Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Ernest Sirimanne"'
Autor:
Naomi L. Baker, Arjan Scheepens, Erica J. Beilharz, Vincenzo C. Russo, Chris E. Williams, Bronwyn Connor, Ernest Sirimanne, George A. Werther, Gary Butler, Peter D. Gluckman, Mike Dragunow
Publikováno v:
Molecular Brain Research. 59:119-134
Insulin-like growth factor 1 (IGF-1) is induced after hypoxic-ischemic (HI) brain injury, and therapeutic studies suggest that IGF-1 may restrict delayed neuronal and glial cell loss. We have used a well-characterised rat model of HI injury to extend
Autor:
D Bossano, Mark Gunning, Chris E. Williams, R M Blumberg, Alexander D. Edwards, Ernest Sirimanne, Peter D. Gluckman
Publikováno v:
Pediatric Research. 39:591-597
Hypoxic-ischemic injuries can evolve over several days, and recent studies suggest that further neuronal death may occur 6 to 72 h later. Because cerebral temperature is an important determinant of outcome during the primary injury, we investigated t
Publikováno v:
Neuroscience. 70:1013-1024
Injury to the central nervous system initiates a series of signals that control cell survival and rearrangement, leading to some functional recovery. Using a unilateral model of hypoxic-ischemic brain injury, we report strong induction of inhibin bet
Autor:
Ernest Sirimanne, A D Edwards, B M Johnston, Chris E. Williams, E C Mallard, I. Roberts, Kyla Marks, Peter D. Gluckman
Publikováno v:
Pediatric Research. 39:48-54
The study investigated the hypothesis that delayed cerebral injury after transient cerebral ischemia is associated with vasoconstriction and decreased cerebral oxygenation. Eight chronically instrumented, late gestation fetal sheep were subjected to
Publikováno v:
Molecular Brain Research. 29:1-14
The mechanisms leading to delayed cell death following hypoxic-ischemic injury in the developing brain are unclear. We examined the possible roles of apoptosis and microglial activation in the 21-day-old rat brain following either mild (15 min) or se
Publikováno v:
Behavioural brain research. 235(2)
The hippocampus processes memory is an early target of aging-related biological and structural lesions, leading to memory decline. With absent neurodegeneration in the hippocampus, which identified in rodent model of normal aging the pathology underl
Publikováno v:
Journal of Neuroscience Methods. 55:7-14
Hypoxic-ischaemic (HI) brain injury can lead to selective neuronal loss or pannecrosis. Different mechanisms of damage and recovery may be associated with either pattern of cell loss. Two preparations were developed to investigate the role of growth
Autor:
Erica J. Beilharz, Rodrigo Bravo, Ernest Sirimanne, Mike Dragunow, P. Lawlor, Peter Gluckman, Chris E. Williams
Publikováno v:
Molecular Brain Research. 25:19-33
A unilateral hypoxia-ischaemia (HI) 21-day-old rat preparation was used to assess the effects of HI on the expression of the immediate-early gene proteins (IEGPs) c-Fos/FRAs, Fos B, c-Jun, Jun B, Jun D, Krox 20, Krox 24, and on the mRNA for the neuro
Autor:
Mike Dragunow, K. Singleton, P. Lawlor, G.A. MacGibbon, Paul E. Hughes, Peter D. Gluckman, Erica J. Beilharz, Deborah Young, Ernest Sirimanne
Publikováno v:
Molecular Brain Research. 18:347-352
Neurons undergoing delayed neuronal death produced by hypoxia-ischaemia (HI) or status epilepticus (SE) showed a massive expression of c-Jun in their nuclei 24 h after the insult. With SE there was also a weaker induction of c-Fos and Jun B in dying
Autor:
Peter D. Gluckman, N.D. Klempt, M. Klempt, Erica J. Beilharz, Ernest Sirimanne, Mike Dragunow
Publikováno v:
Molecular Brain Research. 18:209-215
Recent studies suggest a role for the insulin-like growth factor (IGF) system in the repair of damaged tissue following hypoxic-ischemic injury in the infant rat brain. We have used a unilateral model of hypoxic-ischemic injury to assess the possible