Development of the Late-Phase Manufacturing Process of ZPL389: Control of Process Impurities by Enhanced Process Knowledge

Autor: Christine Waldraff, Ernesto Santandrea, Gilles Gerber, Maël Moreau, Pascal Beney

Publikováno v: Organic Process Research & Development. 25:1190-1205

The development of the late-phase manufacturing process of the drug candidate ZPL389 and the strategies for the control of impurities are outlined in detail. Selective salt formation at several sta...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ceb9b2eecf5da3353c0cd7531429585
https://doi.org/10.1021/acs.oprd.1c00077

Stereoselective Prostereogenic 3-Oxo Ester Reduction Mediated by a Novel Yeast Alcohol Dehydrogenase Derived fromKluyveromyces marxianus CBS 6556

Autor: Maria Grazia Perrone, Antonio Scilimati, Christoph Syldatk, Ernesto Santandrea

Publikováno v: Advanced Synthesis & Catalysis. 349:1111-1118

A yeast alcohol dehydrogenase (ADH) has been purified up to a purification factor value of 21,731-fold from Kluyveromyces marxianus CBS 6556. The purification procedure consisted of two chromatographic steps (DEAE-anion exchange and affinity chromato

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01eb02d44196b69ef22ea3878130e068
https://doi.org/10.1002/adsc.200600379

Screening yeasts for the stereoselective reduction of oxoester clofibrate analogues

Autor: Antonio Scilimati, Vincenzo Tortorella, Ernesto Santandrea, Christoph Syldatk, Maria Grazia Perrone

Publikováno v: Tetrahedron: Asymmetry. 16:1473-1477

Reduction of oxoesters 1b – d and 1f , g in the presence of different yeast strains ( Saccharomyces cerevisiae DSM 11285, S. cerevisiae CBS 7336, Cryptococcus curvatus ATCC 20509, Candida bombicola ATCC 22214, Trigonopsis variabilis DSM 70714, Kluy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a20af0f13e8351d59aabecce4c5d3d49
https://doi.org/10.1016/j.tetasy.2005.02.010

Diastereo- and enantioselective bioreduction of ethyl 2-(4-chlorophenoxy)-3-oxobutanoate clofibrate analogues by Kluyveromyces marxianus and other whole cell biocatalysts

Autor: Ernesto Santandrea, Christoph Syldatk, Valerio Bertolasi, Francesco Capitelli, Vincenzo Tortorella, Maria Grazia Perrone, Antonio Scilimati

Publikováno v: Tetrahedron: asymmetry
15 (2004): 3511–3517. doi:10.1016/j.tetasy.2004.08.028
info:cnr-pdr/source/autori:Perrone M.G. 1, Santandrea E. 1, Scilimati A. 1, Syldatk C. 2, Tortorella V. 1, Capitelli F. 3, Bertolasi V. 4/titolo:Diastero-and enantioselective bioreduction of ethyl 2-(4-chlophenoxy)-3-oxobutanoate clofibrate analogues by Kluyveromyces marxianus and other whole cell biocatalysts/doi:10.1016%2Fj.tetasy.2004.08.028/rivista:Tetrahedron: asymmetry (Print)/anno:2004/pagina_da:3511/pagina_a:3517/intervallo_pagine:3511–3517/volume:15

Growing and resting cells of several yeasts, which catalyze the hydride transfer to a carbonyl, were screened and used in conditions to find out the suitable methodology to prepare clofibrate analogues. Clofibrate is an antilipidemic drug. In particu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28d21c80ec6d49c83f4325d5dc264fe
https://doi.org/10.1016/j.tetasy.2004.08.028

Synthesis and Biological Evaluation of New Clofibrate Analogues as Potential PPARα Agonists

Autor: Anna Floriana Sciarroni, Maria Grazia Perrone, Antonio Scilimati, Natalina Dell'uomo, Ferdinando Maria Milazzo, Fabio Giannessi, Vincenzo Tortorella, Ernesto Santandrea

Publikováno v: ChemInform. 36

Clofibrate is a lipid-profile modifying agent belonging to the fibrate class of drugs. Fibrates are known to exhibit their beneficial effects by activating peroxisome proliferator-activated receptor-α (PPARα) and used in the treatment of dyslipidem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0d32abf382104aac18db6e571e4bc64
https://doi.org/10.1002/chin.200525074