Zobrazeno 1 - 10
of 268
pro vyhledávání: '"Ermolieff, A."'
Autor:
Zachary A. Gurard-Levin, Brian McMillan, Douglas A. Whittington, Brian Doyon, Michael D. Scholle, Jacques Ermolieff, Madhavi Bandi, Mu-Sen Liu, Alvaro Amor, William D. Mallender
Publikováno v:
SLAS Technology, Vol 29, Iss 5, Pp 100173- (2024)
Polymerase β (POLB), with dual functionality as a lyase and polymerase, plays a critical role in the base excision repair (BER) pathway to maintain genomic stability. POLB knockout and rescue studies in BRCA1/2-mutant cancer cell lines revealed that
Externí odkaz:
https://doaj.org/article/2814a1a1f9b140339aad8d4a13a4a653
Autor:
Gurard-Levin, Zachary A., McMillan, Brian, Whittington, Douglas A., Doyon, Brian, Scholle, Michael D., Ermolieff, Jacques, Bandi, Madhavi, Liu, Mu-Sen, Amor, Alvaro, Mallender, William D.
Publikováno v:
In SLAS Technology October 2024 29(5)
Akademický článek
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Autor:
Halkowycz, Petro, Grimshaw, Charles E., Keung, Walter, Tanis, Paul, Proffitt, Chris, Peacock, Kim, de Jong, Ron, Sabat, Mark, Banerjee, Urmi, Ermolieff, Jacques *
Publikováno v:
In SLAS Discovery June 2021 26(5):676-683
Autor:
Sabat, Mark, Carney, Daniel W., Hernandez-Torres, Gloria, Gibson, Tony S., Balakrishna, Deepika, Zou, Hua, Xu, Rui, Chen, Chien-Hung, de Jong, Ron, Dougan, Douglas R., Qin, Ling, Bigi-Botterill, Simone V., Chambers, Alison, Miura, Joanne, Johnson, Lucas K., Ermolieff, Jacques, Johns, Deidre, Selimkhanov, Jangir, Kwok, Lily, DeMent, Kevin
Publikováno v:
Journal of Medicinal Chemistry; 6/27/2024, Vol. 67 Issue 12, p10306-10320, 15p
Autor:
Leanne Ahronian, Xinyuan Wu, Minjie Zhang, Chengyin Min, Alice Tsai, Jacques Ermolieff, Patrick McCarren, Margaret Wyman, Ye Wang, Alborz Bejnood, Kenjie Amemiya, Brian McMillan, Nikitha Das, Brian Doyon, Andre Mignault, Colin Liang, Vassil Elitzin, Yi Yu, Samuel Meier, Ashley Choi, John Maxwell, Alan Huang
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c641c1f38c41673cca4d6cb7ca020f7
https://doi.org/10.1136/jitc-2022-sitc2022.0444
https://doi.org/10.1136/jitc-2022-sitc2022.0444
Autor:
Paul Tanis, Urmi Banerjee, Ron de Jong, Charles E. Grimshaw, Mark Sabat, Chris Proffitt, Walter Keung, Petro Halkowycz, Kim Peacock, Jacques Ermolieff
Publikováno v:
SLAS Discovery. 26:676-683
Two different signaling pathways lead to the activation of the transcription factor NF-κB, initiating distinct biological responses: The canonical NF-κB pathway activation has been implicated in host immunity and inflammatory responses, whereas the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461b487527afd747e2f0032556040ba0
https://doi.org/10.1177/2472555220964450
https://doi.org/10.1177/2472555220964450
Autor:
Paul Rolzin, Jennifer Matuszkiewicz, James Bilakovics, Alok Pachori, Christopher J. Zopf, Pamela Farrell, Huey-Jing Huang, Artur Plonowski, Urmi Banerjee, Andrea Fanjul, Christopher McBride, Christopher J. Larson, Corine Holub, Zacharia Cheruvallath, Jacques Ermolieff, Darian Bartkowski, Crystal Mazur, Deepika Balakrishna
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 371:299-308
Target-engagement pharmacodynamic (PD) biomarkers are valuable tools in the prioritization of drug candidates, especially for novel, first-in-class mechanisms whose robustness to alter disease outcome is unknown. Methionine aminopeptidase 2 (MetAP2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190c881ee391f64b555b89dd5b10a54a
https://doi.org/10.1124/jpet.119.259028
https://doi.org/10.1124/jpet.119.259028
Autor:
Bigi-Botterill, Simone V., Ivetac, Anthony, Bradshaw, Erica L., Cole, Derek, Dougan, Douglas R., Ermolieff, Jacques, Halkowycz, Petro, Johnson, Ben, McBride, Christopher, Pickens, Jason, Sabat, Mark, Swann, Steven
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 September 2020 30(17)
Autor:
Simone V, Bigi-Botterill, Anthony, Ivetac, Erica L, Bradshaw, Derek, Cole, Douglas R, Dougan, Jacques, Ermolieff, Petro, Halkowycz, Ben, Johnson, Christopher, McBride, Jason, Pickens, Mark, Sabat, Steven, Swann
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(17)
Apoptosis Signal-Regulating Kinase-1 (ASK1) is a known member of the Mitogen-Activated Protein Kinase Kinase Kinase (MAP3K) family and upon stimulation will activate the p38- and JNK-pathways leading to cardiac apoptosis, fibrosis, and hypertrophy. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e9508fc04218099085008152ac9ef4b6
https://pubmed.ncbi.nlm.nih.gov/32738982
https://pubmed.ncbi.nlm.nih.gov/32738982