Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Ernesto S. Nakayasu"'
Autor:
Soumyadeep Sarkar, Cailin Deiter, Jennifer E. Kyle, Michelle A. Guney, Dylan Sarbaugh, Ruichuan Yin, Xiangtang Li, Yi Cui, Mireia Ramos-Rodriguez, Carrie D. Nicora, Farooq Syed, Jonas Juan-Mateu, Charanya Muralidharan, Lorenzo Pasquali, Carmella Evans-Molina, Decio L. Eizirik, Bobbie-Jo M. Webb-Robertson, Kristin Burnum-Johnson, Galya Orr, Julia Laskin, Thomas O. Metz, Raghavendra G. Mirmira, Lori Sussel, Charles Ansong, Ernesto S. Nakayasu
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Lipids are regulators of insulitis and β-cell death in type 1 diabetes development, but the underlying mechanisms are poorly understood. Here, we investigated how the islet lipid composition and downstream signaling regulate β-c
Externí odkaz:
https://doaj.org/article/6b57b4f4064a4390ae8f0840effa40ac
Autor:
Elisa Gonçalves Medeiros, Michele Ramos Valente, Leandro Honorato, Marina da Silva Ferreira, Susana Ruiz Mendoza, Diego de Souza Gonçalves, Lucas Martins Alcântara, Kamilla Xavier Gomes, Marcia Ribeiro Pinto, Ernesto S. Nakayasu, Geremy Clair, Isadora Filipaki Munhoz da Rocha, Flavia C. G. dos Reis, Marcio L. Rodrigues, Lysangela R. Alves, Leonardo Nimrichter, Arturo Casadevall, Allan Jefferson Guimarães
Publikováno v:
mSystems, Vol 9, Iss 6 (2024)
ABSTRACT We conducted a comprehensive comparative analysis of extracellular vesicles (EVs) from two Acanthamoeba castellanii strains, Neff (environmental) and T4 (clinical). Morphological analysis via transmission electron microscopy revealed slightl
Externí odkaz:
https://doaj.org/article/6d88a4b62eab476089b31eb9bf95d733
Autor:
Milene C. Vallejo, Soumyadeep Sarkar, Emily C. Elliott, Hayden R. Henry, Samantha M. Powell, Ivo Diaz Ludovico, Youngki You, Fei Huang, Samuel H. Payne, Sasanka Ramanadham, Emily K. Sims, Thomas O. Metz, Raghavendra G. Mirmira, Ernesto S. Nakayasu
Publikováno v:
Scientific Data, Vol 10, Iss 1, Pp 1-14 (2023)
Abstract Extracellular vesicles play major roles in cell-to-cell communication and are excellent biomarker candidates. However, studying plasma extracellular vesicles is challenging due to contaminants. Here, we performed a proteomics meta-analysis o
Externí odkaz:
https://doaj.org/article/a7d72d2c446c44ff926f2c19bd0e61eb
Autor:
Bobbie-Jo M. Webb-Robertson, Ernesto S. Nakayasu, Fran Dong, Kathy C. Waugh, Javier E. Flores, Lisa M. Bramer, Athena A. Schepmoes, Yuqian Gao, Thomas L. Fillmore, Suna Onengut-Gumuscu, Ashley Frazer-Abel, Stephen S. Rich, V. Michael Holers, Thomas O. Metz, Marian J. Rewers
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108769- (2024)
Summary: Type 1 diabetes (T1D) is a chronic condition caused by autoimmune destruction of the insulin-producing pancreatic β cells. While it is known that gene-environment interactions play a key role in triggering the autoimmune process leading to
Externí odkaz:
https://doaj.org/article/acc4fc3a7d7e468abe5144f230ae4843
Autor:
Ernesto S. Nakayasu, Marina A. Gritsenko, Young-Mo Kim, Jennifer E. Kyle, Kelly G. Stratton, Carrie D. Nicora, Nathalie Munoz, Kathleen M. Navarro, Daniel Claborne, Yuqian Gao, Karl K. Weitz, Vanessa L. Paurus, Kent J. Bloodsworth, Kelsey A. Allen, Lisa M. Bramer, Fernando Montes, Kathleen A. Clark, Grant Tietje, Justin Teeguarden, Kristin E. Burnum-Johnson
Publikováno v:
Military Medical Research, Vol 10, Iss 1, Pp 1-21 (2023)
Abstract Background Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A b
