Zobrazeno 1 - 10
of 236
pro vyhledávání: '"Ernest A Gould"'
Autor:
Maxim A Khasnatinov, Andrew Tuplin, Dmitri J Gritsun, Mirko Slovak, Maria Kazimirova, Martina Lickova, Sabina Havlikova, Boris Klempa, Milan Labuda, Ernest A Gould, Tamara S Gritsun
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158105 (2016)
Over 50 million humans live in areas of potential exposure to tick-borne encephalitis virus (TBEV). The disease exhibits an estimated 16,000 cases recorded annually over 30 European and Asian countries. Conventionally, TBEV transmission to Ixodes spp
Externí odkaz:
https://doaj.org/article/a58f6037ff2a4d83907284e855bd079c
Autor:
Lauriane de Fabritus, Antoine Nougairède, Fabien Aubry, Ernest A Gould, Xavier de Lamballerie
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0159564 (2016)
Large-scale codon re-encoding is a new method of attenuating RNA viruses. However, the use of infectious clones to generate attenuated viruses has inherent technical problems. We previously developed a bacterium-free reverse genetics protocol, design
Externí odkaz:
https://doaj.org/article/11b9321b267c46e0903df53149201803
Autor:
Lauriane de Fabritus, Antoine Nougairède, Fabien Aubry, Ernest A Gould, Xavier de Lamballerie
Publikováno v:
PLoS Pathogens, Vol 11, Iss 3, p e1004738 (2015)
Large-scale codon re-encoding (i.e. introduction of a large number of synonymous mutations) is a novel method of generating attenuated viruses. Here, it was applied to the pathogenic flavivirus, tick-borne encephalitis virus (TBEV) which causes febri
Externí odkaz:
https://doaj.org/article/53918eccd20b4bb19c54b8807ad64071
Autor:
Gregory Moureau, Shelley Cook, Philippe Lemey, Antoine Nougairede, Naomi L Forrester, Maxim Khasnatinov, Remi N Charrel, Andrew E Firth, Ernest A Gould, Xavier de Lamballerie
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0117849 (2015)
To generate the most diverse phylogenetic dataset for the flaviviruses to date, we determined the genomic sequences and phylogenetic relationships of 14 flaviviruses, of which 10 are primarily associated with Culex spp. mosquitoes. We analyze these d
Externí odkaz:
https://doaj.org/article/13bf8937ffdd4cd4857ab67068c30007
Autor:
Fabien Aubry, Antoine Nougairède, Lauriane de Fabritus, Géraldine Piorkowski, Ernest A Gould, Xavier de Lamballerie
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138703 (2015)
Isolation of viral pathogens from clinical and/or animal samples has traditionally relied on either cell cultures or laboratory animal model systems. However, virus viability is notoriously susceptible to adverse conditions that may include inappropr
Externí odkaz:
https://doaj.org/article/39deea44b3504c908087c0262848cc0f
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0118963 (2015)
As a partner of the European Virus Archive (EVA) FP7 project, our laboratory maintains a large collection of freeze-dried viruses. The distribution of these viruses to academic researchers, public health organizations and industry is one major aim of
Externí odkaz:
https://doaj.org/article/25eea774cdd9419fbcf3e30b714e79ab
Autor:
Nanikaly Moyen, Laurence Thirion, Petra Emmerich, Amelia Dzia-Lepfoundzou, Hervé Richet, Yannik Boehmann, Yannick Dimi, Pierre Gallian, Ernest A Gould, Stephan Günther, Xavier de Lamballerie
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 6, p e0003833 (2015)
BACKGROUND:Ebola and Marburg viruses (family Filoviridae, genera Ebolavirus and Marburgvirus) cause haemorrhagic fevers in humans, often associated with high mortality rates. The presence of antibodies to Ebola virus (EBOV) and Marburg virus (MARV) h
Externí odkaz:
https://doaj.org/article/bc5b0ff8b3f94d88bc946c9ae2efad41
Autor:
Xiaoyan Gao, Xiaolong Li, Minghua Li, Shihong Fu, Huanyu Wang, Zhi Lu, Yuxi Cao, Ying He, Wuyang Zhu, Tingting Zhang, Ernest A Gould, Guodong Liang
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e3015 (2014)
Japanese encephalitis (JE) is arguably one of the most serious viral encephalitis diseases worldwide. China has a long history of high prevalence of Japanese encephalitis, with thousands of cases reported annually and incidence rates often exceeding
Externí odkaz:
https://doaj.org/article/b4e96950e67d4c12848fa8d1f79007af
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92056 (2014)
RNA secondary structures in the 3'untranslated regions (3'UTR) of the viruses of the family Flaviviridae, previously identified as essential (promoters) or beneficial (enhancers) for replication, have been analysed. Duplicated enhancer elements are r
Externí odkaz:
https://doaj.org/article/9ee0b387f26c446794d055ea08b37ad9
Autor:
Antoine Nougairede, Lauriane De Fabritus, Fabien Aubry, Ernest A Gould, Edward C Holmes, Xavier de Lamballerie
Publikováno v:
PLoS Pathogens, Vol 9, Iss 2, p e1003172 (2013)
Large-scale codon re-encoding represents a powerful method of attenuating viruses to generate safe and cost-effective vaccines. In contrast to specific approaches of codon re-encoding which modify genome-scale properties, we evaluated the effects of
Externí odkaz:
https://doaj.org/article/dda0d2b365ca48178662fbd1061f7891