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pro vyhledávání: '"Ernest Freeman"'
Autor:
John Shelestak, Naveen Singhal, Lana Frankle, Riely Tomor, Sarah Sternbach, Jennifer McDonough, Ernest Freeman, Robert Clements
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234001 (2020)
The cuprizone induced animal model of demyelination is characterized by demyelination in many regions of the brain with high levels of demyelination in the corpus callosum as well as changes in neuronal function by 4-6 weeks of exposure. The model is
Externí odkaz:
https://doaj.org/article/60b7279e02954cae9272d46aec89317f
Autor:
Fuzheng, Guo, Peter, Bannerman, Emily, Mills Ko, Laird, Miers, Jie, Xu, Travis, Burns, Shuo, Li, Ernest, Freeman, Jennifer A, McDonough, David, Pleasure
Publikováno v:
Annals of neurology. 77(5)
Canavan disease is caused by inactivating ASPA (aspartoacylase) mutations that prevent cleavage of N-acetyl-L-aspartate (NAA), resulting in marked elevations in central nervous system (CNS) NAA and progressively worsening leukodystrophy. We now repor