Externí odkaz:
https://doaj.org/article/8d95b24435db469bbedea100bc80ed20
Autor:
Youngki You, Chia-Feng Tsai, Rishi Patel, Soumyadeep Sarkar, Geremy Clair, Mowei Zhou, Tao Liu, Thomas O. Metz, Chittaranjan Das, Ernesto S. Nakayasu
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Lysine carbamylation is a biomarker of rheumatoid arthritis and kidney diseases. However, its cellular function is understudied due to the lack of tools for systematic analysis of this post-translational modification (PTM). Method
Externí odkaz:
https://doaj.org/article/9726e3ddedfd445f827b3fc5a5232449
Autor:
Sneha P. Couvillion, Robert E. Danczak, Dan Naylor, Montana L. Smith, Kelly G. Stratton, Vanessa L. Paurus, Kent J. Bloodsworth, Yuliya Farris, Darren J. Schmidt, Rachel E. Richardson, Lisa M. Bramer, Sarah J. Fansler, Ernesto S. Nakayasu, Jason E. McDermott, Thomas O. Metz, Mary S. Lipton, Janet K. Jansson, Kirsten S. Hofmockel
Publikováno v:
Microbiome, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Background Microbiomes contribute to multiple ecosystem services by transforming organic matter in the soil. Extreme shifts in the environment, such as drying-rewetting cycles during drought, can impact the microbial metabolism of organic ma
Externí odkaz:
https://doaj.org/article/911829cd983242c7847f34849a073ec4
Autor:
Lisa M. Bramer, Robert D. Hontz, Amie J. Eisfeld, Amy C. Sims, Young-Mo Kim, Kelly G. Stratton, Carrie D. Nicora, Marina A. Gritsenko, Athena A. Schepmoes, Osamu Akasaka, Michiko Koga, Takeya Tsutsumi, Morio Nakamura, Ichiro Nakachi, Rie Baba, Hiroki Tateno, Shoji Suzuki, Hideaki Nakajima, Hideaki Kato, Kazunari Ishida, Makoto Ishii, Yoshifumi Uwamino, Keiko Mitamura, Vanessa L. Paurus, Ernesto S. Nakayasu, Isaac K. Attah, Andrew G. Letizia, Katrina M. Waters, Thomas O. Metz, Karen Corson, Yoshihiro Kawaoka, Vincent R. Gerbasi, Hiroshi Yotsuyanagi, Kiyoko Iwatsuki-Horimoto
Publikováno v:
Heliyon, Vol 9, Iss 3, Pp e13795- (2023)
The detailed mechanisms of COVID-19 infection pathology remain poorly understood. To improve our understanding of SARS-CoV-2 pathology, we performed a multi-omics and correlative analysis of an immunologically naïve SARS-CoV-2 clinical cohort from b
Externí odkaz:
https://doaj.org/article/53d6cd1dfc184584aa9c45e5874a5dd0
Autor:
Sneha P. Couvillion, Katie E. Mostoller, Janet E. Williams, Ryan M. Pace, Izabel L. Stohel, Haley K. Peterson, Carrie D. Nicora, Ernesto S. Nakayasu, Bobbie-Jo M. Webb-Robertson, Mark A. McGuire, Michelle K. McGuire, Thomas O. Metz
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
There is growing interest in a functional understanding of milk-associated microbiota as there is ample evidence that host-associated microbial communities play an active role in host health and phenotype. Mastitis, characterized by painful inflammat
Externí odkaz:
https://doaj.org/article/07303f6497a64c2285eaea06e9447874
Autor:
Xiaofang Tang, Wei Wei, John M. Snowball, Ernesto S. Nakayasu, Sheila M. Bell, Charles Ansong, Xinhua Lin, Jeffrey A. Whitsett
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105667- (2023)
Summary: Eukaryotic cells transit through the cell cycle to produce two daughter cells. Dysregulation of the cell cycle leads to cell death or tumorigenesis. Herein, we found a subunit of the ER membrane complex, EMC3, as a key regulator of cell cycl
Externí odkaz:
https://doaj.org/article/4ca76f27195f4bcba447222a1f873aa2