Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ernst UR"'
Autor:
István Gyertyán, Jana Lubec, Alíz Judit Ernyey, Christopher Gerner, Ferenc Kassai, Predrag Kalaba, Kata Kozma, Iva Cobankovic, Gábor Brenner, Judith Wackerlig, Eva Franschitz, Ernst Urban, Thierry Langer, Jovana Malikovic, Gert Lubec
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract The lack of novel cognitive enhancer drugs in the clinic highlights the prediction problems of animal assays. The objective of the current study was to test a putative cognitive enhancer in a rodent cognitive test system with improved transl
Externí odkaz:
https://doaj.org/article/8de4d2688112472988785def180b9487
Autor:
Predrag Kalaba, Katharina Pacher, Philip John Neill, Vladimir Dragacevic, Martin Zehl, Judith Wackerlig, Michael Kirchhofer, Simone B. Sartori, Hubert Gstach, Shima Kouhnavardi, Anna Fabisikova, Matthias Pillwein, Francisco Monje-Quiroga, Karl Ebner, Alexander Prado-Roller, Nicolas Singewald, Ernst Urban, Thierry Langer, Christian Pifl, Jana Lubec, Johann Jakob Leban, Gert Lubec
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1415 (2023)
The high structural similarity, especially in transmembrane regions, of dopamine, norepinephrine, and serotonin transporters, as well as the lack of all crystal structures of human isoforms, make the specific targeting of individual transporters rath
Externí odkaz:
https://doaj.org/article/206825143bfe4497bebe4460b140ad5d
Autor:
Martina Oberhofer, Judith Wackerlig, Martin Zehl, Havva Büyük, Jia Jian Cao, Alexander Prado-Roller, Ernst Urban, Sergey B. Zotchev
Publikováno v:
ACS Omega, Vol 6, Iss 3, Pp 2184-2191 (2021)
Externí odkaz:
https://doaj.org/article/c165f01d9d6a47cb8655d63520cdb9a6
Autor:
Jana Lubec, Ahmed M. Hussein, Predrag Kalaba, Daniel Daba Feyissa, Edgar Arias-Sandoval, Anita Cybulska-Klosowicz, Mekite Bezu, Tamara Stojanovic, Volker Korz, Jovana Malikovic, Nilima Y. Aher, Martin Zehl, Vladimir Dragacevic, Johann Jakob Leban, Claudia Sagheddu, Judith Wackerlig, Marco Pistis, Merce Correa, Thierry Langer, Ernst Urban, Harald Höger, Gert Lubec
Publikováno v:
Biomolecules, Vol 13, Iss 3, p 467 (2023)
The worldwide increase in cognitive decline, both in aging and with psychiatric disorders, warrants a search for pharmacological treatment. Although dopaminergic treatment approaches represent a major step forward, current dopamine transporter (DAT)
Externí odkaz:
https://doaj.org/article/31e9c20c5680455db70326abd3c16764
Autor:
Alexander Taschauer, Wolfram Polzer, Fatih Alioglu, Magdalena Billerhart, Simon Decker, Theresa Kittelmann, Emanuela Geppl, Salma Elmenofi, Martin Zehl, Ernst Urban, Haider Sami, Manfred Ogris
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 774-786 (2019)
Peptide ligands can enhance delivery of nucleic acid-loaded nanoparticles to tumors by promoting their cell binding and internalization. Lung tumor lesions accessible from the alveolar side can be transfected, in principle, using gene vectors deliver
Externí odkaz:
https://doaj.org/article/e8100c4dc9b34814ac336f1a1a444687
Autor:
Shima Kouhnavardi, Alev Ecevitoglu, Vladimir Dragačević, Fabrizio Sanna, Edgar Arias-Sandoval, Predrag Kalaba, Michael Kirchhofer, Jana Lubec, Marco Niello, Marion Holy, Martin Zehl, Matthias Pillwein, Judith Wackerlig, Rita Murau, Andrea Mohrmann, Kathryn R. Beard, Harald H. Sitte, Ernst Urban, Claudia Sagheddu, Marco Pistis, Roberto Plasenzotti, John D. Salamone, Thierry Langer, Gert Lubec, Francisco J. Monje
Publikováno v:
Biomolecules, Vol 12, Iss 7, p 881 (2022)
Dopamine (DA), the most abundant human brain catecholaminergic neurotransmitter, modulates key behavioral and neurological processes in young and senescent brains, including motricity, sleep, attention, emotion, learning and memory, and social and re
Externí odkaz:
https://doaj.org/article/ea4993ee98834d4a80993681061f26a1
Autor:
Jonas Kilian, Marlon Millard, Marius Ozenil, Dominik Krause, Khadija Ghaderi, Wolfgang Holzer, Ernst Urban, Helmut Spreitzer, Wolfgang Wadsak, Marcus Hacker, Thierry Langer, Verena Pichler
Publikováno v:
Molecules, Vol 27, Iss 10, p 3173 (2022)
The muscarinic acetylcholine receptor family is a highly sought-after target in drug and molecular imaging discovery efforts aimed at neurological disorders. Hampered by the structural similarity of the five subtypes’ orthosteric binding pockets, t
Externí odkaz:
https://doaj.org/article/d52eff788f3b4aaf997cff8fa33f468d
Autor:
Jaime Felipe Guerrero-Garzón, Eva Madland, Martin Zehl, Madhurendra Singh, Shiva Rezaei, Finn L. Aachmann, Gaston Courtade, Ernst Urban, Christian Rückert, Tobias Busche, Jörn Kalinowski, Yan-Ru Cao, Yi Jiang, Cheng-lin Jiang, Galina Selivanova, Sergey B. Zotchev
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101785- (2020)
Summary: Heterologous expression of a biosynthesis gene cluster from Amycolatopsis sp. resulted in the discovery of two unique class IV lasso peptides, felipeptins A1 and A2. A mixture of felipeptins stimulated proliferation of cancer cells, while ha
Externí odkaz:
https://doaj.org/article/ca744bd661c34f49bb4b3e02ca36fe13
Autor:
Judith Wackerlig, Harald C. Köfeler, Volker Korz, Ahmed M. Hussein, Daniel D. Feyissa, Harald Höger, Ernst Urban, Thierry Langer, Gert Lubec, Jana Lubec
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Lipids play a major role for several brain functions, including cognition and memory. There is a series of work on individual lipids showing involvement in memory mechanisms, a concise lipidome was not reported so far. Moreover, there is no evidence
Externí odkaz:
https://doaj.org/article/8ca204f0b91048ea9dedfa9d37913337
Publikováno v:
Viruses, Vol 13, Iss 7, p 1307 (2021)
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that has re-emerged in recent decades, causing large-scale epidemics in many parts of the world. CHIKV infection leads to a febrile disease known as chikungunya fever (CHIKF), which is ch
Externí odkaz:
https://doaj.org/article/1b60357e2c104414bb02bb758e363f75