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Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire

Autor: David A. Hildeman, Carla M. Cuda, Kathrin Kalies, Harris Perlman, Eron Roy, Anke Fähnrich, Kun-Po Li, H. Leighton Grimes

Publikováno v: The Journal of Immunology. 198:257-269

CD8αα TCRαβ+ intestinal intraepithelial lymphocytes play a critical role in promoting intestinal homeostasis, although mechanisms controlling their development and peripheral homeostasis remain unclear. In this study, we examined the spatiotempor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc91643af96a1102daa6ef576b9a5dd
https://doi.org/10.4049/jimmunol.1601200

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Temporal expression of Bim limits the development and repertoire of TCR+ double negative thymocytes and CD8αα intestinal intraepithelial lymphocytes

Autor: Kun-Po Li, Anke Fähnrich, Eron Roy, Carla Cuda, H Leighton Grimes, Harris Perlman, Kathrin Kalies, David A Hildeman

Publikováno v: The Journal of Immunology. 196:121.9-121.9

DN T cells (CD4−CD8α−TCRαβ+) and CD8αα T cells compose a major lymphocyte population in the intestine and promote gut homeostasis. Their thymic development, i.e. agonist selection, has been shown to be controlled by the pro-apoptotic factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30e0ae817c7afe2c72b2d72a6d2cb104
https://doi.org/10.4049/jimmunol.196.supp.121.9

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Bim expression in early DP thymocytes limits development of TCRαβ+DN thymocytes and CD8αα intestinal intraepithelial lymphocytes (HEM2P.243)

Autor: Kun-Po Li, Eron Roy, Carla Cuda, H Grimes, Harris Perlman, David Hildeman

Publikováno v: The Journal of Immunology. 194:51.13-51.13

Thymocyte negative selection is thought to cull T cells with strong self-reactivity and maintain T cells with non-self-specificity. While initial work implicated Bim as a critical mediator of thymocyte negative selection, its role in the process has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::498f03560dc0ae983d666dfd3b7708ba
https://doi.org/10.4049/jimmunol.194.supp.51.13

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Defects in pro-apoptotic genes, Bim or Bax/Bak, cause accumulation of TCRβhi DN4 cells in thymus (HEM4P.241)

Autor: Kun-Po Li, Eron Roy, David Hildeman

Publikováno v: The Journal of Immunology. 192:116.17-116.17

Regulated induction of apoptosis during thymocyte development is critical to prevent the generation of self-reactive T cells whilst maintaining a repertoire of T cells that can promote protective immunity. Although the pro-apoptotic Bcl-2 family memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3db04370126229b3058da02c23e7a283
https://doi.org/10.4049/jimmunol.192.supp.116.17

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Monophosphate Lipid A's TRIF-biased TLR4 signaling results in weak NLRP3 inflammasome priming and reduced IL1beta production, leading to decreased inflammation in vivo compared to Lipid A. (136.38)

Autor: Chelsea Eaves, Luigi Franchi, Eron Roy, Gabriel Nunez, Thomas Mitchell

Publikováno v: The Journal of Immunology. 184:136.38-136.38

Monophosphate Lipid A (MLA), a PAMP variant of the Lipid A moiety from LPS, exhibits 100-fold reduced toxicity than its parent molecule. We previously characterized MLA as TRIF-biased agonists of TLR4, meaning that while inductions of TRIF-dependent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc4567164158f1f6718293014e33f1c8
https://doi.org/10.4049/jimmunol.184.supp.136.38

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