Výsledky vyhledávání

BRMS1 in gliomas – an expression analysis

Autor: Feldheim, JJ, Feldheim, J, Keßler, AF, Glas, M, Ernestus, RI, Monoranu, CM, Löhr, M, Hagemann, C

Publikováno v: 73. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Griechischen Gesellschaft für Neurochirurgie; 20220529-20220601; Köln; DOCV174 /20220525/

Objective: Glioblastoma multiforme (GBM) is the most common malignant primary tumor of the central nervous system. Up to this day, patients diagnosed with GBM face an unfavorable prognosis, even with the intense standard treatment consisting of surgi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ecd03af01e2be65e17e5be11268d3c8

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Protocol for gradual weaning from external ventricular drainage with repetitive lumbar punctures in patients with posthemorrhagic hydrocephalus from aneurysmal subarachnoid haemorrhage – a single-centre study

Autor: Cattaneo, A, Geske, C, Semmler, F, Beez, A, Weiland, J, Lamllari, K, Dufner, V, Stetter, C, Ernestus, RI, Kunze, E, Wipplinger, C

Objective: Chronic posthemorrhagic hydrocephalus is a common condition in patients with saneurysmal subarachnoid hemorrhage (aSAH). Treatment with external ventricular drainage (EVD) is a standard life-saving treatment in the acute phase. There are c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eaa73892dce8aba1db73b32120ce67b

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Licochalcone A – an ADAM9 inhibitor for vestibular schwannoma therapy

Autor: Flock, K, Matthies, C, Ernestus, RI, Löhr, M, Hagemann, C, Breun, M

Objective: Recently, we described a disintegrin and metalloproteinase 9 (ADAM9) overexpression by Schwann cells of vestibular schwannoma (VS) and suggested that it might be a marker for VS tumor growth and invasiveness. Consequently, we analyzed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b1deaf06146c58750d68b25b045cf6a

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Tumour Treating Fields (TTFields) promotes Rho kinase-dependent phosphorylation of the tight junction protein claudin-5

Autor: Salvador, E, Keßler, AF, Burek, M, Tempel Brami, C, Voloshin-Sela, T, Volodin, A, Adel, Z, Giladi, M, Ernestus, RI, Löhr, M, Förster, C, Hagemann, C

Objective: Tumor Treating Fields (TTFields) are alternating electrical fields that are approved and effective for glioblastoma therapy with a frequency of 200 kHz. At a frequency of 100 kHz, we have previously shown that TTFields can transiently open

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Assessment of functional outcome after resection of eloquently located lower grade gliomas based on the LoG-Glio registry

Objective: Lower grade gliomas (LGG) often infiltrate eloquent regions, so that neurological impairment and oncological benefit by surgery have to be balanced. Aim of our study was to assess rate of permanent deficits and its risk factors in eloquent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3682e1a1c5304b9e5e83cb9dbabedc

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Life threatening meningiomas in neurofibromatosis type 2 – an indication for peptide receptor radionuclide therapy?

Autor: Matthies, C, Breun, M, Kertels, O, Hänscheid, H, Hartrampf, P, Ernestus, RI, Buck, AK, Lapa, C

Publikováno v: 72. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Polnischen Gesellschaft für Neurochirurgie; 20210606-20210609; sine loco [digital]; DOCV262 /20210604/

Objective: Multifocal progressive meningiomas in Neurofibromatosis type 2 (NF2) may become life threatening by increased intracranial pressure and severe neurological deficits, especially in reduced state from chronic NF disease. This analysis was de

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Intraoperative-moulded- vs. CAD-CAM-cranioplasty after decompressive craniectomy – a retrospective single-centre analysis of 258 cases with regard to perioperative modalities as well as short- and long-term complication rates and aesthetic results

Autor: Hädrich, D, Westermaier, T, Cattaneo, A, Keßler, AF, Ernestus, RI, Pakos, P, Lilla, N

Objective: Cranioplasty (CP) after decompressive craniectomy (DC) restores the functionality and aesthetic of the patients cranial vault. Although it is a routine procedure, high complication rates have been described, partly related to the type of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf54376300a4e68c6af0b7aa212da80

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Characterisation of heterogeneous antigen-expression pattern comparing glioblastoma cell lines, patient-derived cells and patients’ glioblastoma tissue

Autor: Dufner, V, Schulz, E, Monoranu, C, Hudecek, M, Hagemann, C, Ernestus, RI, Löhr, M, Nerreter, T

Objective: Immunotherapeutic treatment of glioblastoma (GBM) is one of the most challenging tasks due to heterogeneous surface expression of target antigens. It has previously been reported that GBM cell lines (GCL), patient-derived cells (PDC) and p

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Neuropathy in neurofibromatosis types 1, 2 and 3 – a study protocol to address a neglected feature

Autor: Matthies, C, Rampeltshammer, E, Weiland, J, Breun, M, Ernestus, RI, Pham, M, Üçeyler, N

Objective: Neurofibromatosis (NF) is associated with multiple nerve tumors mostly presenting at young or even adolescent age. Neuropathy is a further frequent symptom in NF and may be related to schwannoma / neurofibroma formation or may occur indepe

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Contemporary management of diffuse low-grade glioma from six certified neuro-oncological centres – prospective data from the LoG-Glio registry

Autor: Coburger, J, Nadji-Ohl, M, von der Brelie, C, Rückriegel, S, Roder, C, Faust, K, Sachs, D, Grüninger, S, Löhr, M, Vajkoczy, P, Tatagiba, M, Ernestus, RI, Rohde, V, Ganslandt, O, Wirtz, CR, Pala, A

Publikováno v: 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie; 20200621-20200624; sine loco [digital]; DOCV251 /20200626/

Objective: In recent years, some level of consensus for management of diffuse astrocytoma and oligodendroglioma was reached. Aim of the present study was to assess the current management of these lesions based on data from the LoG-Glio registry. Meth

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