Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Ernst Küsters"'
Publikováno v:
Molecules, Vol 26, Iss 21, p 6508 (2021)
The adenosine monophosphate activated protein kinase (AMPK) is critical in the regulation of important cellular functions such as lipid, glucose, and protein metabolism; mitochondrial biogenesis and autophagy; and cellular growth. In many diseases—
Externí odkaz:
https://doaj.org/article/d5c06952b0134553af2176989661a101
Autor:
Herbert Mühle, Joachim Nozulak, Jacques Cercus, Ernst Küsters, Ulrich Beutler, Gerhard Penn, Werner Zaugg
Publikováno v:
CHIMIA, Vol 50, Iss 5 (1996)
cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]naphthyridine (rac-4) (SDZ SER-082) is a selective and potent 5-HT2C/2B receptor antagonist, exerting weak affinity towards the 5-HT2A receptor site. The compound 4 was found to be a
Externí odkaz:
https://doaj.org/article/24902d95c9ae4a5a82a9b258e18f8a68
Publikováno v:
Drewe, Jürgen; Küsters, Ernst; Hammann, Felix; Kreuter, Matthias; Boss, Philipp; Schöning, Verena (2021). Modeling Structure-Activity Relationship of AMPK Activation. Molecules, 26(21) Molecular Diversity Preservation International MDPI 10.3390/molecules26216508
Molecules
Volume 26
Issue 21
Molecules, Vol 26, Iss 6508, p 6508 (2021)
Molecules
Volume 26
Issue 21
Molecules, Vol 26, Iss 6508, p 6508 (2021)
The adenosine monophosphate activated protein kinase (AMPK) is critical in the regulation of important cellular functions such as lipid, glucose, and protein metabolism
mitochondrial biogenesis and autophagy
and cellular growth. In many dis
mitochondrial biogenesis and autophagy
and cellular growth. In many dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c1e9d5bcb062b6a820d4bf8fd2d2b82
https://boris.unibe.ch/162450/1/2021-10-28_Drewe.pdf
https://boris.unibe.ch/162450/1/2021-10-28_Drewe.pdf
Publikováno v:
Journal of Physical Organic Chemistry. 21:264-270
The Diels-Alder reaction has been examd. in room temp. ionic liqs. with high molar concns. of Lewis acids under various conditions. A molar ratio of 10% catalyst gave a large increase in the selectivity and the yield of the reaction. The effect of ca
Publikováno v:
Advanced Synthesis & Catalysis. 349:1803-1807
Josiphos ligands bearing an imidazolium moiety show high efficiency and reusability for the rhodium-catalyzed enantioselective hydrogenation of methyl acetamidoacrylate (MAA) and dimethyl itaconate (DMI) in biphasic co-solvent/ionic liquid combinatio
Publikováno v:
Journal of Physical Organic Chemistry. 20:109-114
The effect of pressure on the Diels-Alder reaction was examined in room temperature ionic liquids, followed by high-pressure FT-IR spectroscopy using pressures up to 150 MPa. Pressure enhances the kinetic sensitivity of the reaction. The kinetic effe
Publikováno v:
Organic Process Research & Development. 7:904-912
Different synthetic routes to the enantiomerically pure octahydrobenzo[g]quinoline derivative JNZ092 were evaluated for their suitability to rapidly prepare a first clinical batch on a kilogram scale. On the basis of the experience of previous octahy
Publikováno v:
Organic Process Research & Development. 6:652-659
The compound (2R,3S)-N-4-((S)-2,2-Dimethyl-1-methylcarbamoyl-propyl)-N-1-hydroxy-2-hydroxymethyl-3-(4-methoxy-phenyl)succinamide (1; SDZ 242-484) shows antiinflammatory effects due to inhibition of matrix metalloproteases (MMP) and tumor necrosis fac
Publikováno v:
Journal of Chromatography A. 925:139-149
As the third part of our methodology studies on the application of centrifugal counter-current chromatography to the preparative separation of macrolide antibiotic analogues, we have investigated the effects of various parameters on the retention of
Publikováno v:
Organic Process Research & Development. 5:211-215
The process for a pilot plant synthesis and the purification of a semisynthetic ascomycin derivative (1, SDZ ASD732) showing interesting biological activities is described. Conditions for the key transformation, a base-induced cascade of rearrangemen