Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Ernesto A B F Lima"'
Autor:
Caleb M Phillips, Ernesto A B F Lima, Manasa Gadde, Angela M Jarrett, Marissa Nichole Rylander, Thomas E Yankeelov
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1009499 (2023)
The goal of this study is to calibrate a multiscale model of tumor angiogenesis with time-resolved data to allow for systematic testing of mathematical predictions of vascular sprouting. The multi-scale model consists of an agent-based description of
Externí odkaz:
https://doaj.org/article/657e6e13a4c148c4963b9b30f13482e2
Autor:
Ernesto A B F Lima, Danial Faghihi, Russell Philley, Jianchen Yang, John Virostko, Caleb M Phillips, Thomas E Yankeelov
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11, p e1008845 (2021)
Hybrid multiscale agent-based models (ABMs) are unique in their ability to simulate individual cell interactions and microenvironmental dynamics. Unfortunately, the high computational cost of modeling individual cells, the inherent stochasticity of c
Externí odkaz:
https://doaj.org/article/ea275e01d87f4f20bc0e61114344f1e5
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231137 (2020)
Tumor associated angiogenesis is the development of new blood vessels in response to proteins secreted by tumor cells. These new blood vessels allow tumors to continue to grow beyond what the pre-existing vasculature could support. Here, we construct
Externí odkaz:
https://doaj.org/article/c8c342bbbb3d42b497feba2570ed9bdf
Autor:
Kaitlyn E Johnson, Grant Howard, William Mo, Michael K Strasser, Ernesto A B F Lima, Sui Huang, Amy Brock
Publikováno v:
PLoS Biology, Vol 17, Iss 8, p e3000399 (2019)
Most models of cancer cell population expansion assume exponential growth kinetics at low cell densities, with deviations to account for observed slowing of growth rate only at higher densities due to limited resources such as space and nutrients. Ho
Externí odkaz:
https://doaj.org/article/b9865c052a504627a1961fd4354b951f
Autor:
Hugo J. M. Miniere, Ernesto A. B. F. Lima, Guillermo Lorenzo, David A. Hormuth II, Sophia Ty, Amy Brock, Thomas E. Yankeelov
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
ABSTRACTTumor heterogeneity contributes significantly to chemoresistance, a leading cause of treatment failure. To better personalize therapies, it is essential to develop tools capable of identifying and predicting intra- and inter-tumor heterogenei
Externí odkaz:
https://doaj.org/article/0e280a58802b47fcb80eb711f4c69ab3
Model selection for assessing the effects of doxorubicin on triple-negative breast cancer cell lines
Autor:
Anna Claudia M. Resende, Ernesto A. B. F. Lima, Regina C. Almeida, Matthew T. McKenna, Thomas E. Yankeelov
Publikováno v:
Journal of Mathematical Biology. 85
Autor:
Chengyue Wu, Casey E. Stowers, Zhan Xu, Ernesto A. B. F. Lima, Clinton Yam, Jong Bum Son, Jingfei Ma, Gaiane M. Rauch, Thomas E. Yankeelov
Publikováno v:
Cancer Research. 83:5569-5569
Introduction: Patients with locally advanced, triple-negative breast cancer (TNBC) typically receive neoadjuvant systemic therapy (NAST). However, the response of TNBC to NAST is varied and a prognostic marker is still lacking. Since angiogenesis pla
Autor:
Aureliano S. S. Paiva, Rosemeire L. Fiaccone, Luciana L. Cardim, Rafael V. Veiga, Caio P. de Castro, Moreno S. Rodrigues, Felipe A. C. Pereira, Pablo Ivan Pereira Ramos, Ernesto A. B. F. Lima, Suani Tavares Rubim de Pinho, Juliane F. Oliveira, Daniel C. P. Jorge, Diego S. Souza, Roberto F. S. Andrade, Alan A. S. Amad, Matheus F. Torquato, Nívea B. da Silva
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
COVID-19 is affecting healthcare resources worldwide, with lower and middle-income countries being particularly disadvantaged to mitigate the challenges imposed by the disease, including the availability of a sufficient number of infirmary/ICU hospit
Autor:
Chengyue Wu, Guillermo Lorenzo, David A. Hormuth, Ernesto A. B. F. Lima, Kalina P. Slavkova, Julie C. DiCarlo, John Virostko, Caleb M. Phillips, Debra Patt, Caroline Chung, Thomas E. Yankeelov
Publikováno v:
Biophys Rev (Melville)
Biophysics Reviews
Biophysics Reviews
Digital twins employ mathematical and computational models to virtually represent a physical object (e.g., planes and human organs), predict the behavior of the object, and enable decision-making to optimize the future behavior of the object. While d
Autor:
Matthew T. McKenna, Angela M. Jarrett, Ernesto A. B. F. Lima, Thomas E. Yankeelov, David Fuentes, David A. Hormuth
Publikováno v:
JCO Clinical Cancer Informatics. :1-10
Multiparametric imaging is a critical tool in the noninvasive study and assessment of cancer. Imaging methods have evolved over the past several decades to provide quantitative measures of tumor and healthy tissue characteristics related to, for exam