Zobrazeno 1 - 10
of 182
pro vyhledávání: '"Ernesto Bernal"'
Autor:
Jacqueline F. Machi, Isabella Altilio, Yue Qi, Alejo A. Morales, Diego H. Silvestre, Diana R. Hernandez, Nicolas Da Costa-Santos, Aline G. Santana, Mehrnoosh Neghabi, Parisa Nategh, Thiago L. Castro, João P. Werneck-de-Castro, Mahsa Ranji, Fabiana S. Evangelista, Roberto I. Vazquez-Padron, Ernesto Bernal-Mizrachi, Claudia O. Rodrigues
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: Obesity is a major risk factor associated with multiple pathological conditions including diabetes and cardiovascular disease. Endothelial dysfunction is an early predictor of obesity. However, little is known regarding how early endoth
Externí odkaz:
https://doaj.org/article/70b92df7ee8c4458b29ae8f173c4258e
Autor:
Judy Z. Louie, Dov Shiffman, Charles M. Rowland, Norma S. Kenyon, Ernesto Bernal-Mizrachi, Michael J. McPhaul, Rajesh Garg
Publikováno v:
Clinical Diabetes and Endocrinology, Vol 10, Iss 1, Pp 1-8 (2024)
Abstract Background Professional guidelines recommend an HbA1c 8.5% within 3 years from their last HbA1c were included in analysis. Patients were grouped as improved glycemic control (last HbA1c ≤ 8.5%) or lack of improvement (last HbA1c > 8.5%). M
Externí odkaz:
https://doaj.org/article/ef12b0c86b5c403194af57ff2313cba1
Autor:
Ernesto Bernal Martinez
Publikováno v:
Pensamiento Crítico, Vol 28, Iss 2, Pp 5-21 (2023)
El objetivo de este estudio de investigación es calcular el efecto de las crisis, como las fluctuaciones en los precios de los recursos naturales, la crisis subprime, la política y la pandemia de covid-19, en el producto interno bruto y la inflaci
Externí odkaz:
https://doaj.org/article/19a387b647214913bb4a793e17a660ec
Autor:
Manuel Blandino-Rosano, Ruy Andrade Louzada, Joao Pedro Werneck-De-Castro, Camila Lubaczeuski, Joana Almaça, Markus A. Rüegg, Michael N. Hall, Gil Leibowitz, Ernesto Bernal-Mizrachi
Publikováno v:
Molecular Metabolism, Vol 75, Iss , Pp 101769- (2023)
Objective: The essential role of raptor/mTORC1 signaling in β-cell survival and insulin processing has been recently demonstrated using raptor knock-out models. Our aim was to evaluate the role of mTORC1 function in adaptation of β-cells to insulin
Externí odkaz:
https://doaj.org/article/492f65d1d70946308c8773653d0f3eef
Autor:
Camila Lubaczeuski, Nadejda Bozadjieva-Kramer, Ruy A. Louzada, George K. Gittes, Gil Leibowitz, Ernesto Bernal-Mizrachi
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Elevation of glucagon levels and increase in α cell proliferation is associated with states of hyperglycemia in diabetes. A better understanding of the molecular mechanisms governing glucagon secretion could have major implications for understanding
Externí odkaz:
https://doaj.org/article/1d792ae902e4459aa59bbae29c82b927
Autor:
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112529- (2023)
Summary: Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide
Externí odkaz:
https://doaj.org/article/557572b83b5a4a7ca84c9f23c0810f39
Autor:
Aviram Kogot-Levin, Yael Riahi, Ifat Abramovich, Ofri Mosenzon, Bella Agranovich, Liat Kadosh, Rachel Ben-Haroush Schyr, Doron Kleiman, Liad Hinden, Erol Cerasi, Danny Ben-Zvi, Ernesto Bernal-Mizrachi, Joseph Tam, Eyal Gottlieb, Gil Leibowitz
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Diabetes is associated with increased risk for kidney disease, heart failure, and mortality. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) prevent these adverse outcomes; however, the mechanisms involved are not clear. We generated a roadmap of
Externí odkaz:
https://doaj.org/article/49358b6776da4385b24f9cb12f16a15f
Autor:
Søs Skovsø, Evgeniy Panzhinskiy, Jelena Kolic, Haoning Howard Cen, Derek A. Dionne, Xiao-Qing Dai, Rohit B. Sharma, Lynda Elghazi, Cara E. Ellis, Katharine Faulkner, Stephanie A. M. Marcil, Peter Overby, Nilou Noursadeghi, Daria Hutchinson, Xiaoke Hu, Hong Li, Honey Modi, Jennifer S. Wildi, J. Diego Botezelli, Hye Lim Noh, Sujin Suk, Brian Gablaski, Austin Bautista, Ryekjang Kim, Corentin Cras-Méneur, Stephane Flibotte, Sunita Sinha, Dan S. Luciani, Corey Nislow, Elizabeth J. Rideout, Eric N. Cytrynbaum, Jason K. Kim, Ernesto Bernal-Mizrachi, Laura C. Alonso, Patrick E. MacDonald, James D. Johnson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Insulin receptor protein is present in pancreatic β-cells, but the consequences of β-cell insulin resistance are incompletely understood. Here the authors use a combination of mouse studies and mathematical modelling to show that loss of beta-cell
Externí odkaz:
https://doaj.org/article/34fcff15f65143fa8ca0bab84b4cd93e
Autor:
Joao Pedro Werneck-de-Castro, Flavia Leticia Martins Peçanha, Diego Henrique Silvestre, Ernesto Bernal-Mizrachi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Mechanistic target of rapamycin complex 1 (mTORC1) deficiency or chronic hyperactivation in pancreatic β-cells leads to diabetes. mTORC1 complexes with La-related protein 1 (LARP1) to specifically regulate the expression of 5′ terminal ol
Externí odkaz:
https://doaj.org/article/f414533262e4418686e776c61f76aed1
Autor:
Brian Akhaphong, Brigid Gregg, Doga Kumusoglu, Seokwon Jo, Kanakadurga Singer, Joshua Scheys, Jennifer DelProposto, Carey Lumeng, Ernesto Bernal-Mizrachi, Emilyn U. Alejandro
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2022)
The risk of obesity in adulthood is subject to programming in the womb. Maternal obesity contributes to programming of obesity and metabolic disease risk in the adult offspring. With the increasing prevalence of obesity in women of reproductive age t
Externí odkaz:
https://doaj.org/article/277f63bd9df249f2b439a8696c2ffd74