Výsledky vyhledávání - "Ernna Hérida Domingues de Oliveira"

Dissertation/ Thesis

Vias de regulação da expressão gênica promíscua no timo envolve Aire e microRNAs

Autor: Ernna Hérida Domingues de Oliveira

Publikováno v: Biblioteca Digital de Teses e Dissertações da USPUniversidade de São PauloUSP.

O timo é um orgão linfóide primário, no qual ocorre a indução da tolerância imunológica central aos antígenos do próprio que são expressos pelos tecidos periféricos (PTAs). A medula tímica é formada por células tímicas medulares epite

Externí odkaz: http://www.teses.usp.br/teses/disponiveis/17/17135/tde-15052014-100817/

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O gene CCR5 e a mutação que confere proteção contra o vírus HIV

Autor: Ernna Hérida Domingues de Oliveira, Romário de Sousa Mascarenhas, Max Jordan Duarte, Natane de Araújo Miglioli

Publikováno v: Genética na Escola. 16:294-305

Uma das maiores descobertas clínicas e científicas a respeito da patogênese do HIV foi alcançada por meio do conhecimento de que o gene CCR5, expresso em linfócitos T CD4 (célula CD4) codifica uma proteína de superfície que age como correcept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee2222741960bc268a38c70a7e3e2457
https://doi.org/10.55838/1980-3540.ge.2021.377

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Aire

Autor: Ernna Hérida Domingues de Oliveira, Geraldo Aleixo Passos, Tiago Campos Pereira

Publikováno v: Genética na Escola. 15:226-231

O gene Aire (Autoimmune Regulator) foi descoberto na década de 1990, por meio de estudos de associação genótipo-fenótipo da doença autoimune humana APECED (poli endocrinopatia auto-imune tipo 1). A doença é desencadeada por mutações no gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::975bf040e1cfb149c5537ee012ebc516
https://doi.org/10.55838/1980-3540.ge.2020.338

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What Is the Transcriptome and How It Is Evaluated

Autor: Paula B. Donate, Catherine P. Nguyen, Amanda Freire Assis, Geraldo Aleixo Silva Passos, Ernna Hérida Domingues de Oliveira, Silvana Giuliatti

Publikováno v: Transcriptomics in Health and Disease ISBN: 9783030878207
Transcriptomics in Health and Disease ISBN: 9783319119847

The concept of the transcriptome revolves around the complete set of transcripts present in a given cell type, tissue or organ and encompasses both coding and non-coding RNA molecules, although we often assume that it consists only of messenger RNAs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c521f1d56b2c3ba70f48ecd4e0303404
https://doi.org/10.1007/978-3-030-87821-4_1

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Adhesion between medullary thymic epithelial cells and thymocytes is regulated by miR-181b-5p and miR-30b*

Autor: Nicole Pezzi, Larissa Cotrim-Sousa, Amanda Freire-Assis, Ernna Hérida Domingues de Oliveira, Geraldo Aleixo Silva Passos, Pedro Paranhos Tanaka

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

In this work, we demonstrate that adhesion between medullary thymic epithelial cells (mTECs) and thymocytes is controlled by miRNAs. Adhesion between mTECs and developing thymocytes is essential for triggering negative selection (NS) of autoreactive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aac5a70f62bfba980e7d6e91c32345b
https://doi.org/10.1016/j.molimm.2019.09.010

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A Reação em Cadeia da Polimerase (PCR)

Autor: Ernna Hérida Domingues de Oliveira, Tiago Campos Pereira

Publikováno v: Genética na Escola. 14:88-97

A Reação em Cadeia da Polimerase (PCR) é uma técnica que permite gerar, em um tubo de ensaio, bilhões de cópias de uma determinada sequência de DNA de interesse, de maneira rápida, prática e barata. Baseada no processo natural de duplicaçã

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d6edf2c985b5f6e0d323b737492daf7
https://doi.org/10.55838/1980-3540.ge.2019.318

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miR-155 exerts posttranscriptional control of autoimmune regulator (Aire) and tissue-restricted antigen genes in medullary thymic epithelial cells

Autor: Amanda Freire Assis, Karina Fittipaldi Bombonato-Prado, Max Jordan Duarte, Pedro Paranhos Tanaka, Geraldo Aleixo Silva Passos, Ernna Hérida Domingues de Oliveira, Vieira-Machado Mc

Publikováno v: BMC genomics. 23(1)

Background The autoimmune regulator (Aire) gene is critical for the appropriate establishment of central immune tolerance. As one of the main controllers of promiscuous gene expression in the thymus, Aire promotes the expression of thousands of downs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f76e261334b5514fba0f1e15d6fb15
https://pubmed.ncbi.nlm.nih.gov/35643451

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A Crispr-Cas9 System Designed to Introduce Point Mutations into the Human ACE2 Gene to Weaken the Interaction of the ACE2 Receptor with the SARS-CoV-2 S Protein

Autor: Geraldo Aleixo Silva Passos, Mayara Cristina Vieira Machado, Pedro Paranhos Tanaka, Leticia Agrelli de Brito, Jadson C. Santos, Leticia Oliveira, Natane Miglioli, A. F. Assis, Ernna Hérida Domingues de Oliveira, Vitor Ribeiro, Max Jordan Duarte, Alex Souza, Eduardo Antônio Donadi, Romario S. Mascarenhas, Ana Carolina Monteleone-Cassiano

The human angiotensin-converting enzyme 2 (ACE2) has a crucial role on blood pressure control; however, ACE2 is also the primary SARS-CoV-2 (S domain) virus receptor. Inhibiting or even reducing the expression of the native ACE2 might diminish the vi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a7ab06dfcf645534a8d953e5f6d718af
https://doi.org/10.20944/preprints202005.0134.v1

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The Thymus as a Mirror of the Body’s Gene Expression

Autor: Pedro Paranhos Tanaka, Ernna Hérida Domingues de Oliveira, Romario S. Mascarenhas, Amanda Freire Assis, Eduardo Antônio Donadi, Ana Carolina Monteleone-Cassiano, Geraldo Aleixo Silva Passos, Max Jordan Duarte, Mayara Cristina Vieira Machado, Adriana Borges Genari

Publikováno v: Thymus Transcriptome and Cell Biology ISBN: 9783030120399

The thymus is a complex organ formed by different cell types that establish close interaction. The role played by the thymic stroma is very intriguing, since it is not only a connective tissue or a support structure. The stromal thymic epithelial cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d9e2ac7e7e9779f077d941ee926653f
https://doi.org/10.1007/978-3-030-12040-5_9

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Aire Downregulation Is Associated with Changes in the Posttranscriptional Control of Peripheral Tissue Antigens in Medullary Thymic Epithelial Cells

Autor: Geraldo Aleixo Silva Passos, Ernna Hérida Domingues de Oliveira, Cristhianna V.A. Collares, Ana Carolina Vasques Freitas, Eduardo Antônio Donadi, Claudia Macedo, Elza Tiemi Sakamoto-Hojo, Paula B. Donate

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology

Autoimmune regulator (Aire) is a transcriptional regulator of peripheral tissue antigens (PTAs) and microRNAs (miRNAs) in medullary thymic epithelial cells (mTECs). In this study, we tested the hypothesis that Aire also played a role as an upstream p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::716a1d2ea680de2e84fc28ea16ab8b12
https://doi.org/10.3389/fimmu.2016.00526

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