Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Ernesto A Salegio"'
Autor:
Ernesto A Salegio, Hillary eStreeter, Nikhil eDube, Piotr eHadaczek, Lluis eSamaranch, Adrian eKells, Waldy eSan Sebastián, Yuying eZhai, John eBringas, Ting eXu, John eForsayeth, Krystof S Bankiewicz
Publikováno v:
Frontiers in Neuroanatomy, Vol 8 (2014)
When nanoparticles/proteins are infused into the brain, they are often transported to distal sites in a manner that is dependent both on the characteristics of the infusate and the region targeted. We have previously shown that AAV is disseminated wi
Externí odkaz:
https://doaj.org/article/b0eb87363bc24d62addd143fed6f5a4b
Autor:
Kathryn Hammond Rosenbluth, Francisco Gimenez, Adrian P Kells, Ernesto A Salegio, Gabriele M Mittermeyer, Kevin Modera, Anmol Kohal, Krystof S Bankiewicz
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e64452 (2013)
This study presents a computational tool for auto-segmenting the distribution of brain infusions observed by magnetic resonance imaging. Clinical usage of direct infusion is increasing as physicians recognize the need to attain high drug concentratio
Externí odkaz:
https://doaj.org/article/c9c08fa091204c18a652820f8b68016c
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
While the majority of gene therapy studies in neurological indications have focused on direct gene transfer to the central nervous system (CNS), there is growing interest in the delivery of therapeutics using the cerebrospinal fluid (CSF) as a condui
Externí odkaz:
https://doaj.org/article/e5838633442242acbb44929238cacfbb
Autor:
Jesus G. Cruz-Garza, Khaled M. Taghlabi, Lokeshwar S. Bhenderu, Shruti Gupta, Arvind Pandey, Allison M. Frazier, Shawn Brisbay, John D. Patterson, Ernesto A. Salegio, Christopher J. Kantorak, Christof Karmonik, Philip J. Horner, Robert C. Rostomily, Amir H. Faraji
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc62dc228e6dc681ac9434b1b2d6e2b3
https://doi.org/10.3791/64079
https://doi.org/10.3791/64079
Autor:
Shervin Jannesar, Ernesto A. Salegio, Carolyn J. Sparrey, Jacqueline C. Bresnahan, Michael S. Beattie
Publikováno v:
J Neurotrauma
Non-human primate (NHP) models are the closest approximation of human spinal cord injury (SCI) available for pre-clinical trials. The NHP models, however, include broader morphological variability that can confound experimental outcomes. We developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fe9726ebefe572546f241589676260
https://doi.org/10.1089/neu.2019.6840
https://doi.org/10.1089/neu.2019.6840
Autor:
Shervin Jannesar, Ernesto A. Salegio, Cesar Jimenez, Mark H. Tuszynski, Ephron S. Rosenzweig, Michael S. Beattie, Jacqueline C. Bresnahan, Carolyn J. Sparrey
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2184eedd7ba4871920991d3bf1749cb
https://doi.org/10.2139/ssrn.4073489
https://doi.org/10.2139/ssrn.4073489
Autor:
Marc Gonzalez, Granger G.C. Hwa, Diane E. Stockinger, Summer Copeland, Emily Lambert, Mira J. Cukrov, Abigail Green, Jeremy M. Yeung, Rachel Lortz, Ernesto A. Salegio
Publikováno v:
Human gene therapy. 33(1-2)
In this study, we built upon our previous work to demonstrate the distribution and transport of AAV5-GFP following a single CED infusion into the nonhuman primate cerebellum, with no untoward side effects noted. Dosing under MRI guidance revealed a 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d69b788ee0f30f2b2abba78b422105
https://pubmed.ncbi.nlm.nih.gov/34779239
https://pubmed.ncbi.nlm.nih.gov/34779239
Autor:
Lluis Samaranch, John Forsayeth, Waldy San Sebastian, Krystof S. Bankiewicz, Ernesto A. Salegio, Philip C. Allen, Piotr Hadaczek, Haifeng Chen, Michael V. Campagna, Jerusha Naidoo, Granger G.C. Hwa, Kousaku Ohno, John Bringas, Vivek Sudhakar, Diane E. Stockinger, Christopher Snieckus
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 47-54 (2019)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Here we evaluated the utility of MRI to monitor intrathecal infusions in nonhuman primates. Adeno-associated virus (AAV) spiked with gadoteridol, a gadolinium-based MRI contrast agent, enabled real-time visualization of infusions delivered either via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e868c604fb9c50fcf1cdebefedd028e
http://www.sciencedirect.com/science/article/pii/S2329050118301232
http://www.sciencedirect.com/science/article/pii/S2329050118301232
Autor:
Jacqueline C. Bresnahan, Shervin Jannesar, Sarah Mills, Carolyn J. Sparrey, Anne M. Gibbons, Mark Allen, Ernesto A. Salegio
Publikováno v:
Acta Biomaterialia. 74:260-269
The goal of developing computational models of spinal cord injury (SCI) is to better understand the human injury condition. However, finite element models of human SCI have used rodent spinal cord tissue properties due to a lack of experimental data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f4edcfc9359406d8b319ad206cd1ae
https://doi.org/10.1016/j.actbio.2018.05.002
https://doi.org/10.1016/j.actbio.2018.05.002
Autor:
Rod Moseanko, Leif A. Havton, Ernesto A. Salegio, Mark H. Tuszynski, James W. Fawcett, Adam R. Ferguson, Janet L. Weber, Jennifer Iaci, Stephanie Hawbecker, J. Russell Huie, Yvette S. Nout-Lomas, Barbara Haenzi, John H. Brock, Roger Pender, Jacqueline C. Bresnahan, Michael S. Beattie, Andrew R. Blight, Chase A. Weinholtz, Ephron S. Rosenzweig, Christina Cruzen, Justine J. Liang, Anthony O. Caggiano
Publikováno v:
Nature neuroscience, vol 22, iss 8
Nature neuroscience
Nature neuroscience
Inhibitory extracellular matrices form around mature neurons as perineuronal nets containing chondroitin sulfate proteoglycans that limit axonal sprouting after CNS injury. The enzyme chondroitinase (Chase) degrades inhibitory chondroitin sulfate pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8634f8d08ce496622c66fd92d80d94be
https://escholarship.org/uc/item/1n72g749
https://escholarship.org/uc/item/1n72g749
