-cell mass. Ben-Zvi et al. recently reported that angiopoiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48d80757b26e05cb3a72a1a2eb75dba
https://pubmed.ncbi.nlm.nih.gov/28283660
https://pubmed.ncbi.nlm.nih.gov/28283660
Autor:
Andrew J. Murphy, Susan Bonner-Weir, Helen H. Hobbs, Viktoria Gusarova, Jesper Gromada, Yurong Xin, Jonathan C. Cohen, Erqian Na, Corey A. Alexa, George D. Yancopoulos, Panayiotis Stevis
Publikováno v:
Cell. 159:691-696
Yi et al. (2013) recently reported that angiopoietin-like protein 8 (ANGPTL8) was the long-sought “betatrophin” that could control pancreatic beta cell proliferation. However, studies of Angptl8−/− mice revealed profound reduction of triglyce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aae902344ad060a0604709558e136b
https://doi.org/10.1016/j.cell.2014.09.027
https://doi.org/10.1016/j.cell.2014.09.027
Autor:
Jinrang Kim, Yurong Xin, Erqian Na, Jesper Gromada, Min Ni, Andrew J. Murphy, George D. Yancopoulos, Calvin Lin, Christina Adler, Haruka Okamoto, Katie Cavino
Publikováno v:
Endocrinology. 157(9)
Aging improves pancreatic β-cell function in mice. This is a surprising finding because aging is typically associated with functional decline. We performed single-cell RNA sequencing of β-cells from 3- and 26-month-old mice to explore how changes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::708578e59ba6fd08484c5d1794d86a0b
https://pubmed.ncbi.nlm.nih.gov/27466694
https://pubmed.ncbi.nlm.nih.gov/27466694
Autor:
Calvin Lin, George D. Yancopoulos, Trevor Stitt, Erqian Na, Terra Potocky, Andrew J. Murphy, Roy Bauerlein, Ying Huang, Jesper Gromada, Jeffrey Pangilinan, Ashique Rafique, Lawrence Miloscio, Mark Eckersdorff, Jason Mastaitis, Esther Latres
Publikováno v:
Skeletal Muscle
Background Loss of skeletal muscle mass and function in humans is associated with significant morbidity and mortality. The role of myostatin as a key negative regulator of skeletal muscle mass and function has supported the concept that inactivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74fe5eeba57ddc6f17d3abd6ce4487a
https://doi.org/10.1186/s13395-015-0060-8
https://doi.org/10.1186/s13395-015-0060-8