Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Ernst Jan Speel"'
Autor:
Emil Chteinberg, Julia Vogt, Julia Kolarova, Felix Bormann, Joost van den Oord, Ernst Jan Speel, Véronique Winnepenninckx, Anna Kordelia Kurz, Martin Zenke, Reiner Siebert, Axel zur Hausen
Publikováno v:
Epigenetics, Vol 15, Iss 12, Pp 1319-1324 (2020)
Merkel cell carcinoma (MCC) is a very rare, but highly aggressive skin cancer which occurs mainly in elderly patients. MCC cells show an expression pattern of three cell lineages: epithelial, neuroendocrine, and B-cell progenitor. This trilinear expr
Externí odkaz:
https://doaj.org/article/2d32c18c53b94996b47ca34144baa1d1
Publikováno v:
Cells, Vol 9, Iss 11, p 2527 (2020)
Head and neck squamous cell carcinoma (HNSCC) is characterized by a poor 5 year survival and varying response rates to both standard-of-care and new treatments. Despite advances in medicine and treatment methods, mortality rates have hardly decreased
Externí odkaz:
https://doaj.org/article/c77205f893174948b7bd175646f59a00
Autor:
Emil Chteinberg, Christopher Martin Sauer, Dorit Rennspiess, Lukas Beumers, Lisa Schiffelers, Jonathan Eben, Anke Haugg, Véronique Winnepenninckx, Anna Kordelia Kurz, Ernst-Jan Speel, Martin Zenke, Axel zur Hausen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 12, Pp 1227-1235 (2018)
Merkel cell carcinoma (MCC) is a highly aggressive non-melanoma skin cancer of the elderly which is associated with the Merkel cell polyomavirus (MCPyV). MCC reveals a trilinear differentiation characterized by neuroendocrine, epithelial and pre/pro
Externí odkaz:
https://doaj.org/article/3215900ab6d34022995c9826eba3f4c2
Autor:
Emil Chteinberg, Suzan Wetzels, Wouter Gerritsen, Lieve Temmerman, Joost van den Oord, Erik Biessen, Anna Kordelia Kurz, Véronique Winnepenninckx, Martin Zenke, Ernst-Jan Speel, Axel zur Hausen
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Background: Merkel cell carcinoma (MCC) is a highly malignant skin cancer. Despite major treatment improvements during the last decade, up to 50% of patients do not respond to therapy or develop recurrent disease. For these patients, alternative trea
Externí odkaz:
https://doaj.org/article/b16ae6b01d8a4a70ac0deccedf5a266c
Autor:
Roel M. M. Bogie, Chantal M. C. le Clercq, Quirinus J. M. Voorham, Martijn Cordes, Daoud Sie, Christian Rausch, Evert van den Broek, Sara D. J. de Vries, Nicole C. T. van Grieken, Robert G. Riedl, Prapto Sastrowijoto, Ernst-Jan Speel, Rein Vos, Bjorn Winkens, Manon van Engeland, Bauke Ylstra, Gerrit A. Meijer, Ad A. M. Masclee, Beatriz Carvalho
Publikováno v:
British Journal of Cancer, 126(6), 865-873. Nature Publishing Group
Br J Cancer
Bogie, R M M, le Clercq, C M C, Voorham, Q J M, Cordes, M, Sie, D, Rausch, C, van den Broek, E, de Vries, S D J, van Grieken, N C T, Riedl, R G, Sastrowijoto, P, Speel, E-J, Vos, R, Winkens, B, van Engeland, M, Ylstra, B, Meijer, G A, Masclee, A A M & Carvalho, B 2021, ' Molecular pathways in post-colonoscopy versus detected colorectal cancers : results from a nested case–control study ', British Journal of Cancer . https://doi.org/10.1038/s41416-021-01619-z
British Journal of Cancer. Nature Publishing Group
Br J Cancer
