Zobrazeno 1 - 10
of 334
pro vyhledávání: '"Ernesto Canalis"'
Publikováno v:
PLoS ONE, Vol 17, Iss 5 (2022)
Notch receptors are determinants of cell fate and function, and play an important role in the regulation of bone development and skeletal remodeling. Lateral Meningocele Syndrome (LMS) is a monogenic disorder associated with NOTCH3 pathogenic variant
Externí odkaz:
https://doaj.org/article/905ef0c0df8b4b55a38bde93f5dca455
Autor:
Song Ho Chang, Daisuke Mori, Hiroshi Kobayashi, Yoshifumi Mori, Hideki Nakamoto, Keita Okada, Yuki Taniguchi, Shurei Sugita, Fumiko Yano, Ung-il Chung, Joo-ri Kim-Kaneyama, Motoko Yanagita, Aris Economides, Ernesto Canalis, Di Chen, Sakae Tanaka, Taku Saito
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Excessive mechanical stress promotes the development of osteoarthritis. Here Chang et al. identify gremlin-1 as a factor expressed in chondrocytes in response to mechanical stress, and contributing to osteoarthritis via activation of the NF-κB pathw
Externí odkaz:
https://doaj.org/article/89ba19c2f9a9477294c478b865fc68cf
Autor:
Ernesto Canalis
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
Notch (Notch1 through 4) are transmembrane receptors that determine cell differentiation and function, and are activated following interactions with ligands of the Jagged and Delta-like families. Notch has been established as a signaling pathway that
Externí odkaz:
https://doaj.org/article/eb847ff0af1345689d2518a9d9370cb9
Publikováno v:
Clinics, Vol 65, Iss 11, Pp 1197-1205 (2010)
The aim of this article is to review rheumatological diseases that are associated with glucocorticoid-induced osteoporosis or fractures and to perform a critical analysis of the current guidelines and treatment regimens. The electronic database MEDLI
Externí odkaz:
https://doaj.org/article/7e1e400aca2248529d560803b9755c9f
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0120164 (2015)
We previously reported that the ability of continuously elevated PTH to stimulate osteoblastic differentiation in bone marrow stromal cell cultures was abrogated by an osteoclastic factor secreted in response to cyclooxygenase-2 (Cox2)-produced prost
Externí odkaz:
https://doaj.org/article/1d37f2d2651c44ab80492ae91b273b49
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86757 (2014)
Sex and genetic factors determine skeletal mass, and we tested whether bone histomorphometric parameters were sexually dimorphic in femurs from 1 to 6 month old C57BL/6 mice. Trabecular bone volume declined more rapidly in female mice than in male li
Externí odkaz:
https://doaj.org/article/b9213c688b57432ba4edc62ae4f15b27
Publikováno v:
Nature Reviews Endocrinology. 18:353-365
Publikováno v:
Bone. 172:116760
Autor:
Anna Peterson, Mikayla Moody, Brian Wingender, Katya Morozov, Iris Nakashima, Margaret Easson, Ron Abraham, Tannin A. Schmidt, Leslie Caromile, Ernesto Canalis, Alix Deymier
Publikováno v:
SSRN Electronic Journal.
Publikováno v:
J Cell Physiol
The present study defines the function of nuclear factor of activated T cells (NFAT)c1 and NFATc2 in osteoblast function in vivo and in vitro. Nfatc1loxP/loxP , Nfatc2loxP/loxP , and Nfatc1loxP/loxP ;Nfatc2loxP/loxP conditional mice were mated with B