Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ernest F. Terwilliger"'
Autor:
Andrew Escayg, Tyra Lamar, Christopher D. Makinson, Jennifer C. Wong, Jeffrey C. Wingard, Qi Cheng, Ernest F. Terwilliger
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
We previously found that genetic mutants with reduced expression or activity of Scn8a are resistant to induced seizures and that co-segregation of a mutant Scn8a allele can increase survival and seizure resistance of Scn1a mutant mice. In contrast, S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232c2573a65f378bfc13f8fbfcba2dbf
https://pubmed.ncbi.nlm.nih.gov/29317669
https://pubmed.ncbi.nlm.nih.gov/29317669
Publikováno v:
Journal of Cellular and Molecular Medicine
The identification of new components implicated in the pathogenesis of osteoarthritis (OA) might improve our understanding of the disease process. Here, we investigated the levels of the survival of motor neuron (SMN) expression in OA cartilage consi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e43075aaa69383c11190090b5bb9aff2
http://europepmc.org/articles/PMC3916123
http://europepmc.org/articles/PMC3916123
Autor:
Janina Frisch, Anja Weimer, Magali Cucchiarini, Henning Madry, Jochen Jung, Gertrud Schmitt, Stephen B. Trippel, Anna Wezel, Dieter Kohn, Jagadeesh K. Venkatesan, Ernest F. Terwilliger
Publikováno v:
Molecular Medicine. 18:346-358
Administration of therapeutic genes to human osteoarthritic (OA) cartilage is a potential approach to generate effective, durable treatments against this slow, progressive disorder. Here, we tested the ability of recombinant adeno-associated virus (r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d3351b2b7ce9db65325adc2358545c
https://doi.org/10.2119/molmed.2011.00371
https://doi.org/10.2119/molmed.2011.00371
Publikováno v:
Neuroscience Letters. 502:192-196
Mesolimbic brain-derived neurotrophic factor (BDNF) is implicated in sustained behavioral changes following chronic social stress, and its depletion may reduce susceptibility to such behavioral alterations. Enhanced mesolimbic BDNF is proposed as pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a75b22879ffbe6f76b755869d7c96c
https://doi.org/10.1016/j.neulet.2011.07.043
https://doi.org/10.1016/j.neulet.2011.07.043
Autor:
Romuald Mentaverri, Michel Brazier, Alice Wattel, Edward M. Brown, Axelle Caudrillier, Ernest F. Terwilliger, Anne S. Hurtel-Lemaire, Fabienne Cournarie, Said Kamel
Publikováno v:
Journal of Biological Chemistry. 284:575-584
Strontium ranelate exerts both an anti-catabolic and an anabolic effect on bone cells. To further investigate the molecular mechanism whereby strontium ranelate inhibits bone resorption, we focused our attention on the effects of strontium ranelate o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::455610e98234333068b9582525774bed
https://doi.org/10.1074/jbc.m801668200
https://doi.org/10.1074/jbc.m801668200
Publikováno v:
Journal of Cellular and Molecular Medicine. 13:2476-2488
Compensating for the loss of extracellular cartilage matrix, as well as counteracting the alterations of the chondrocyte phenotype in osteoarthritis are of key importance to develop effective therapeutic strategies against this disorder. In the prese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18280b7399ad9e0eebabff8b2af9416e
https://doi.org/10.1111/j.1582-4934.2008.00474.x
https://doi.org/10.1111/j.1582-4934.2008.00474.x
Autor:
Jacob Tfelt-Hansen, Sanela Smajilovic, Tue E H Christoffersen, Ernest F. Terwilliger, Søren P. Sheikh, Stig Haunsø, Ewa Lewin, Edward M. Brown, Jakob Lerche Hansen
Publikováno v:
Biochemical and Biophysical Research Communications. 348:1215-1223
Extracellular calcium ( Ca 2 + o ) can act as a first messenger in many cell types through a G protein-coupled receptor, calcium-sensing receptor (CaR). It is still debated whether the CaR is expressed in vascular smooth muscle cells (VSMCs). Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae483574f74e39fea643df42e684965e
https://doi.org/10.1016/j.bbrc.2006.07.192
https://doi.org/10.1016/j.bbrc.2006.07.192
Autor:
Sanela Smajilovic, Jakob Lerche Hansen, Jacob Tfelt-Hansen, Søren P. Sheikh, Ernest F. Terwilliger, Stig Haunsø
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 290:H1165-H1171
Both intra- and extracellular calcium play multiple roles in the physiology and pathophysiology of cardiomyocytes, especially in stimulus-contraction coupling. The intracellular calcium level is closely controlled through the concerted actions of cal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c647c8a4bb817fa592be1782157e438
https://doi.org/10.1152/ajpheart.00821.2005
https://doi.org/10.1152/ajpheart.00821.2005
Publikováno v:
Virology. 341:203-214
There is strong interest in developing practical strategies for gene delivery to the central nervous system (CNS). Direct delivery into the brain or spinal cord is highly invasive as well as inefficient or hazardous using most current vector systems.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4173a44aa84aeb33bc6815173796345b
https://doi.org/10.1016/j.virol.2005.06.051
https://doi.org/10.1016/j.virol.2005.06.051
Autor:
Chunyan Ma, Ernest F. Terwilliger, Magali Cucchiarini, David Zurakowski, Stephen B. Trippel, Dieter Kohn, Tanja Thurn, Michael D. Menger, Henning Madry
Publikováno v:
Molecular Therapy. 12(2):229-238
Therapeutic gene transfer into articular cartilage is a potential means to stimulate reparative activities in tissue lesions. We previously demonstrated that direct application of recombinant adeno-associated virus (rAAV) vectors to articular chondro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae037ce30cd16b2baaa68567a89a86f