Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ernst Böhnlein"'
Autor:
Micha Rosenkranz, Kristin Fürle, Julia Hibbert, Anne Ulmer, Arin Ali, Thomas Giese, Antje Blank, Walter E. Haefeli, Ernst Böhnlein, Michael Lanzer, Richard Thomson-Luque
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-17 (2023)
Abstract Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver stages and the disease-causing blood stages of the human malaria parasite Plasmodium falciparum. While substantial progress has been made towards l
Externí odkaz:
https://doaj.org/article/8a2370c07fb045ea9013c090061948cc
Autor:
Gerd Mikus, Ernst Böhnlein, Michael Lanzer, Anja Jäschke, Walter E. Haefeli, Kirsten Heiss, Kristin Fürle, Antje Blank, Hermann Bujard, Johannes Hüsing, Darrick Carter, Monika Lehmann, Thomas Giese
Publikováno v:
npj Vaccines, Vol 5, Iss 1, Pp 1-15 (2020)
A vaccine remains a priority in the global fight against malaria. Here, we report on a single-center, randomized, double-blind, placebo and adjuvant-controlled, dose escalation phase 1a safety and immunogenicity clinical trial of full-length Plasmodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f773f58de8d6fa913003adbdb95d77
https://doi.org/10.1038/s41541-020-0160-2
https://doi.org/10.1038/s41541-020-0160-2
Autor:
Antje, Blank, Kristin, Fürle, Anja, Jäschke, Gerd, Mikus, Monika, Lehmann, Johannes, Hüsing, Kirsten, Heiss, Thomas, Giese, Darrick, Carter, Ernst, Böhnlein, Michael, Lanzer, Walter E, Haefeli, Hermann, Bujard
Publikováno v:
NPJ Vaccines
A vaccine remains a priority in the global fight against malaria. Here, we report on a single-center, randomized, double-blind, placebo and adjuvant-controlled, dose escalation phase 1a safety and immunogenicity clinical trial of full-length Plasmodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1bb90caa8155f5031f6b7fc9fa7a4296
https://pubmed.ncbi.nlm.nih.gov/32025341
https://pubmed.ncbi.nlm.nih.gov/32025341
Autor:
Ernst Böhnlein, Kyle Hendricks, Linda N. Liu, Gang Wang, Joseph D. Mosca, Uwe Junker, Keunmyoung Lee
Publikováno v:
STEM CELLS Translational Medicine. 2:362-375
Rheumatoid arthritis (RA) is a systemic autoimmune disease with unknown etiology where tumor necrosis factor-α (TNFα) plays a critical role. Etanercept, a recombinant fusion protein of human soluble tumor necrosis factor receptor II (hsTNFR) linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b2e94cfe7d17c29d0d5827056342b6b
https://doi.org/10.5966/sctm.2012-0135
https://doi.org/10.5966/sctm.2012-0135
Autor:
Uwe Junker, Ernst Böhnlein
Publikováno v:
Expert Opinion on Therapeutic Patents. 9:1491-1498
Gene therapy for rheumatoid arthritis (RA) is a relatively novel therapeutic concept. At present, two clinical trials are ongoing which evaluate the safety of ex vivo gene transfer into synoviocytes. However, it is anticipated that the number of clin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::986e120f9ec1ea03c550e8e8b57d2be8
https://doi.org/10.1517/13543776.9.11.1491
https://doi.org/10.1517/13543776.9.11.1491
Autor:
Uwe Junker, Carmen Barske, Creton Kalfoglou, Hideto Kaneshima, Gabor Veres, Heini Ilves, J Baker, Sonia Escaich, Ernst Böhnlein
Publikováno v:
Journal of Virology. 72:1894-1901
The antiviral activities of intracellularly expressed antisense RNAs complementary to the human immunodeficiency virus type 1 (HIV-1) pol , vif , and env genes and the 3′ long terminal repeat (LTR) sequence were evaluated in this comparative study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edbb00ec4aba49e8f6cf0b3b5684be3a
https://doi.org/10.1128/jvi.72.3.1894-1901.1998
https://doi.org/10.1128/jvi.72.3.1894-1901.1998
Publikováno v:
AIDS Research and Human Retroviruses. 13:1395-1402
Gene therapy for the treatment of human immunodeficiency virus type 1 (HIV-1) infection using intracellular immunization strategies is currently being tested in clinical trials. With the continuing development of potent antiretroviral drugs (e.g., re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1268acd58461fdd416eda0627a21546e
https://doi.org/10.1089/aid.1997.13.1395
https://doi.org/10.1089/aid.1997.13.1395
Autor:
Stephen J. Forman, Creton Kalfoglou, Irena Sniecinski, James J. Moon, Hideto Kaneshima, John A. Zaia, Ernst Böhnlein, Uwe Junker
Publikováno v:
Blood. 89:4299-4306
The potential of hematopoietic stem cells (HSCs) from human immunodeficiency virus type-1 (HIV-1)–infected individuals, eg, self-renewal and multilineage differentiative capacity, might be perturbed due to the underlying disease. In this study, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79859d7be579fc75499250c7cdc745c8
https://doi.org/10.1182/blood.v89.12.4299
https://doi.org/10.1182/blood.v89.12.4299
Publikováno v:
Gene. 171:203-208
Retroviral gene delivery systems for RNA polymerase II (RNA pol II)-based promoters have been developed and are widely used in gene transfer studies. In contrast, gene delivery systems with RNA pol III-based expression cassettes have not been studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dab947118744e22226225feb26a68d
https://doi.org/10.1016/0378-1119(96)00075-3
https://doi.org/10.1016/0378-1119(96)00075-3
Autor:
Ernst Böhnlein, Ivan Plavec, Sumesh Kaushal, Creton Kalfoglou, Joseph D. Mosca, Sonia Escaich
Publikováno v:
Human Gene Therapy. 6:625-634
Two clinical regimens have been proposed for gene therapies of acquired immunodeficiency syndrome (AIDS): (i) Genetic modification of differentiated peripheral mononuclear cells ex vivo and (ii) gene delivery into hematopoietic stem/progenitor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0de9007c177438fa3ed18f89ce699aa
https://doi.org/10.1089/hum.1995.6.5-625
https://doi.org/10.1089/hum.1995.6.5-625