Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Ernst A. Singer"'
Autor:
Ernst A. Singer, Christiane Druml
Publikováno v:
Clinical Pharmacology: Current Topics and Case Studies ISBN: 9783319273457
Physicians engaged in clinical research must address the challenge to determine whether a potential new intervention represents an advance over current methods, whether the new intervention would avoid harms currently incurred, whether it would save
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89d017234577b8f1967946b1b8df6c22
https://doi.org/10.1007/978-3-319-27347-1_5
https://doi.org/10.1007/978-3-319-27347-1_5
Autor:
Ernst A. Singer
Publikováno v:
Onkologie. 31:21-24
General Pharmacology consists of two fields of interest, pharmacodynamics and pharmacokinetics. The most important concept in pharmacodynamics is the dose-response relationship, which describes the dependence of the effect of a drug from its concentr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fe1d9ba615ba9154813ade6c1fe9b78
https://doi.org/10.1159/000113446
https://doi.org/10.1159/000113446
Autor:
Brigitta Bondy, Dietmar Winkler, Michael B. Fischer, Ernst A. Singer, Werner Brannath, Matthäus Willeit, Siegfried Kasper, Nicole Praschak-Rieder, N. Thierry, Harald H. Sitte, Peter Zill, Klaus G. Michalek
Publikováno v:
Neuropsychopharmacology. 33:1503-1513
Decreased synaptic serotonin during depressive episodes is a central element of the monoamine hypothesis of depression. The serotonin transporter (5-HTT, SERT) is a key molecule for the control of synaptic serotonin levels. Here we aimed to detect st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8edf8d788dfe90cb489b743b8fc7ce40
https://doi.org/10.1038/sj.npp.1301560
https://doi.org/10.1038/sj.npp.1301560
Autor:
Harald H. Sitte, Marion Holy, Stefan Boehm, Ernst A. Singer, Walter Sandtner, Petra Scholze, Birgit Hilber, Mario M. Dorostkar
Publikováno v:
Neuropharmacology. 49:811-819
The physiological function of neurotransmitter transporter proteins like the serotonin transporter (SERT) is reuptake of neurotransmitter that terminates synaptic serotoninergic transmission. SERT can operate in reverse direction and be induced by SE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df4c0d38ad45cb50f1088867cb38ff8
https://doi.org/10.1016/j.neuropharm.2005.08.008
https://doi.org/10.1016/j.neuropharm.2005.08.008
Publikováno v:
Scopus-Elsevier
Europe PubMed Central
Europe PubMed Central
This study explores the role of cyclic AMP in electrically evoked [3H]noradrenaline release and in the α2-adrenergic modulation of this release in chick sympathetic neurons. Along with an increase in stimulation-evoked tritium overflow, applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7d6ddd2e7988a844ea3e0d211b6ce55
https://doi.org/10.1046/j.1471-4159.1994.63010146.x
https://doi.org/10.1046/j.1471-4159.1994.63010146.x
Publikováno v:
British Journal of Pharmacology. 135:93-102
Bi-directional GABA-transport was studied by performing uptake and superfusion experiments in human embryonic kidney 293 cells stably expressing the rat GABA transporter rGAT-1. KM and Vmax values for [3H]-GABA uptake were 11.7±1.8 μM and 403±55 p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7ec5db6dd56518c0076ada11b05cb0c
https://doi.org/10.1038/sj.bjp.0704446
https://doi.org/10.1038/sj.bjp.0704446
Autor:
Michael Freissmuth, Oliver Kudlacek, Harald H. Sitte, Ernst A. Singer, Johannes A. Schmid, Petra Scholze
Publikováno v:
Journal of Biological Chemistry. 276:3805-3810
Recent biochemical studies indicate that the serotonin transporter can form oligomers. We investigated whether the human serotonin transporter (hSERT) can be visualized as an oligomer in the plasma membrane of intact cells. For this purpose, we gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b0b78d3421bcb5d90e68c15f89279f
https://doi.org/10.1074/jbc.m007357200
https://doi.org/10.1074/jbc.m007357200
Publikováno v:
Pure and Applied Chemistry. 72:1045-1050
Amphetamine analogues are able to induce signs of neurotoxicity in the brain. In order to understand this type of neurotoxicity, the interaction of amphetamine with its molecular targets must be elucidated. These molecular targets are plasmalemmal an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0686cebbc6a52fb119596ef6dff06790
https://doi.org/10.1351/pac200072061045
https://doi.org/10.1351/pac200072061045
Publikováno v:
Intensive Care Medicine. 35:613-615
Purpose This paper describes the experience of the Ethics Committee of the Medical University of Vienna, Austria, while managing the workload of clinical study applications.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfc8a0778679b7334acb4063158ebb69
https://doi.org/10.1007/s00134-008-1343-x
https://doi.org/10.1007/s00134-008-1343-x
Autor:
Ernst A. Singer
Publikováno v:
Onkologie. 31:64-66
In 1993 the European Medicines Agency (EMEA) for the registration of new medicinal products in Europe was founded. The agency started its work in 1995 and is supported by five scientific committees, the most important one being the Committee for Medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a31ae9a3aa15af82faba0b4cb4d8bad
https://doi.org/10.1159/000113448
https://doi.org/10.1159/000113448