Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ernesto, Gargiulo"'
Autor:
Ernesto Gargiulo, Pablo Elias Morande, Maxmilan Jeyakumar, Lucie Rospape, Jérôme Paggetti, Etienne Moussay
Publikováno v:
STAR Protocols, Vol 5, Iss 3, Pp 103244- (2024)
Summary: Here, we present a protocol for the direct isolation of small extracellular vesicles (sEVs) from the spleen of preclinical murine models of leukemia using ultracentrifugation. We describe steps for tissue collection, sample preparation, ultr
Externí odkaz:
https://doaj.org/article/c477576d1f794bb5ae2e4d4a651d8847
Autor:
Carmen Formisano, Nunzio Fiorentino, Ida Di Mola, Nunzia Iaccarino, Ernesto Gargiulo, Giuseppina Chianese
Publikováno v:
Frontiers in Plant Science, Vol 15 (2024)
Phytocannabinoids represent the hallmark of the secondary metabolism of Cannabis sativa. The content of major phytocannabinoids is closely related to genetic variation as well as abiotic elicitors such as temperature, drought, and saline stress. The
Externí odkaz:
https://doaj.org/article/f4eab29ad97a4e1ca67fb039367c9989
Autor:
Mohaned Benzarti, Laura Neises, Anais Oudin, Christina Krötz, Elodie Viry, Ernesto Gargiulo, Coralie Pulido, Maryse Schmoetten, Vitaly Pozdeev, Nadia I. Lorenz, Michael W. Ronellenfitsch, David Sumpton, Marc Warmoes, Christian Jaeger, Antoine Lesur, Björn Becker, Etienne Moussay, Jerome Paggetti, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113868- (2024)
Summary: Modeling tumor metabolism in vitro remains challenging. Here, we used galactose as an in vitro tool compound to mimic glycolytic limitation. In contrast to the established idea that high glycolytic flux reduces pyruvate kinase isozyme M2 (PK
Externí odkaz:
https://doaj.org/article/70167f7828434ce29cdc23c2703e97a7
Autor:
Anne Largeot, Vanessa Klapp, Elodie Viry, Susanne Gonder, Iria Fernandez Botana, Arnaud Blomme, Mohaned Benzarti, Sandrine Pierson, Chloé Duculty, Petra Marttila, Marina Wierz, Ernesto Gargiulo, Giulia Pagano, Ning An, Najla El Hachem, Daniel Perez Hernandez, Supriya Chakraborty, Loic Ysebaert, Jean-Hugues François, Susan Cortez, Guy Berchem, Dimitar G Efremov, Gunnar Dittmar, Martyna Szpakowska, Andy Chevigne, Petr V. Nazarov, Thomas Helleday, Pierre Close, Johannes Meiser, Basile Stamatopoulos, Laurent Désaubry, Jérôme Paggetti, Etienne Moussay
Publikováno v:
HemaSphere, Vol 7, p e52627ab (2023)
Externí odkaz:
https://doaj.org/article/cadb7e0ab439425bb2d02339f658e7b0
Autor:
Giulia Pagano, Iria Fernandez Botana, Marina Wierz, Philipp M. Roessner, Nikolaos Ioannou, Xiangda Zhou, Gheed Al-Hity, Coralie Borne, Ernesto Gargiulo, Susanne Gonder, Bin Qu, Basile Stamatopoulos, Alan G. Ramsay, Martina Seiffert, Anne Largeot, Etienne Moussay, Jerome Paggetti
Publikováno v:
Haematologica, Vol 108, Iss 11 (2023)
Chronic lymphocytic leukemia (CLL) cells are highly dependent on interactions with the immunosuppressive tumor microenvironment (TME) for survival and proliferation. In the search for novel treatments, pro-inflammatory cytokines have emerged as candi
Externí odkaz:
https://doaj.org/article/f29683a86d924b2e8fdf058bdcf1c6eb
Autor:
Ernesto Gargiulo, Emanuela Roscetto, Umberto Galdiero, Giuseppe Surico, Maria Rosaria Catania, Antonio Evidente, Orazio Taglialatela-Scafati
Publikováno v:
Biomolecules, Vol 14, Iss 1, p 134 (2024)
Lampedusa, the largest island of the Pelagie archipelago, Sicily, Italy, has proven to be a rich source of plants and shrubs used in folk medicine. These plants, often native to the island, have been very poorly investigated for their phytochemical c
Externí odkaz:
https://doaj.org/article/2e2c7fb1986c41199699267891d8da90
The protective role of the microenvironment in hairy cell leukemia treatment: Facts and perspectives
Autor:
Ernesto Gargiulo, Mirta Giordano, Carsten U. Niemann, Etienne Moussay, Jérôme Paggetti, Pablo Elías Morande
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Hairy cell leukemia (HCL) is an incurable, rare lymphoproliferative hematological malignancy of mature B cAlthough first line therapy with purine analogues leads to positive results, almost half of HCL patients relapse after 5-10 years, and standard
Externí odkaz:
https://doaj.org/article/12379cf97fc2489581ae1fd6af876f86
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8+ T-cells, inducing exhaustion and ham
Externí odkaz:
https://doaj.org/article/2442a5f52a1d4cfe86c1d3ff30f7f638
Autor:
Rosaria Francolino, Mara Martino, Lucia Caputo, Giuseppe Amato, Giuseppina Chianese, Ernesto Gargiulo, Carmen Formisano, Benedetta Romano, Giuseppe Ercolano, Angela Ianaro, Laura De Martino, Vincenzo De Feo
Publikováno v:
Antioxidants, Vol 12, Iss 8, p 1633 (2023)
Rosmarinus officinalis L. is an aromatic evergreen plant from the Lamiaceae family. The purpose of this study was to compare the chemical profile and bioactivities of hydroalcoholic extracts derived from wild and cultivated R. officinalis. The chemic
Externí odkaz:
https://doaj.org/article/f7385ab7aa654b5fb4a4b7ebb7afd75e
Autor:
Alexia Vereertbrugghen, Ana Colado, Ernesto Gargiulo, Raimundo Fernando Bezares, Horacio Fernández Grecco, Gregorio Cordini, Maria del Rosario Custidiano, Jean-Hugues François, Guy Berchem, Mercedes Borge, Jerome Paggetti, Etienne Moussay, Romina Gamberale, Mirta Giordano, Pablo Elías Morande
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Current standard treatment of patients with hairy cell leukemia (HCL), a chronic B-cell neoplasia of low incidence that affects the elderly, is based on the administration of purine analogs such as cladribine. This chemotherapy approach shows satisfa
Externí odkaz:
https://doaj.org/article/8023bcc1246e4bd080357aa16d54a4d1