Zobrazeno 1 - 10
of 4 271
pro vyhledávání: '"Ernst W"'
Autor:
Harim I. Won, Samuel Zinga, Olga Kandror, Tatos Akopian, Ian D. Wolf, Jessica T. P. Schweber, Ernst W. Schmid, Michael C. Chao, Maya Waldor, Eric J. Rubin, Junhao Zhu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Proteolysis-targeting chimeras (PROTACs) represent a new therapeutic modality involving selectively directing disease-causing proteins for degradation through proteolytic systems. Our ability to exploit targeted protein degradation (TPD) for
Externí odkaz:
https://doaj.org/article/b9ac70b36b4b4800bd5cfffe2f4e65d9
Autor:
Thomas Öhlinger, Ernst W. Müllner, Magdalena Fritz, Maike Werning, Joanna Baron-Stefaniak, Christof Jungbauer, David M. Baron, Ulrich Salzer
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Storage of packed red blood cells is associated with changes in erythrocytes that over time increasingly impair cellular function and potentially contribute to adverse effects associated with blood transfusion. Exposure of phosphatidylserine at the o
Externí odkaz:
https://doaj.org/article/ecf46cb129fd42cc9c797373e7bdf13e
Autor:
Peter J. Mullen, Gustavo Garcia, Arunima Purkayastha, Nedas Matulionis, Ernst W. Schmid, Milica Momcilovic, Chandani Sen, Justin Langerman, Arunachalam Ramaiah, David B. Shackelford, Robert Damoiseaux, Samuel W. French, Kathrin Plath, Brigitte N. Gomperts, Vaithilingaraja Arumugaswami, Heather R. Christofk
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The pandemic of COVID-19, caused by SARS-CoV-2 infection, warrants immediate investigation for therapy options. Here the authors show, using epithelial and air-liquid interface cultures, that SARS-CoV-2 hijacks host cell metabolism to facilitate vira
Externí odkaz:
https://doaj.org/article/fb48f36f0ee14f8194aa51fcf0be0cc6
Autor:
Maike Werning, Ernst W. Müllner, Georg Mlynek, Verena Dobretzberger, Kristina Djinovic‐Carugo, David M. Baron, Holger Prokisch, Boriana Büchner, Thomas Klopstock, Ulrich Salzer
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 8, Pp 1340-1351 (2020)
Abstract Objective Pantothenate kinase 2‐associated neurodegeneration (PKAN) is a rare neurodegenerative disease caused by mutations in the pantothenate kinase 2 (PANK2) gene. PKAN is associated with iron deposition in the basal ganglia and, occasi
Externí odkaz:
https://doaj.org/article/aff0f4c836c947da90e401b44024d4bb
Autor:
Michael Eigenschink, Danylo Savran, Christoph P. Zitterer, Sebastian Granitzer, Magdalena Fritz, David M. Baron, Ernst W. Müllner, Ulrich Salzer
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Ascorbic acid (AA; or vitamin C) is an important physiological antioxidant and radical scavenger. Some mammalian species, including homo sapiens, have lost the ability to synthetize AA and depend on its nutritional uptake. Erythrocytes from AA-auxotr
Externí odkaz:
https://doaj.org/article/988542e3883740d689841923dde0302b
Autor:
Antonio Uccelli, Alice Laroni, Lou Brundin, Michel Clanet, Oscar Fernandez, Seyed Massood Nabavi, Paolo A. Muraro, Roberto S. Oliveri, Ernst W. Radue, Johann Sellner, Per Soelberg Sorensen, Maria Pia Sormani, Jens Thomas Wuerfel, Mario A. Battaglia, Mark S. Freedman, on behalf of the MESEMS study group
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-13 (2019)
Abstract Background Multiple sclerosis (MS) is an inflammatory disease of the central nervous system with a degenerative component, leading to irreversible disability. Mesenchymal stem cells (MSC) have been shown to prevent inflammation and neurodege
Externí odkaz:
https://doaj.org/article/cecb42ab3b814fa7b6f5dace14d6516b
Autor:
Maike Werning, Verena Dobretzberger, Martin Brenner, Ernst W. Müllner, Georg Mlynek, Kristina Djinovic-Carugo, David M. Baron, Lena Fragner, Almut T. Bischoff, Boriana Büchner, Thomas Klopstock, Wolfram Weckwerth, Ulrich Salzer
Publikováno v:
Biomolecules, Vol 12, Iss 2, p 325 (2022)
Pantothenate kinase-associated neurodegeneration (PKAN) is a progressive neurodegenerative disease caused by mutations in the pantothenate kinase 2 (PANK2) gene and associated with iron deposition in basal ganglia. Pantothenate kinase isoforms cataly
Externí odkaz:
https://doaj.org/article/fb0ce65519a141a1b76b5b107c1167a7
Publikováno v:
Polymers, Vol 11, Iss 5, p 926 (2019)
In numerous industrial applications, the microstructure of materials is critical for performance. However, finite element models tend to average out the microstructure. Hence, finite element simulations are often unsuitable for optimisation of the mi
Externí odkaz:
https://doaj.org/article/4ed1850774114c57ad261e09807565b7