Zobrazeno 1 - 10
of 538
pro vyhledávání: '"Ernest Hamel"'
Autor:
Elena Mariotto, Martina Canton, Chiara Marchioro, Andrea Brancale, Ernest Hamel, Katia Varani, Fabrizio Vincenzi, Tiziano De Ventura, Chiara Padroni, Giampietro Viola, Romeo Romagnoli
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7519 (2024)
Because of synergism between tubulin and HDAC inhibitors, we used the pharmacophore fusion strategy to generate potential tubulin–HDAC dual inhibitors. Drug design was based on the introduction of a N-hydroxyacrylamide or a N-hydroxypropiolamide at
Externí odkaz:
https://doaj.org/article/1e5ac161f11043a0953566f7f8829ff5
Autor:
Romeo Romagnoli, Paola Oliva, Filippo Prencipe, Stefano Manfredini, Federica Budassi, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Diana Corallo, Sanja Aveic, Lorenzo Manfreda, Elena Mariotto, Roberta Bortolozzi, Giampietro Viola
Publikováno v:
Pharmaceuticals, Vol 15, Iss 8, p 1031 (2022)
A further investigation aiming to generate new potential antitumor agents led us to synthesize a new series of twenty-two compounds characterized by the presence of the 7-(3′,4′,5′-trimethoxyphenyl)-[1,2,4]triazolo[1,5-a]pyrimidine pharmacophor
Externí odkaz:
https://doaj.org/article/cc07dc069850450cb83a094b4295b925
Autor:
Wolfgang Dohle, Andrea E. Prota, Grégory Menchon, Ernest Hamel, Michel O. Steinmetz, Barry V. L. Potter
Publikováno v:
ACS Omega, Vol 4, Iss 1, Pp 755-764 (2019)
Externí odkaz:
https://doaj.org/article/25fe86c26b2f41b2afb5b7ee20b13b6c
Autor:
Paola Oliva, Romeo Romagnoli, Barbara Cacciari, Stefano Manfredini, Chiara Padroni, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Diana Corallo, Sanja Aveic, Noemi Milan, Elena Mariotto, Giampietro Viola, Roberta Bortolozzi
Publikováno v:
Pharmaceutics, Vol 14, Iss 6, p 1191 (2022)
Two different series of fifty-two compounds, based on 3′,4′,5′-trimethoxyaniline (7a–ad) and variably substituted anilines (8a–v) at the 7-position of the 2-substituted-[1,2,4]triazolo [1,5-a]pyrimidine nucleus, had moderate to potent antip
Externí odkaz:
https://doaj.org/article/d51587f8f4754b5eb51cf08ab0edb9d3
Autor:
Farhana Islam, Arpit Doshi, Andrew J. Robles, Tasdique M. Quadery, Xin Zhang, Xilin Zhou, Ernest Hamel, Susan L. Mooberry, Aleem Gangjee
Publikováno v:
Molecules, Vol 27, Iss 1, p 321 (2022)
A series of eleven 4-substituted 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidines were designed and synthesized and their biological activities were evaluated. Synthesis involved the Gewald reaction to synthesize ethyl 2-amino-4,5,6,7-tetrahydrob
Externí odkaz:
https://doaj.org/article/7e14f2f7c8c3494e8171cf9f1f985b53
Autor:
Delia Preti, Romeo Romagnoli, Riccardo Rondanin, Barbara Cacciari, Ernest Hamel, Jan Balzarini, Sandra Liekens, Dominique Schols, Francisco Estévez-Sarmiento, José Quintana, Francisco Estévez
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1225-1238 (2018)
Inhibition of microtubule function using tubulin targeting agents has received growing attention in the last several decades. The indole scaffold has been recognized as an important scaffold in the design of novel compounds acting as antimitotic agen
Externí odkaz:
https://doaj.org/article/cb4e0939e984439cbabe4095ac2612e4
Autor:
Peter De Wulf, Rick Gussio, Paola Conti, Ernest Hamel, Leonardo Lo Presti, Andrea Pinto, Maria Rosaria Cera, Tam Luong Nguyen
PDF file, 223KB, Growth inhibition profiles of the NCI60 tumor cell lines by S-A8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::542ba844de8f46a21bc3c2bbd47dc23a
https://doi.org/10.1158/1535-7163.22498107
https://doi.org/10.1158/1535-7163.22498107
Autor:
Peter De Wulf, Rick Gussio, Paola Conti, Ernest Hamel, Leonardo Lo Presti, Andrea Pinto, Maria Rosaria Cera, Tam Luong Nguyen
PDF file, 152KB, 1H NMR spectrum of (�)-Boc-A8. The lower panel details the spectrum between 6.4 and 2.4 ppm.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a1aefd278645e6c14b10493b884634
https://doi.org/10.1158/1535-7163.22498113
https://doi.org/10.1158/1535-7163.22498113
Autor:
Peter De Wulf, Rick Gussio, Paola Conti, Ernest Hamel, Leonardo Lo Presti, Andrea Pinto, Maria Rosaria Cera, Tam Luong Nguyen
Tumor resistance to antitubulin drugs resulting from P-glycoprotein (Pgp) drug-efflux activity, increased expression of the βIII tubulin isotype, and alterations in the drug-binding sites are major obstacles in cancer therapy. Consequently, novel an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c62ecf520f5414769a98892858cdaa
https://doi.org/10.1158/1535-7163.c.6535791.v1
https://doi.org/10.1158/1535-7163.c.6535791.v1
Autor:
Peter De Wulf, Rick Gussio, Paola Conti, Ernest Hamel, Leonardo Lo Presti, Andrea Pinto, Maria Rosaria Cera, Tam Luong Nguyen
PDF file, 229KB, Growth inhibition profiles of the NCI60 tumor cell lines by R-A8.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dff70fb76e690a7021981957ae36793
https://doi.org/10.1158/1535-7163.22498110.v1
https://doi.org/10.1158/1535-7163.22498110.v1