Bogie, R M M, le Clercq, C M C, Voorham, Q J M, Cordes, M, Sie, D, Rausch, C, van den Broek, E, de Vries, S D J, van Grieken, N C T, Riedl, R G, Sastrowijoto, P, Speel, E-J, Vos, R, Winkens, B, van Engeland, M, Ylstra, B, Meijer, G A, Masclee, A A M & Carvalho, B 2021, ' Molecular pathways in post-colonoscopy versus detected colorectal cancers : results from a nested case–control study ', British Journal of Cancer . https://doi.org/10.1038/s41416-021-01619-z
British Journal of Cancer. Nature Publishing Group
Background: Post-colonoscopy colorectal cancers (PCCRCs) pose challenges in clinical practice. PCCRCs occur due to a combination of procedural and biological causes. In a nested case–control study, we compared clinical and molecular features of PCC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfc8c6029457491fffd8faa508b902c
https://doi.org/10.1038/s41416-021-01619-z
https://doi.org/10.1038/s41416-021-01619-z
Autor:
Lisa M. Hillen, Dorit Rennspiess, Ernst-Jan Speel, Anke M. Haugg, Véronique Winnepenninckx, Axel zur Hausen
Publikováno v:
Frontiers in Microbiology, Vol 8 (2018)
Seborrheic keratosis (SK) is the most common benign cutaneous neoplasm. A subset shows increased p16 expression. Since SK shares several features with verruca vulgaris, e.g., increased p16 expression, human papillomaviruses (HPV) have been suggested
Externí odkaz:
https://doaj.org/article/9674c9aed32041e6bdbfe788b51a8e9e
Autor:
Talya L. Dayton, Nicolas Alcala, Laura Moonen, Lisanne den Hartigh, Lise Mangiante, Lisa Lap, Antonella F. M. Dost, Joep Beumer, Sonja Levy, Rachel S. van Leeuwaarde, Wenzel M. Hackeng, Kris Samsom, Catherine Voegele, Alexandra Sexton-Oates, Harry Begthel, Jeroen Korving, Lisa Hillen, Lodewijk A. A. Brosens, Sylvie Lantuejoul, Sridevi Jaksani, Niels F.M. Kok, Koen J. Hartemink, Houke M. Klomp, Inne H.M. Borel Rinkes, Anne-Marie Dingemans, Gerlof D. Valk, Menno R. Vriens, Wieneke Buikhuisen, José van den Berg, Margot Tesselaar, Jules Derks, Ernst Jan Speel, Matthieu Foll, Lynnette Fernández-Cuesta, Hans Clevers
SUMMARYNeuroendocrine neoplasms (NENs) comprise well-differentiated neuroendocrine tumors and poorly-differentiated carcinomas. Treatment options for patients with NENs are limited, in part due to lack of accurate models. To address this need we esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3bc40d9a79e2adf83c5f5eab03f44e6
https://doi.org/10.1101/2022.10.31.514549
https://doi.org/10.1101/2022.10.31.514549
Publikováno v:
Huisarts en wetenschap. 65:16-17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcd1fd6519b369046549a8ce7640b0d2
https://doi.org/10.1007/s12445-022-1535-6
https://doi.org/10.1007/s12445-022-1535-6
Autor:
Peggy Prickaerts, Hanneke E C Niessen, Vivian E H Dahlmans, Frank Spaapen, Juliette Salvaing, Jolien Vanhove, Claudia Geijselaers, Stefanie J J Bartels, Iris Partouns, Dietbert Neumann, Ernst-Jan Speel, Yoshihiro Takihara, Bradly G Wouters, Jan Willem Voncken
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0118840 (2015)
Although the MK3 gene was originally found deleted in some cancers, it is highly expressed in others. The relevance of MK3 for oncogenesis is currently not clear. We recently reported that MK3 controls ERK activity via a negative feedback mechanism.
Externí odkaz:
https://doaj.org/article/2d874df7269046bf983ee2083853aff5