Výsledky vyhledávání - "Ernesto Raúl, Caffarena"

Akademický článek

Caracterização do envelhecimento populacional no município do Rio de Janeiro: contribuições para políticas públicas sustentáveis

Autor: Davi da Silveira Barroso Alves, Maria Tereza Serrano Barbosa, Ernesto Raúl Caffarena, Alexandre Sousa da Silva

Publikováno v: Cadernos de Saúde Coletiva, Vol 24, Iss 1, Pp 63-69 (2016)

Resumo Objetivo Descrever o estágio do envelhecimento populacional no município do Rio de Janeiro. Métodos Estudo ecológico tendo como unidades de observação os 160 bairros que compõem o município, utilizando indicadores sociais e demográfic

Externí odkaz: https://doaj.org/article/fb77a2ff81d14db89d928a33d5499d51

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Akademický článek

Computational drug design strategies applied to the modelling of human immunodeficiency virus-1 reverse transcriptase inhibitors

Autor: Lucianna Helene Santos, Rafaela Salgado Ferreira, Ernesto Raúl Caffarena

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 110, Iss 7, Pp 847-864 (2015)

Reverse transcriptase (RT) is a multifunctional enzyme in the human immunodeficiency virus (HIV)-1 life cycle and represents a primary target for drug discovery efforts against HIV-1 infection. Two classes of RT inhibitors, the nucleoside RT inhibito

Externí odkaz: https://doaj.org/article/05c74e387a134f1693a9bf4fcb4c8975

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RASopathy Cohort of Patients Enrolled in a Brazilian Reference Center for Rare Diseases: A Novel Familial LZTR1 Variant and Recurrent Mutations

Autor: Natana Chaves Rabelo, Maria Eduarda Gomes, Isabelle de Oliveira Moraes, Juliana Cantagalli Pfisterer, Guilherme Loss de Morais, Deborah Antunes, Ernesto Raúl Caffarena, Juan Llerena Jr, Sayonara Gonzalez

Publikováno v: The Application of Clinical Genetics.

Natana Chaves Rabelo,1â 3 Maria Eduarda Gomes,1â 3 Isabelle de Oliveira Moraes,1â 3 Juliana Cantagalli Pfisterer,1â 3 Guilherme Loss de Morais,4 Deborah Antunes,5 Ernesto RaÃºl Caffarena,6 Juan Llerena Jr,1,2,7,8 Sayonara Gonzal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cfa7bb0b73b2833eb2c7df2275befd
https://www.dovepress.com/rasopathy-cohort-of-patients-enrolled-in-a-brazilian-reference-center--peer-reviewed-fulltext-article-TACG

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Akademický článek

Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme

Autor: Alcione Silva de Carvalho, Kelly Salomão, Solange Lisboa de Castro, Taline Ramos Conde, Helena Pereira da Silva Zamith, Ernesto Raúl Caffarena, Belinda Suzette Hall, Shane Robert Wilkinson, Núbia Boechat

Publikováno v: Memorias do Instituto Oswaldo Cruz, Vol 109, Iss 3, Pp 315-323 (2014)

Megazol (7) is a 5-nitroimidazole that is highly active against Trypanosoma cruzi and Trypanosoma brucei, as well as drug-resistant forms of trypanosomiasis. Compound 7 is not used clinically due to its mutagenic and genotoxic properties, but has bee

Externí odkaz: https://doaj.org/article/1caf3e9c12c141e58ce25d49f2b44a7d

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Akademický článek

Structural and Molecular Modeling Features of P2X Receptors

Autor: Luiz Anastacio Alves, João Herminio Martins da Silva, Dinarte Neto Moreira Ferreira, Antonio Augusto Fidalgo-Neto, Pedro Celso Nogueira Teixeira, Cristina Alves Magalhães de Souza, Ernesto Raúl Caffarena, Mônica Santos de Freitas

Publikováno v: International Journal of Molecular Sciences, Vol 15, Iss 3, Pp 4531-4549 (2014)

Currently, adenosine 5'-triphosphate (ATP) is recognized as the extracellular messenger that acts through P2 receptors. P2 receptors are divided into two subtypes: P2Y metabotropic receptors and P2X ionotropic receptors, both of which are found in vi

Externí odkaz: https://doaj.org/article/e3b50f0d1f3843818706cd91a874504f

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How does α

Autor: María Julia, Amundarain, Ernesto Raúl, Caffarena, Marcelo Daniel, Costabel

Publikováno v: Physical chemistry chemical physics : PCCP. 23(6)

The activation of GABAA receptors by the neurotransmitter gamma-aminobutyric acid mediates the rapid inhibition response in the central nervous system of mammals. Many neurological and mental health disorders arise from alterations in the structure o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc58fb2781ff52323b329bcf5d918558
https://pubmed.ncbi.nlm.nih.gov/33554986

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Modelagem molecular aliada ao aprendizado de máquina na busca por assinaturas de resistência a herbicidas em Acetolactato sintases (ALSs)

Autor: Letícia Xavier Silva Cantão

Publikováno v: Repositório Institucional da UFMG
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG

CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior Aproximadamente 60% dos pesticidas uti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::0ba609deb88342f4dea9edfb90a6061b

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Avaliação da seletividade de inibição de cisteíno proteases por chagasina através de estudos de dinâmica molecular de complexos proteicos

Autor: Núbia Prates Toman

Publikováno v: Repositório Institucional da UFMG
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG

CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior A chagasina, um inibidor endógeno de cisteíno proteases de Trypanosoma cruzi, regula a atividade da protease parasitária cruzaína durante o ciclo de vida do parasita. Experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::190d9730003e2e346ead2ac8516005a3

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Estudos de modelagem molecular dos mecanismos de afinidade relativa para quatro galantamínicos com potencial anti-Alzheimer

Autor: Rafael Eduardo Oliveira Rocha

Publikováno v: Repositório Institucional da UFMG
Universidade Federal de Minas Gerais (UFMG)
instacron:UFMG

A doença de Alzheimer é atualmente um sério problema de saúde pública e econômico oriundo do aumento da expectativa de vida da população mundial, que resulta em complicados sintomas psicológicos em portadores dessa doença e reflete em devas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::602024f1cbca50892ca7cdf1135b2f64

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