Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Ernest Sargsyan"'
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Long-term exposure to elevated levels of free fatty acids (FFAs) is deleterious for beta-cell function and may contribute to development of type 2 diabetes mellitus (T2DM). Whereas mechanisms of impaired glucose-stimulated insulin
Externí odkaz:
https://doaj.org/article/822eedc2b8a94c5e8fb0068b109b8e12
Autor:
Kirsten Roomp, Hjalti Kristinsson, Domitille Schvartz, Kumari Ubhayasekera, Ernest Sargsyan, Levon Manukyan, Azazul Chowdhury, Hannes Manell, Venkata Satagopam, Karlfried Groebe, Reinhard Schneider, Jonas Bergquist, Jean-Charles Sanchez, Peter Bergsten
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176391 (2017)
Studies on the pathophysiology of type 2 diabetes mellitus (T2DM) have linked the accumulation of lipid metabolites to the development of beta-cell dysfunction and impaired insulin secretion. In most in vitro models of T2DM, rodent islets or beta-cel
Externí odkaz:
https://doaj.org/article/055aa27969e34e85bb37f586ef083dea
Autor:
Astghik Abrahamyan, Jodene Eldstrom, Harutyun Sahakyan, Nare Karagulyan, Liana Mkrtchyan, Tatev Karapetyan, Ernest Sargsyan, Matthias Kneussel, Karen Nazaryan, Jürgen R. Schwarz, David Fedida, Vitya Vardanyan
Publikováno v:
Journal of General Physiology. 155
KCNQ1 voltage-gated K+ channels are involved in a wide variety of fundamental physiological processes and exhibit the unique feature of being markedly inhibited by external K+. Despite the potential role of this regulatory mechanism in distinct physi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02aead83fc429d419d5fd0ebbb54d45c
https://doi.org/10.1085/jgp.202213205
https://doi.org/10.1085/jgp.202213205
Publikováno v:
Journal of Molecular Endocrinology. 61:91-99
Elevated levels of palmitate accentuate glucose-stimulated insulin secretion (GSIS) after short-term and cause beta-cell dysfunction after prolonged exposure. We investigated whether metformin, the first-line oral drug for treatment of T2DM, has bene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d20fad38059c3fd1e3978c65425537
https://doi.org/10.1530/jme-17-0304
https://doi.org/10.1530/jme-17-0304
Autor:
Rakan Naboulsi, Peter Bergsten, Xiaofang Cao, Shady Younis, Mårten Larsson, Nils Welsh, Ernest Sargsyan, Leif Andersson, Xuan Wang
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 34(8)
The transcription factor ZBED6 acts as a repressor of Igf2 and affects directly or indirectly the transcriptional regulation of thousands of genes. Here, we use gene editing in mouse C2C12 myoblasts and show that ZBED6 regulates Igf2 exclusively thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ef8612a1f8052604ae47511a369ed9
https://pubmed.ncbi.nlm.nih.gov/32557799
https://pubmed.ncbi.nlm.nih.gov/32557799
Autor:
Leif Andersson, Rakan Naboulsi, Malin Larsson, Peter Bergsten, Nils Welsh, Shady Younis, Ernest Sargsyan, Xiaofang Cao, Xuan Wang
SUMMARYThe transcription factor ZBED6 acts as a repressor ofIgf2and affects directly or indirectly the transcriptional regulation of thousands of genes. Here, we use gene editing in mouse C2C12 myoblasts and show that ZBED6 regulatesIgf2exclusively t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41cdf3d29540ec0db429b70cc124abd0
https://doi.org/10.1101/540914
https://doi.org/10.1101/540914
Autor:
Daniel Weghuber, Fanni Zsoldos, Johan Staaf, Hannes Manell, Ernest Sargsyan, Janne Cadamuro, Jonas Bergquist, Katharina Mörwald, Anders Forslund, Håkan Ahlström, Peter Bergsten, Sven Göpel, Sarojini J.K.A. Ubhayasekera, Joel Kullberg, Hjalti Kristinsson
Objective: To delineate mechanisms for fasting hyperglucagonemia in childhood obesity bystudying the associations between fasting plasma glucagon concentrations and plasmalipid parameters and fat compartments. Methods: Cross-sectional study of childr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76acd37285293b87460e0e38aea17d29
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-380313
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-380313
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(3)
The naturally occurring quassinoid compound brusatol improves the survival of insulin-producing cells when exposed to the proinflammatory cytokines IL-1β and IFN-γ in vitro. The aim of the present study was to investigate whether brusatol also prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::501b1000d126e17d89c09991259dedb0
https://pubmed.ncbi.nlm.nih.gov/30462531
https://pubmed.ncbi.nlm.nih.gov/30462531
Autor:
Reinhard Schneider, Domitille Schvartz, Jean-Charles Sanchez, Ernest Sargsyan, Karlfried Groebe, Anders Alderborn, Peter Bergsten, Azazul Islam Chowdhury, Kirsten Roomp, Jing Cen
Publikováno v:
Journal of Proteome Research, Vol. 17, No 11 (2018) pp. 3824-3836
In obese children with high circulating concentrations of free fatty acid palmitate, we have observed that insulin levels at fasting and in response to a glucose challenge were several times higher than in obese children with low concentrations of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2125b05b7c1c1a1a7c2eb84892bfd2
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369592
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-369592
Publikováno v:
Endocrinology; Vol 154
Free fatty acids (FFAs) have pleiotropic effects on the pancreatic β-cell. Although acute exposure to FFAs stimulates glucose-stimulated insulin secretion (GSIS), prolonged exposure impairs GSIS and causes apoptosis. FFAs exert their effects both vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f0f11c6139fde79d90f700e209f0da