Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Ernst Hempelmann"'
Autor:
Ernst Hempelmann
Publikováno v:
Acta Scientific Pharmaceutical Sciences. 5:73-81
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80b72e81e1a12b767447a42ebf3f031c
https://doi.org/10.31080/asps.2021.05.0748
https://doi.org/10.31080/asps.2021.05.0748
Publikováno v:
'ChemMedChem ', vol: 16, pages: 1515-1532 (2021)
Kapishnikov, S, Hempelmann, E, Elbaum, M, Als-Nielsen, J & Leiserowitz, L 2021, ' Malaria Pigment Crystals : The Achilles ' Heel of the Malaria Parasite ', ChemMedChem . https://doi.org/10.1002/cmdc.202000895
ChemMedChem 16(10), 1515-1532 (2021). doi:10.1002/cmdc.202000895
Chemmedchem
Kapishnikov, S, Hempelmann, E, Elbaum, M, Als-Nielsen, J & Leiserowitz, L 2021, ' Malaria Pigment Crystals : The Achilles ' Heel of the Malaria Parasite ', ChemMedChem . https://doi.org/10.1002/cmdc.202000895
ChemMedChem 16(10), 1515-1532 (2021). doi:10.1002/cmdc.202000895
Chemmedchem
ChemMedChem 16(10), 1515 - 1532 (2021). doi:10.1002/cmdc.202000895
The biogenic formation of hemozoin crystals, a crucial process in heme detoxification by the malaria parasite, is reviewed as an antimalarial drug target. We first focus on the i
The biogenic formation of hemozoin crystals, a crucial process in heme detoxification by the malaria parasite, is reviewed as an antimalarial drug target. We first focus on the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::feca32a1f6098ee9fed42bb0bcecd2e2
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57803
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57803
Publikováno v:
Biotechnic & Histochemistry. 86:7-35
The components of the blood stain, eosin and methylene blue, were introduced by Baeyer and Caro, respectively. Methylene blue was used primarily for detecting Mycobacterium tuberculosis until Ehrlich in 1880 mixed methylene blue with acid fuchsin to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be8ca53119e2473c74f054968baa9f4
https://doi.org/10.3109/10520295.2010.515490
https://doi.org/10.3109/10520295.2010.515490
Autor:
Ernst Hempelmann, Marcos A. Vannier-Santos, Marcus F. Oliveira, Stefan Kycia, Pedro L. Oliveira, Aaron J. Kosar, Diego Menezes, Ariel Gómez, Sergio T. Ferreira, D. Scott Bohle
Publikováno v:
FEBS Letters. 579:6010-6016
Hemozoin (Hz) is a heme crystal produced upon the digestion of hemoglobin (Hb) by blood-feeding organisms as a main mechanism of heme disposal. The structure of Hz consists of heme dimers bound by reciprocal iron-carboxylate interactions and stabiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::223f133785d0c3b03bcfba0241cce1d2
https://doi.org/10.1016/j.febslet.2005.09.035
https://doi.org/10.1016/j.febslet.2005.09.035
Publikováno v:
Trends in Parasitology. 19:23-26
The intraerythrocytic parasites of Plasmodium falciparum are surrounded by a parasitophorous vacuolar membrane (PVM) that plays an important role both in parasite nutrient acquisition and in the trafficking of parasite proteins to the host cell membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::056c8234484a1d87404349206e1b1740
https://doi.org/10.1016/s1471-4922(02)00011-9
https://doi.org/10.1016/s1471-4922(02)00011-9
Autor:
Kristine P Krafts, Ernst Hempelmann
Publikováno v:
Malaria Journal
For many centuries, scientists have debated the cause and best treatment of the disease now known as malaria. Two theories regarding malaria transmission – that of “bad air” and that of insect vectors – have been widely accepted at different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d295a0d6c61a6d825766a81f1679ee
https://doi.org/10.1186/1475-2875-12-232
https://doi.org/10.1186/1475-2875-12-232
Publikováno v:
Parasitology research. 111(1)
Malarial treatment is widely and readily available today. However, there was a time in the not-so-distant past when malaria was a deadly disease with no known cause or cure. In this article, we trace the origins of an antimalarial therapy from the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24de45947f776b6778307744a6123a19
https://pubmed.ncbi.nlm.nih.gov/22411634
https://pubmed.ncbi.nlm.nih.gov/22411634
Autor:
Ernst Hempelmann, Helder M. Marques
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 32:25-30
The biochemical pathway for the production of malaria pigment (haemozoin) forms a fundamental difference between host and parasite and is likely to be an important drug target. A simple method for the isolation of malaria pigment is described. The re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78574040a5af356a6c22101b329b7a5e
https://doi.org/10.1016/1056-8719(94)90013-2
https://doi.org/10.1016/1056-8719(94)90013-2
Methylene blue was synthesized by Caro in 1876 at BASF, a chemical company. Six years later, Koch employed methylene blue when he discovered the tubercle bacillus. In 1880, Ehrlich described what he termed "neutral" dyes: mixtures of acidic and basic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab8e801d64250eb5853b19a6d0d1a1e
https://ruj.uj.edu.pl/xmlui/handle/item/69796
https://ruj.uj.edu.pl/xmlui/handle/item/69796
Publikováno v:
Pharmazie in unserer Zeit. 38(6)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::469d4a8a7febef6a69fff8f042ea5030
https://pubmed.ncbi.nlm.nih.gov/19862717
https://pubmed.ncbi.nlm.nih.gov/19862717