Výsledky vyhledávání - "Ernesto Quesada"

Antinociceptive and modulatory effect of pathoplastic changes in spinal glia of a TLR4/CD14 blocking molecule in two models of pain in rat

Autor: Miguel M. García, Miguel Molina-Álvarez, Carmen Rodríguez-Rivera, Nancy Paniagua, Ernesto Quesada, José Antonio Uranga, María Isabel Rodríguez-Franco, David Pascual, Carlos Goicoechea

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The role of spinal glia in the development and maintenance of chronic pain has become over the last years a subject of increasing interest. In this regard, toll-like receptor 4 (TLR4) signaling has been proposed as a major trigger mechanism. Hence, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d33b3217c494762c1c91206108827e1c
https://pubmed.ncbi.nlm.nih.gov/35462333

Zobrazit plný text záznamu

Identification of L. infantum trypanothione synthetase inhibitors with leishmanicidal activity from a (non-biased) in-house chemical library

Autor: Mercedes Alcón-Calderón, Héctor de Lucio, Juan Carlos García-Soriano, Alejandro Revuelto, Sonia de Castro, Celia López-Gutiérrez, Ana San-Félix, Ernesto Quesada, Federico Gago, María-José Camarasa, Antonio Jiménez-Ruiz, Sonsoles Velázquez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Redox homeostasis in trypanosomatids is based on the low-molecular-weight trypanothione, an essential dithiol molecule that is synthetized by trypanothione synthetase (TryS) and maintained in its reduced state by trypa- nothione disulfide reductase (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ffb3a98ac776176e5a689cd192aca99
http://hdl.handle.net/10261/279364

Zobrazit plný text záznamu

Double Arylation of the Indole Side Chain of Tri- and Tetrapodal Tryptophan Derivatives Renders Highly Potent HIV-1 and EV-A71 Entry Inhibitors

Autor: Belén Martínez-Gualda, Arnaud Boonen, María-José Camarasa, Rana Abdelnabi, Ana San-Félix, Ernesto Quesada, Liang Sun, Johan Neyts, Sofía de la Puente-Secades, Sam Noppen, Alberto Mills, Dominique Schols, Olaia Martí-Marí, Federico Gago

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Medicinal Chemistry

This work is dedicated to Prof. Jan Balzarini (KU Leuven, Belgium), on the occasion of his retirement, in recognition of his constant encouragement and exemplary dedication to virology.
We have recently described a new generation of potent human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308b4aaf14bd7bfb5d3666fe32d497c8
https://lirias.kuleuven.be/handle/123456789/678648

Zobrazit plný text záznamu

TLR4 Antagonism Reduces Movement-Induced Nociception and ATF-3 Expression in Experimental Osteoarthritis

Autor: David Pascual, Miguel M. Garcia, Fani Neto, Carlos Goicoechea, Ernesto Quesada, José Manuel Castro-Lopes, Lígia Moreira Almeida, Diana S. Nascimento, Joana Ferreira-Gomes

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Pain Research

Toll-like receptor 4 (TLR4) is a pattern recognition receptor involved in the detection of pathogen-associated molecular patterns (PAMPs), but also a “danger-sensing” receptor that recognizes host-derived endogenous molecules called damage-associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517c2edd356e56f5d0b5dc299c70e7ba
http://hdl.handle.net/10261/250150

Zobrazit plný text záznamu

Scaffold Simplification Strategy Leads to a Novel Generation of Dual Human Immunodeficiency Virus and Enterovirus-A71 Entry Inhibitors

Autor: María-José Camarasa, Dominique Schols, Hyunwook Lee, Ernesto Quesada, Olaia Martí-Marí, Belén Martínez-Gualda, Johan Neyts, Carol M. Bator, Rana Abdelnabi, Liang Sun, Federico Gago, Sam Noppen, Carmen Mirabelli, Leen Delang, Susan Hafenstein, Ana San-Félix

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Currently, there are only three FDA-approved drugs that inhibit human immunodeficiency virus (HIV) entry-fusion into host cells. The situation is even worse for enterovirus EV71 infection for which no antiviral therapies are available. We describe he

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cab4f43d762548c866b545faae6b17
https://pubmed.ncbi.nlm.nih.gov/31809045

Zobrazit plný text záznamu

RNase II regulates RNase PH and is essential for cell survival during starvation and stationary phase

Autor: Ernesto Quesada, Shaheen Sulthana, Murray P. Deutscher

Publikováno v: RNA. 23:1456-1464

RNase II is the most active exoribonuclease in Escherichia coli cell extracts. Yet, its removal appears to have no deleterious effect on growing cells. Here, we show that RNase II is required for cell survival during prolonged stationary phase and up

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76963172afdc33c4a737a9f25df396c2
https://doi.org/10.1261/rna.060558.116

Zobrazit plný text záznamu

Optimization of a Class of Tryptophan Dendrimers That Inhibit HIV Replication Leads to a Selective, Specific, and Low-Nanomolar Inhibitor of Clinical Isolates of Enterovirus A71

Autor: Ana San-Félix, Pieter Leyssen, Belén Martínez-Gualda, Leen Delang, Johan Neyts, Eva Rivero-Buceta, Ernesto Quesada, María-José Camarasa, Kim Donckers, Liang Sun, Elisa G. Doyagüez

Publikováno v: Antimicrobial Agents and Chemotherapy
Digital.CSIC. Repositorio Institucional del CSIC
instname

Tryptophan dendrimers that inhibit HIV replication by binding to the HIV envelope glycoproteins gp120 and gp41 have unexpectedly also proven to be potent, specific, and selective inhibitors of the replication of the unrelated enterovirus A71. Dendrim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5ef15c4fb01bb0a0a1d101e59e9f4b
https://doi.org/10.1128/aac.00626-16

Zobrazit plný text záznamu

Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity

Autor: Ernesto Quesada, Eva-María Priego, Sam Noppen, María-Jesús Pérez-Pérez, Oskía Bueno, Sandra Liekens, Juan Estévez-Gallego, María-José Camarasa, Gloria Tobajas, José-Fernando Díaz

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Based on the conformation of the α-methyl chalcone TUB091 in its complex with tubulin, a series of conformational mimetics have been designed and synthesized where the methyl group of the chalcone has been fused to phenyl ring B resulting in 1,2,3,4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7115a69ae845ac20d146ec543fa106c1
http://hdl.handle.net/10261/170941

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání