Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Ernest Medina"'
Autor:
Steffan T. Nawrocki, Devalingam Mahalingam, Ernest Medina, Kevin R. Kelly, Jennifer S. Carew, Jeffrey Ecsedy, Swaminathan Padmanabhan, Francis J. Giles
Publikováno v:
Journal of Cellular and Molecular Medicine
Novel therapies are urgently needed to prevent and treat tyrosine kinase inhibitor resistance in chronic myeloid leukaemia (CML). MLN8237 is a novel Aurora A kinase inhibitor under investigation in multiple phase I and II studies. Here we report that
Autor:
Swaminathan Padmanabhan, Kevin R. Kelly, Michael O'Dwyer, Ronan T. Swords, James Garnsey, Kelli Oberheu, Ernest Medina, Peter G. Smith, Jennifer S. Carew, Steffan T. Nawrocki, Devalingam Mahalingam, Francis J. Giles
Publikováno v:
Blood. 115:3796-3800
NEDD8 activating enzyme (NAE) has been identified as an essential regulator of the NEDD8 conjugation pathway, which controls the degradation of many proteins with important roles in cell-cycle progression, DNA damage, and stress responses. Here we re
Autor:
Kelli Oberheu, Alain C. Mita, Kevin R. Kelly, Steffan T. Nawrocki, Ernest Medina, Jennifer S. Carew, Claudia M. Espitia, Sabrina Smith, Ronan T. Swords, Juan A. Esquivel, Devalingam Mahalingam, Francis J. Giles, Monica M. Mita
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 16(1)
Purpose: The mammalian target of rapamycin (mTOR) inhibitor temsirolimus has exhibited promising anticancer activity for the treatment of renal cell cancers (RCC). Survivin expression has been implicated in drug resistance and reducing its levels wit
Autor:
Peng Huang, Ronan T. Swords, Hui Zhang, Francis J. Giles, Steffan T. Nawrocki, Monica M. Mita, Alain C. Mita, Ernest Medina, Devalingam Mahalingam, Jennifer S. Carew, Kevin R. Kelly, Juan A. Esquivel
Publikováno v:
Journal of Cellular and Molecular Medicine
Autophagy is an evolutionarily conserved cell survival pathway that enables cells to recoup ATP and other critical biosynthetic molecules during nutrient deprivation or exposure to hypoxia, which are hallmarks of the tumour microenvironment. Autophag
Autor:
Kelli Oberheu, Ernest Medina, Pietro Taverna, Steffan T. Nawrocki, Jennifer S. Carew, Kevin R. Kelly, Devalingam Mahalingam, Claudia M. Espitia, Gavin S. Choy, Francis J. Giles
Publikováno v:
Blood. 116:3253-3253
Abstract 3253 Drug resistance is a major cause of treatment failure for patients with acute myeloid leukemia (AML) and novel strategies that circumvent resistance mechanisms are urgently needed. The Pim kinases (PIM1, PIM2, PIM3) are a small family o
Autor:
Ronan T. Swords, Steven de Jong, Robbert Hans Cool, Devalingam Mahalingam, Francis J. Giles, Sanjay Bansal, Kevin R. Kelly, Steffan T. Nawrocki, Ernest Medina, Jennifer S. Carew
Publikováno v:
Cancer Research. 70:669-669
Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis that may have promise as an anticancer agent due to its selectivity toward tumor cells. However, resistance to TRAIL occurs frequently and is primarily d
Autor:
Ernest Medina, Gavin S. Choy, Francis J. Giles, Jennifer S. Carew, Steffan T. Nawrocki, Ronan T. Swords, Pietro Taverna, Kevin R. Kelly, Devalingam Mahalingam, David J. Bearss
Publikováno v:
Molecular Cancer Therapeutics. 8:B272-B272
The PIM kinases (PIM1, PIM2, and PIM3) are constitutively active serine/threonine kinases that promote tumorigenesis in mouse models and are associated with drug resistance. Upregulation of PIM kinase expression has been reported in many malignancies
Autor:
Steffan T. Nawrocki, Ronan T. Swords, Ernest Medina, Devalingam Mahalingam, Jennifer S. Carew, Kevin R. Kelly, Francis J. Giles, Jeffrey Ecsedy, Swaminathan Padmanabhan, Sabrina Smith, Mary R. Cahill
Publikováno v:
Blood. 114:2087-2087
Abstract 2087 Poster Board II-64 Acute myeloid leukemia (AML) most frequently affects the elderly, many of whom are unable to tolerate intensive chemotherapy. Therefore, improvements in clinical outcomes for patients with AML largely depend upon the
Autor:
Devalingam Mahalingam, C. H. Robbert, Ernest Medina, Jennifer S. Carew, G. J. Francis, de Steven Jong, Ronan T. Swords, Kevin R. Kelly, Steffan T. Nawrocki, Eva Szegezdi
Publikováno v:
Journal of Clinical Oncology. 27:e14633-e14633
e14633 Background: Tumor necrosis factor related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis, however not all cancers respond to TRAIL, which may be due to activation of survival signals. Sunitinib is a potent inhibitor of mult
Autor:
Ronan T. Swords, Jeffrey Ecsedy, Sabrina Smith, Francis J. Giles, Swaminathan Padmanabhan, Steffan T. Nawrocki, Kevin R. Kelly, Ernest Medina, Jennifer S. Carew
Publikováno v:
Blood. 112:3198-3198
The serine/threonine kinase Aurora A is a key regulator of mitosis. Its expression and activation are necessary for mitotic entry, centrosome maturation, and mitotic spindle assembly and function. Aurora A gene amplification and/or overexpression of