Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ernesto Luna-Melendez"'
Autor:
Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna-Melendez, James B. McNamara, Connor I. White, William Knight, Saisrinidhi Ganta, Zorana Opachich, Claudia Cantoni, Wonsuk Yoo, Nader Sanai, Artak Tovmasyan, Shwetal Mehta
Publikováno v:
JCI Insight, Vol 8, Iss 22 (2023)
Histone deacetylase (HDAC) inhibitors have garnered considerable interest for the treatment of adult and pediatric malignant brain tumors. However, owing to their broad-spectrum nature and inability to effectively penetrate the blood-brain barrier, H
Externí odkaz:
https://doaj.org/article/fde3c2b5ee5b4f4fac16366a31d2b804
Autor:
Evgenii Belykh, Liudmila Bardonova, Irakliy Abramov, Vadim A. Byvaltsev, Talgat Kerymbayev, Kwanha Yu, Debbie R. Healey, Ernesto Luna-Melendez, Benjamin Deneen, Shwetal Mehta, James K. Liu, Mark C. Preul
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionSurgical resection remains the first-line treatment for gliomas. Several fluorescent dyes are currently in use to augment intraoperative tumor visualization, but information on their comparative effectiveness is lacking. We performed syst
Externí odkaz:
https://doaj.org/article/0b85742c6cd147619b79293caec7d598
Autor:
Shwetal Mehta, Gregory H. Turner, Michael T. Lawton, S. Paul Oh, Candice L Nguyen, Ernesto Luna Melendez, Michael J. Lang, Chul Han
Publikováno v:
Journal of Neurosurgery. 137:163-174
OBJECTIVE Hereditary hemorrhagic telangiectasia is the only condition associated with multiple inherited brain arteriovenous malformations (AVMs). Therefore, a mouse model was developed with a genetics-based approach that conditionally deleted the ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e20dfb5a9b3e1060301e613369b8d9
https://doi.org/10.3171/2021.6.jns21717
https://doi.org/10.3171/2021.6.jns21717
Autor:
René Daer, Cassandra M Barrett, Ernesto Luna Melendez, Jiaqi Wu, Stefan J Tekel, Jimmy Xu, Brady Dennison, Ryan Muller, Karmella A Haynes
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202294 (2018)
Quorum sensing networks have been identified in over one hundred bacterial species to date. A subset of these networks regulate group behaviors, such as bioluminescence, virulence, and biofilm formation, by sending and receiving small molecules calle
Externí odkaz:
https://doaj.org/article/603be5ecbd2f49b0afe01fe57ba46a2e
Autor:
Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna Melendez, James B. McNamara, Connor I. White, William Knight, Saisrinidhi Ganta, Zorana Opachich, Wonsuk Yoo, Nader Sanai, Artak Tovmasyan, Shwetal Mehta
In recent years, histone deacetylase inhibitors (HDACi) have garnered considerable interest for the treatment of adult and pediatric malignant brain tumors. However, owing to their broad-spectrum nature and inability to effectively penetrate the bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc4ab56dacefae808da6f2c208e663de
https://doi.org/10.1101/2022.11.09.515859
https://doi.org/10.1101/2022.11.09.515859
Autor:
Shwetal Mehta, Jun Jiang, Barbara Hopkins, Jing Li, Artak Tovmasyan, Garry Hook, Nader Sanai, Ernesto Luna Melendez
Publikováno v:
Neuro Oncol
BACKGROUND Lysine specific demethylase 1 (LSD1) is a histone demethylase implicated in the maintenance of pluripotency and proliferation gene programs that give rise to a number of cancers. SP-2577 is a first-in-class selective and reversible inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aca58d7c0b3ed833f38ac89674e7239
https://europepmc.org/articles/PMC8598443/
https://europepmc.org/articles/PMC8598443/
Autor:
Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna Melendez, James McNamara, William Knight, Connor White, Zorana Opachich, Niddhi Ganta, Alexis Giff, Nader Sanai, Artak Tovmasyan, Shwetal Mehta
Publikováno v:
Neuro-Oncology. 24:vii216-vii216
Glioblastoma (GBM) is characterized by an aberrant yet druggable epigenetic landscape. Class I HDACs mediate chromatin compaction and are frequently overexpressed in GBM. Hence, there has been considerable interest in HDAC inhibitors (HDACi) for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c11ad2c1768018e37f16e5d5446e1c92
https://doi.org/10.1093/neuonc/noac209.829
https://doi.org/10.1093/neuonc/noac209.829
Autor:
James McNamara, Ernesto Luna Melendez, Nader Sanai, Matthew E. Dufault, Shwetal Mehta, Erika M. Lewis, Costanza Lo Cascio, Christopher L. Plaisier
Publikováno v:
JCI Insight
Glioblastoma (GBM) is characterized by an aberrant yet druggable epigenetic landscape. One major family of epigenetic regulators, the histone deacetylases (HDACs), are considered promising therapeutic targets for GBM due to their repressive influence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03ad53dd9122d50bdd858731dbf2bd0
https://doi.org/10.1172/jci.insight.149232
https://doi.org/10.1172/jci.insight.149232
Autor:
Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna Melendez, James McNamara, William Knight, Sarah Himes, Connor White, Alexis Giff, Jesus Peralta, Nader Sanai, Artak Tovmasyan, Shwetal Mehta
Publikováno v:
Cancer Research. 82:349-349
Glioblastoma (GBM), the most common and aggressive primary brain tumor affecting adults, is characterized by an aberrant yet druggable epigenetic landscape. Class I histone deacetylases (HDACs) mediate chromatin compaction and are frequently overexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ec62b5b3a2cf9a38ffa8b7cbbdd9d73
https://doi.org/10.1158/1538-7445.am2022-349
https://doi.org/10.1158/1538-7445.am2022-349
Autor:
Nader Sanai, Arantxa Cebrián-Silla, José Manuel García-Verdugo, Ernesto Luna Melendez, Shwetal Mehta, Roberto Fiorelli, Gurpaul S. Sidhu
To address the inefficiency of passive diffusion for antibody penetration in thick tissue samples, which limits clearing-technique applications, we developed a versatile and simple device to perform antibody incubation under increased barometric pres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::952a4cb3ec36fd1c7de1beb3daa1b038
https://doi.org/10.1101/2020.09.25.311936
https://doi.org/10.1101/2020.09.25.311936