Zobrazeno 1 - 10 of 108 pro vyhledávání: '"Ernest S, Han"'
1
Akademický článek
Evolution of core archetypal phenotypes in progressive high grade serous ovarian cancer
Autor: Aritro Nath, Patrick A. Cosgrove, Hoda Mirsafian, Elizabeth L. Christie, Lance Pflieger, Benjamin Copeland, Sumana Majumdar, Mihaela C. Cristea, Ernest S. Han, Stephen J. Lee, Edward W. Wang, Sian Fereday, Nadia Traficante, Ravi Salgia, Theresa Werner, Adam L. Cohen, Philip Moos, Jeffrey T. Chang, David D. L. Bowtell, Andrea H. Bild
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
High-grade serous ovarian cancer (HGSOC) is prone to developing resistance to treatment. Here, the authors use single-cell RNA-seq and an analysis of archetypes, and find that shifts in metabolism and proliferation are associated with the response to
Externí odkaz: https://doaj.org/article/ae3e02320d4947c59945469a2cf43f04
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2
Akademický článek
Increasing Antitumor Activity of JAK Inhibitor by Simultaneous Blocking Multiple Survival Signaling Pathways in Human Ovarian Cancer
Autor: Wei Wen, Ernest S. Han, Thanh H. Dellinger, Jun Wu, Yuming Guo, Ralf Buettner, David A. Horne, Richard Jove, John H. Yim
Publikováno v: Translational Oncology, Vol 12, Iss 8, Pp 1015-1025 (2019)
Many signaling pathways, including the JAK/STAT3 pathway, are aberrantly activated and associated with ovarian cancer growth and progression. However, inhibition of STAT3 pathway alone was not sufficient to effectively block human ovarian cancer cell
Externí odkaz: https://doaj.org/article/e1ccf5e8c5a947d1a3452a3aebed2df8
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3
A Phase III Study of Pafolacianine Injection (OTL38) for Intraoperative Imaging of Folate Receptor–Positive Ovarian Cancer (Study 006)
Autor: Janos L. Tanyi, Leslie M. Randall, Setsuko K. Chambers, Kristina A. Butler, Ira S. Winer, Carrie L. Langstraat, Ernest S. Han, Alexander L. Vahrmeijer, Hye Sook Chon, Mark A. Morgan, Matthew A. Powell, Jill H. Tseng, Alexis S. Lopez, Robert M. Wenham
Publikováno v: Journal of Clinical Oncology. 41:276-284
PURPOSE The adjunctive use of intraoperative molecular imaging (IMI) is gaining acceptance as a potential means to improve outcomes for surgical resection of targetable tumors. This confirmatory study examined the use of pafolacianine for real-time d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd4fdc6538df0ea93326e8bff0edbb24
https://doi.org/10.1200/jco.22.00291
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5
Colorectal cancer ovarian metastases
Autor: Lucas W. Thornblade, Yuman Fong, Ernest S. Han
Publikováno v: International Journal of Gynecologic Cancer. 31:1137-1144
ObjectiveOvarian metastases occur in 3%–5% of patients with colorectal cancer. The role of oophorectomy in that setting continues to be debated. We aimed to assess the survival of women treated with metastasectomy for ovarian metastasis.MethodsRetr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78f0abfc10707dac6a8de21743e54d20
https://doi.org/10.1136/ijgc-2020-002328
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6
Akademický článek
Eribulin Synergistically Increases Anti-Tumor Activity of an mTOR Inhibitor by Inhibiting pAKT/pS6K/pS6 in Triple Negative Breast Cancer
Autor: Wei Wen, Emily Marcinkowski, David Luyimbazi, Thehang Luu, Quanhua Xing, Jin Yan, Yujun Wang, Jun Wu, Yuming Guo, Dylan Tully, Ernest S. Han, Susan E. Yost, Yuan Yuan, John H. Yim
Publikováno v: Cells, Vol 8, Iss 9, p 1010 (2019)
Unlike other breast cancer subtypes, patients with triple negative breast cancer (TNBC) have poor outcomes and no effective targeted therapies, leaving an unmet need for therapeutic targets. Efforts to profile these tumors have revealed the PI3K/AKT/
Externí odkaz: https://doaj.org/article/15a6b56ccdc14ad9ae6bb106813588c7
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9
Readmission and complications after robotic surgery: experience of 10,000 operations at a comprehensive cancer center
Autor: Ellie Maghami, Mark T. Wakabayashi, Gagandeep Singh, Jae Y. Kim, Yuman Fong, Dan J. Raz, Alessio Pigazzi, Jim Shen, Pooya Banapour, Ernest S. Han, Avinash Chenam, Nora Ruel, Bertram Yuh, Yanghee Woo, Clayton Lau
Publikováno v: Journal of Robotic Surgery. 15:37-44
Evaluation of safety is of paramount importance with adoption of novel surgical technology. Although robotic surgery has become widely used in oncologic surgery, analysis of safety is lacking in comparison to traditional techniques. Standardized asse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d90d4d9650791ce8f52a0e827cd7238
https://doi.org/10.1007/s11701-020-01077-4
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10
Akademický článek
Pterostilbene Suppresses Ovarian Cancer Growth via Induction of Apoptosis and Blockade of Cell Cycle Progression Involving Inhibition of the STAT3 Pathway
Autor: Wei Wen, Gina Lowe, Cai M. Roberts, James Finlay, Ernest S. Han, Carlotta A. Glackin, Thanh Hue Dellinger
Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 7, p 1983 (2018)
A growing body of evidence has demonstrated the promising anti-tumor effects of resveratrol in ovarian cancer cells, including its inhibitory effects on STAT3 activation. Nonetheless, the low bioavailability of resveratrol has reduced its attractiven
Externí odkaz: https://doaj.org/article/81e2aa0fe24748f0904e8ec587f22a00
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