Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Ernest G. Peralta"'
Autor:
Ernest G. Peralta, Jennifer J. Hill
Publikováno v:
Journal of Biological Chemistry. 276:5505-5510
The G protein-coupled inwardly rectifying K+ channel, GIRK1/GIRK4, can be activated by receptors coupled to the Galpha(i) subunit. An opposing role for Galpha(q) receptor signaling in GIRK regulation has only recently begun to be established. We have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf05709ff82a8197a0b77a0002f9c55
https://doi.org/10.1074/jbc.m008213200
https://doi.org/10.1074/jbc.m008213200
Autor:
Eunice Y. Tsai, Hadley C. King, Brigitta M. N. Brinkman, Anthony D. Morielli, Anne E. Goldfeld, Menie Merika, Tom Maniatis, Dimitris Thanos, Ernest G. Peralta, James V. Falvo, Bhavin S. Parekh, Adele M. Uglialoro
Publikováno v:
Molecular and Cellular Biology. 20:2239-2247
The human tumor necrosis factor alpha (TNF-alpha) gene is rapidly activated in response to multiple signals of stress and inflammation. We have identified transcription factors present in the TNF-alpha enhancer complex in vivo following ionophore sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24b5c7eb10f7389a2d5f4fc646e2909
https://doi.org/10.1128/mcb.20.6.2239-2247.2000
https://doi.org/10.1128/mcb.20.6.2239-2247.2000
Publikováno v:
The Journal of General Physiology
Negative regulation of the heartbeat rate involves the activation of an inwardly rectifying potassium current (I(KACh)) by G protein-coupled receptors such as the m2 muscarinic acetylcholine receptor. Recent studies have shown that this process invol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456b67afee711ce06f0647b126040d26
http://europepmc.org/articles/PMC2229482
http://europepmc.org/articles/PMC2229482
Publikováno v:
Current Biology. 9(9):485-490
Ewing family tumors result from the effects of chromosomal translocations that fuse the Ewing sarcoma ( EWS ) gene to various genes encoding transcription factors [1]. The resulting chimeric EWS fusion proteins are transcriptional activators with tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::958738b5e671330d806196dd8a50fb88
Publikováno v:
Cell. 93:1077-1085
Tyrosine kinases activated by G protein–coupled receptors can phosphorylate and thereby suppress the activity of the delayed rectifier potassium channel Kv1.2. Using a yeast two-hybrid screen, we identified the small GTP-binding protein RhoA as a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38fcc348172bae32e46dcd25c60b908
https://doi.org/10.1016/s0092-8674(00)81212-x
https://doi.org/10.1016/s0092-8674(00)81212-x
Autor:
Reed C. Carroll, Ernest G. Peralta
Publikováno v:
The EMBO Journal. 17:3036-3044
Several types of transmembrane receptors regulate cellular responses through the activation of phospholipase C-mediated Ca2+ release from intracellular stores. In non-excitable cells, the initial Ca2+ release is typically followed by a prolonged Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ee881b947ff961208987f1dd6989f6
https://doi.org/10.1093/emboj/17.11.3036
https://doi.org/10.1093/emboj/17.11.3036
Publikováno v:
Proceedings of the National Academy of Sciences. 95:5051-5056
Several G protein-coupled receptors are known to direct the tyrosine phosphorylation, and in some cases the activation, of diverse tyrosine kinases. Using a stable cell line approach, we characterize the activation of PYK2, a tyrosine kinase structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf720e78e47dab871cd6beaae8bd188
https://doi.org/10.1073/pnas.95.9.5051
https://doi.org/10.1073/pnas.95.9.5051
Publikováno v:
The EMBO Journal. 16:4597-4605
Intracellular tyrosine kinases link the G protein-coupled m1 muscarinic acetylcholine receptor (mAChR) to multiple cellular responses. However, the mechanisms by which m1 mAChRs stimulate tyrosine kinase activity and the identity of the kinases withi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48cc12bdf27560efd67ee524c8abc20
https://doi.org/10.1093/emboj/16.15.4597
https://doi.org/10.1093/emboj/16.15.4597
Autor:
Ernest G. Peralta, Maya T. Kunkel
Publikováno v:
Cell. 83(3):443-449
Cardiac m2 muscarinic acetylcholine receptors reduce heart rate by coupling to heterotrimeric (alpha beta gamma) guanine nucleotide-binding (G) proteins that activate IKACh, an inward rectifier K+ channel (IRK). Activation of the GIRK subunit of IKAC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2fce2dc859a4f78f28ce7b5d5c94eb
Publikováno v:
Current Biology. 5:536-544
Background: One of the principal mechanisms by which G-protein-coupled receptors evoke cellular responses is through the activation of phospholipase C (PLC) and the subsequent release of Ca 2+ from intracellular stores. Receptors that couple to pertu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76683077aa5ae38e04a45c47f602a1b
https://doi.org/10.1016/s0960-9822(95)00106-0
https://doi.org/10.1016/s0960-9822(95)00106-0