Zobrazeno 1 - 10 of 64 pro vyhledávání: '"Ernst Kupfer"'
1
Travessia do Sertão
Autor: Willi Bolle, Eckhard Ernst Kupfer
Publikováno v: Revista do Instituto de Estudos Brasileiros. :19-46
Por ocasião do bicentenário da viagem dos naturalistas alemães Spix e Martius pelo Brasil (1817-1820), dois pesquisadores e dois cineastas refizeram, em julho de 2018, um trecho daquela expedição: a travessia do sertão de Minas Gerais até a fr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e040ec33f939d64d8276c704a7bbf6a
https://doi.org/10.11606/issn.2316-901x.v0i72p19-46
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4
Biosynthetic Origin of a Branched Chain Analogue of the Lipase Inhibitor, Lipstatin
Autor: Adelbert Bacher, Wolfgang Weber, Ernst Kupfer, Peter Stohler, Wolfgang Eisenreich
Publikováno v: Journal of Medicinal Chemistry. 46:4209-4212
The lipophilic beta-lactone, lipstatin, inhibits pancreatic lipase and has been shown earlier to be biosynthesized by Claisen condensation of two fatty acid moieties. We present data from incorporation experiments with [U-13C6]leucine showing that a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3800a8626a195a664e199d1ded08dcef
https://doi.org/10.1021/jm030780x
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5
Biosynthesis of Lipstatin. Incorporation of Multiply Deuterium-Labeled (5Z,8Z)-Tetradeca-5,8-dienoic Acid and Octanoic Acid
Autor: Hans G. Leuenberger, Markus Goese, Peter Stohler, Ernst Kupfer, Wolfgang Eisenreich, Wolfgang A. Weber, Adelbert Bacher
Publikováno v: The Journal of Organic Chemistry. 66:4673-4678
Fermentation experiments with Streptomyces toxytricini were performed using (5Z,8Z)-[10,11,12,12-(2)H]tetradeca-5,8-dienoic acid or a mixture of [2,2-(2)H(2)]- and [8,8,8-(2)H(3)]octanoic acid as supplements. (2)H NMR and mass spectroscopy confirmed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a04b5d7152a55d1bf5ea65b6f56de18a
https://doi.org/10.1021/jo010230b
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6
Tracer Studies with Crude U-13C-Lipid Mixtures
Autor: Wolfgang Weber, Ernst Kupfer, Adelbert Bacher, Wolfgang Eisenreich
Publikováno v: Journal of Biological Chemistry. 272:867-874
The biosynthesis of the pancreatic lipase inhibitor lipstatin was investigated by fermentation experiments using cultures of Streptomyces toxytricini, which were supplied with soybean oil and a crude mixture of U-13C-lipids obtained from algal biomas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::673874a0bc5f3596ebedd60b54930f8b
https://doi.org/10.1074/jbc.272.2.867
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7
Large scale preparation of chiral building blocks for the P3 site of renin inhibitors
Autor: Wolfgang Wostl, Ernst Kupfer, Thomas Weisbrod, Beat Wirz, Stephan Doswald, Willi Walther, Heinz Stadler, Heinrich Estermann
Publikováno v: Bioorganic & Medicinal Chemistry. 2:403-410
Racemic ethyl 2-benzyl-3-(tert-butylsulfonyl)propionate (1) and racemic ethyl 2-benzyl-3-[[1-methyl-1-((morpholm-4-yl)carbonyl)ethyl]sulfonyl]p (3) were enantioselectively hydrolyzed by subtilisin Carlsberg generating the respective (S)-acids used as
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc3f92921a8150ea13f010f1824cb3c
https://doi.org/10.1016/0968-0896(94)80007-3
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8
Anantin-A peptide antagonist of the atrial natriuretic factor(ANF). I. Producing organism, fermentation, isolation and biological activity
Autor: Ernst Karl Weibel, Ernst Kupfer, Erich Hochuli, Walter Fischli, Wolfgang Weber
Publikováno v: The Journal of Antibiotics. 44:164-171
Anantin, a peptide binding to the receptor of the atrial natriuretic factor (ANF) was isolated from a strain of Streptomyces coerulescens. The molecule consists of 17 natural L-amino acids which form a peptidic ring system. It has a MW of 1,871.0. Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafe986d76cfceefdb0dd4baf7db90bc
https://doi.org/10.7164/antibiotics.44.164
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10
Biosynthetic precursors of the lipase inhibitor lipstatin
Autor: Wolfgang Eisenreich, Christoph A. Schuhr, Ernst Kupfer, Adelbert Bacher, Peter Stohler, Markus Goese, Wolfgang A. Weber
Publikováno v: The Journal of organic chemistry. 67(7)
Three putative intermediates in the biosynthesis of the lipase inhibitor lipstatin were synthesized in stable isotope-labeled form and were added to fermentation cultures of Streptomyces toxytricini. Biosynthetic lipstatin was isolated and analyzed b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2e963c986ec9c35e54a4884025b8b5
https://pubmed.ncbi.nlm.nih.gov/11925237
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