Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Ernest S. Smith"'
Autor:
Ernest S. Smith, Leslie A. Balch, Maria Scrivens, Shuying Shi, Wei Wang, Caroline D. Harvey, Angelica A. Cornelison, Malgorzata Gil-Moore, Renee A. Kirk, Loretta L. Mueller, Richard L. Hall, Alan P. Howell, Christine A. Reilly, Jessica M. Mayer, Francis G. Murante, Kari A Viggiani, Elaine M. Gersz, Holm Bussler, Madeleine R. Keefe, Elizabeth E. Evans, Mark J. Paris, Maurice Zauderer
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTAntibody discovery against complex antigens is limited by the availability of a reproducible pure source of concentrated properly folded antigen. We have developed a technology to enable direct incorporation of membrane proteins such as GPCRs
Externí odkaz:
https://doaj.org/article/c402db932a18479db56dc8edfe5b355e
Autor:
Christoph Klenk, Maria Scrivens, Anina Niederer, Shuying Shi, Loretta Mueller, Elaine Gersz, Maurice Zauderer, Ernest S. Smith, Ralf Strohner, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
G protein-coupled receptors are a major class of drug targets. Here, the authors develop a method whereby their biophysical and functional properties can be altered through directed evolution in mammalian cells, leading to variants exhibiting feature
Externí odkaz:
https://doaj.org/article/b76be3cffcda479f9ff2db12a5dfd09a
Autor:
Elizabeth E. Evans, Vikas Mishra, Crystal Mallow, Elaine M. Gersz, Leslie Balch, Alan Howell, Christine Reilly, Ernest S. Smith, Terrence L. Fisher, Maurice Zauderer
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background The close interaction and interdependence of astrocytes and neurons allows for the possibility that astrocyte dysfunction contributes to and amplifies neurodegenerative pathology. Molecular pathways that trigger reactive astrocyte
Externí odkaz:
https://doaj.org/article/01b6646059f34cdbb38b673af2c1aec2
Autor:
Amber L. Southwell, Sonia Franciosi, Erika B. Villanueva, Yuanyun Xie, Laurie A. Winter, Janaki Veeraraghavan, Alan Jonason, Boguslaw Felczak, Weining Zhang, Vlad Kovalik, Sabine Waltl, George Hall, Mahmoud A. Pouladi, Ernest S. Smith, William J. Bowers, Maurice Zauderer, Michael R. Hayden
Publikováno v:
Neurobiology of Disease, Vol 76, Iss , Pp 46-56 (2015)
Huntington disease (HD) is an inherited, fatal neurodegenerative disease with no disease-modifying therapy currently available. In addition to characteristic motor deficits and atrophy of the caudate nucleus, signature hallmarks of HD include behavio
Externí odkaz:
https://doaj.org/article/99a93dc1282c4cf6b5dc56f2438c4a79
Autor:
Ernest S. Smith, Alan Jonason, Christine Reilly, Janaki Veeraraghavan, Terrence Fisher, Michael Doherty, Ekaterina Klimatcheva, Crystal Mallow, Chad Cornelius, John E. Leonard, Nicola Marchi, Damir Janigro, Azeb Tadesse Argaw, Trinh Pham, Jennifer Seils, Holm Bussler, Sebold Torno, Renee Kirk, Alan Howell, Elizabeth E. Evans, Mark Paris, William J. Bowers, Gareth John, Maurice Zauderer
Publikováno v:
Neurobiology of Disease, Vol 73, Iss , Pp 254-268 (2015)
Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by immune cell infiltration of CNS, blood–brain barrier (BBB) breakdown, localized myelin destruction, and progressive neuronal degeneration. There exists a significant ne
Externí odkaz:
https://doaj.org/article/9200aa0f032041e08e2248710c9d6c10
Autor:
Maurice Zauderer, Ernest S. Smith, Mark Paris, William J. Bowers, Terrence L. Fisher, Katya Klimatcheva, Maria Scrivens, Susan Giralico, Alan Howell, Renee Kirk, Crystal Mallow, Laurie A. Winter, Jennifer Seils, Michael A. Doherty, Christine Reilly, Janaki Veeraraghavan, Sebold Torno, Holm Bussler, Alan S. Jonason, Elizabeth E. Evans
Analysis and statistics for tumor growth, survival and CR: Immunohistochemistry methods.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c7f9c6525bdc53d65ad79007e8f1a18
https://doi.org/10.1158/2326-6066.22538348
https://doi.org/10.1158/2326-6066.22538348
Autor:
Maurice Zauderer, Ernest S. Smith, Christine Reilly, Chad A. Cornelius, Laurie A. Winter, Terrence L. Fisher, John E. Leonard
Supplemental Methods: Nonclinical Safety Evaluation of VX15/2503; a Humanized IgG4 Anti-SEMA4D Antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3774c01cfea91b9668675fc49e3ef1fd
https://doi.org/10.1158/1535-7163.22499830.v1
https://doi.org/10.1158/1535-7163.22499830.v1
Autor:
Maurice Zauderer, Ernest S. Smith, Christine Reilly, Chad A. Cornelius, Laurie A. Winter, Terrence L. Fisher, John E. Leonard
The humanized IgG4 monoclonal antibody VX15/2503 bound with 1 to 5 nmol/L affinity to purified recombinant semaphorin 4D (SEMA4D; CD100) produced using murine, rat, cynomolgus macaque, and human sequences. The affinity for native SEMA4D expressed on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b623f950c834e4e92e057a195de4b1dc
https://doi.org/10.1158/1535-7163.c.6536278
https://doi.org/10.1158/1535-7163.c.6536278
Autor:
Maurice Zauderer, Ernest S. Smith, Mark Paris, William J. Bowers, Terrence L. Fisher, Katya Klimatcheva, Maria Scrivens, Susan Giralico, Alan Howell, Renee Kirk, Crystal Mallow, Laurie A. Winter, Jennifer Seils, Michael A. Doherty, Christine Reilly, Janaki Veeraraghavan, Sebold Torno, Holm Bussler, Alan S. Jonason, Elizabeth E. Evans
Supplementary Figure S1: SEMA4D and PLXNB1 are highly expressed in human cancer. Supplementary Figure S2: SEMA4D gradient at tumor leading edge. Supplementary Figure S3: Tumor volumes of mice selected for immune cell characterization and functional a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3e741fdd3c1064046f9b7911f212d3
https://doi.org/10.1158/2326-6066.22538351.v1
https://doi.org/10.1158/2326-6066.22538351.v1
Autor:
Maurice Zauderer, Ernest S. Smith, Mark Paris, William J. Bowers, Terrence L. Fisher, Katya Klimatcheva, Maria Scrivens, Susan Giralico, Alan Howell, Renee Kirk, Crystal Mallow, Laurie A. Winter, Jennifer Seils, Michael A. Doherty, Christine Reilly, Janaki Veeraraghavan, Sebold Torno, Holm Bussler, Alan S. Jonason, Elizabeth E. Evans
Semaphorin 4D (SEMA4D, CD100) and its receptor plexin-B1 (PLXNB1) are broadly expressed in murine and human tumors, and their expression has been shown to correlate with invasive disease in several human tumors. SEMA4D normally functions to regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f46dcb34992473e0cbb195d9773fa727
https://doi.org/10.1158/2326-6066.c.6548750.v1
https://doi.org/10.1158/2326-6066.c.6548750.v1