Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Ernest S. Paight"'
1
Bioisosteric replacement of the hydrazide pharmacophore of the cannabinoid-1 receptor antagonist SR141716A. Part I: Potent, orally-active 1,4-disubstituted imidazoles
Autor: Marlys Hammond, David A. Griffith, Philip A. Carpino, Steven R. Schneider, Robert L. Dow, Paul DaSilva-Jardine, John R. Hadcock, Philip A. Iredale, Dennis O. Scott, Ernest S. Paight
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:5351-5354
A new series of CB(1) receptor antagonists incorporating an imidazole-based isosteric replacement for the hydrazide moiety of rimonabant (SR141716) is disclosed. Members of this imidazole series possess potent/selective binding to the rCB(1) receptor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4fb2f93da026a0faa073ffb8e71095a
https://doi.org/10.1016/j.bmcl.2009.07.130
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3
4-Amino-5-aryl-6-arylethynylpyrimidines: Structure–activity relationships of non-nucleoside adenosine kinase inhibitors
Autor: Steven W. Muchmore, Elizabeth A. Kowaluk, Kennan C. Marsh, Steve McGaraughty, Haixia Yu, Arthur Gomtsyan, Andrew O. Stewart, Shripad S. Bhagwat, Michael F. Jarvis, Karen M. Alexander, Kathy L. Kohlhaas, Clarissa L. Jakob, Chih-Hung Lee, Robin R. Frey, Mark A. Matulenko, Ernest S. Paight, Joseph P. Mikusa, Meiqun Jiang, Stanley Didomenico
Publikováno v: Bioorganic & Medicinal Chemistry. 15:1586-1605
A series of non-nucleoside adenosine kinase (AK) inhibitors is reported. These inhibitors originated from the modification of 5-(3-bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine (ABT-702). The identification of a linker
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96eaee04592b0c71e6be749106b4cef1
https://doi.org/10.1016/j.bmc.2006.12.029
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5
Synthesis and characterisation of some [M(C3S5)2]n− complexes (M = Ni, Pd, Pt). Single crystal structure of [PPN] [Ni(C3S5)2] · MeOH
Autor: Jerry P. Jasinski, Harkesh B. Singh, Ernest S. Paight, Kochurani, Ray J. Butcher
Publikováno v: Polyhedron. 16:3505-3510
The synthesis and characterisation of some anionic Ni, Pd and Pt complexes of the ligand, Na2C3S5, (C3S52− = 1,3-dithiole-2-thione-4,5-dimercapto = dmit) are reported. The complexes were isolated as PPN+ [PPN+ = bis(triphenylphosphine)iminium] salt
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bd2d0173e29c54d6446dcf1698c09e2
https://doi.org/10.1016/s0277-5387(97)00131-9
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6
Synthesis and characterization of the complexes of trimethylplatinum(IV) iodide with some ditellurides and ditelluroethers: The crystal structure of [(PtIMe3)2(p-MeOC6H4Te)2]
Autor: Ray J. Butcher, Jerry P. Jasinski, V. Anna Regini, Harkesh B. Singh, Ernest S. Paight
Publikováno v: Journal of Organometallic Chemistry. 466:283-289
Trimethylplatinum(IV) iodide reacts with ditellurides, R 2 Te 2 , to give bimetallic complexes of the type [(PtIMe 3 ) 2 (Te 2 R 2 )] (R = Me, p -MeOC 6 H 4 , p -EtOC 6 H 4 ). Ditelluroethers, RTeCH 2 TeR, react with trimethylplatinum(IV) iodide to g
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280b6160930ae9372ce277cd7ef3a4cf
https://doi.org/10.1016/0022-328x(94)88057-3
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7
New π-electron donors for organic metals: synthesis of substituted tetrathiafulvalenes with eight- and nine-membered dithiaheterocycles: crystal structure of 5,6,7,8-tetrahydro-1,3-dithiolo[4,5-b][1,4]dithiocine-2-thione
Autor: Ray J. Butcher, S. Kalyan Kumar, Jerry P. Jasinski, Ernest S. Paight, Harkesh B. Singh
Publikováno v: J. Chem. Soc., Perkin Trans. 1. :3341-3347
Reaction of the dimercapto disodium salt 2 with 1,4-dibromobutane, dibromo-o-xylene, 1,8-bis(bromomethyl) naphthalene and 1,2,4,5-tetrakis(bromomethyl)benzene gave the thiones 3, 5, 8 and 11 respectively. The thiones 5 and 8 were oxidised to give the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4dfd740aa0fc93d42daf1ef6eb83d137
https://doi.org/10.1039/p19910003341
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8
3-(2-Benzothiazolyl)-7-(diethylamino)coumarin
Autor: J. P. Jasinski, Ernest S. Paight
Publikováno v: Acta Crystallographica Section C Crystal Structure Communications. 51:531-533
The coumarin and benzothiazolyl ring systems in the title compound, C 20 H 18 N 2 O 2 S, are planar. The pyrone ring in the coumarin moiety is bent slightly (2.30 o ) compared to the thiazolyl ring in the benzothiazolyl moiety. The crystal structure
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e20dc7e0a3f8ca568487bd0844c44a99
https://doi.org/10.1107/s0108270194003628
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9
7-Dimethylamino-4-trifluoromethylcoumarin, a new polymeric form
Autor: J. P. Jasinski, Ernest S. Paight
Publikováno v: Acta Crystallographica Section C Crystal Structure Communications. 50:1928-1930
This molecule represents a new polymorph of the title laser-dye aminocoumarin compound, C 12 H 10 F 3 NO 2 . Torsion angles in the trifluoro moiety and intermolecular packing effects indicate significant structural differences when compared to its po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4400178c2b20a519d43c3a8e81fa6a58
https://doi.org/10.1107/s0108270194003616
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